| February (11–3)  |    | Date  |  Time (ET)  |  Opponent  |  Rank  |  Site/Stadium  |  Score  |  Win  |  Loss  |  Save  |  Attendance  |  Overall Record  |  ACC Record  |    | Feb 8 |  7:00 p.m. |  vs. Missouri State* |  No. 5 |  Eddie C. Moore Complex • Clearwater, FL (NFCA Leadoff Classic) |  W 12–0 (5) |  McCubbin (1–0) |  Johnston (0–1) |  None |  N/A |  1–0 |  –  |    | Feb 9 |  7:00 p.m. |  vs. Indiana* |  No. 5 |  Eddie C. Moore Complex • Clearwater, FL (NFCA Leadoff Classic) |  W 3–2 |  Thompson (1–0) |  Copeland (1–1) |  Cagle (1) |  323 |  2–0 |  –  |    | Feb 10 |  4:00 p.m. |  vs. Liberty* |  No. 5 |  Eddie C. Moore Complex • Clearwater, FL (NFCA Leadoff Classic) |  W 7–3 |  McCubbin (2–0) |  Love (0–1) |  None |  453 |  3–0 |  –  |    | Feb 10 |  7:00 p.m. |  vs. No. 15 Oregon* |  No. 5 |  Eddie C. Moore Complex • Clearwater, FL (NFCA Leadoff Classic) |  W 3–2 |  Cagle (1–0) |  Scott (1–1) |  None |  622 |  4–0 |  –  |    | Feb 11 |  1:00 a.m. |  vs. Missouri* |  No. 5 |  Eddie C. Moore Complex • Clearwater, FL (NFCA Leadoff Classic) |  L 1–4 |  Krings (3–0) |  McCubbin (2–1) |  None |  573 |  4–1 |  –  |    | Feb 14 |  12:00 p.m. |  vs. Wichita State* |  No. 8 |  Nancy Almaraz Field • Puerto Vallarta, Mexico (Puerto Vallarta College Challenge) |  W 7–0 |  Cagle (2–0) |  Cooper (0–1) |  None |  231 |  5–1 |  –  |    | Feb 14 |  2:30 p.m. |  vs. UC San Diego* |  No. 8 |  Nancy Almaraz Field • Puerto Vallarta, Mexico (Puerto Vallarta College Challenge) |  W 6–4 |  McCubbin (3–1) |  Williams (0–1) |  Cagle (2) |  187 |  6–1 |  –  |    | Feb 16 |  7:00 p.m. |  vs. Utah* |  No. 8 |  Nancy Almaraz Field • Puerto Vallarta, Mexico (Puerto Vallarta College Challenge) |  Cancelled  |    | Feb 17 |  4:00 p.m. |  vs. No. 25 Auburn* |  No. 8 |  Nancy Almaraz Field • Puerto Vallarta, Mexico (Puerto Vallarta College Challenge) |  Cancelled  |    | Feb 17 |  9:30 p.m. |  vs. Mississippi State* |  No. 8 |  Nancy Almaraz Field • Puerto Vallarta, Mexico (Puerto Vallarta College Challenge) |  L 3–6 |  Wesley (3–0) |  Cagle (2–1) |  None |  312 |  6–2 |  –  |    | Feb 21 |  6:00 p.m. |  at Charlotte* |  No. 9 |  Sue M. Daughtridge Stadium • Charlotte, NC |  W 8–5 |  McCubbin (4–1) |  Elkins (2–2) |  None |  950 |  7–2 |  –  |    | Feb 23 |  4:00 p.m. |  Ole Miss* |  No. 9 |  McWhorter Stadium • Clemson, SC (Clemson Classic) |  W 9–1 (6) |  Cagle (3–1) |  Kliethermes (4–1) |  None |  2,049 |  8–2 |  –  |    | Feb 24 |  1:30 p.m. |  Miami (OH)* |  No. 9 |  McWhorter Stadium • Clemson, SC (Clemson Classic) |  W 10–1 (5) |  McCubbin (5–1) |  Hitchcock (2–1) |  None |  1,522 |  9–2 |  –  |    | Feb 24 |  4:00 p.m. |  Connecticut* |  No. 9 |  McWhorter Stadium • Clemson, SC (Clemson Classic) |  W 3–2 (8) |  Cagle (4–1) |  O'Neil (1–3) |  None |  2,116 |  10–2 |  –  |    | Feb 25 |  12:30 p.m. |  Ole Miss* |  No. 9 |  McWhorter Stadium • Clemson, SC (Clemson Classic) |  W 5–0 |  Cagle (5–1) |  Furbush (1–1) |  None |  1,766 |  11–2 |  –  |    | Feb 28 |  5:00 p.m. |  at No. 5 Georgia* |  No. 8 |  Jack Turner Stadium • Athens, GA |  L 1–2 (8) |  Backes (4–0) |  Cagle (5–2) |  None |  864 |  11–3 |  –  |      | March (13–7)  |    | Date  |  Time (ET)  |  Opponent  |  Rank  |  Site/Stadium  |  Score  |  Win  |  Loss  |  Save  |  Attendance  |  Overall Record  |  ACC Record  |    | Mar 2 |  1:00 p.m. |  NC State |  No. 8 |  McWhorter Stadium • Clemson, SC |  L 1–6 |  Weixlmann (6–1) |  McCubbin (5–2) |  None |  1,868 |  11–4 |  0–1  |    | Mar 2 |  3:00 p.m. |  NC State |  No. 8 |  McWhorter Stadium • Clemson, SC |  W 8–0 (5) |  Cagle (6–2) |  Wyman (3–2) |  None |  1,973 |  12–4 |  1–1  |    | Mar 3 |  12:00 p.m. |  NC State |  No. 8 |  McWhorter Stadium • Clemson, SC |  W 14–9 |  Spencer (1–0) |  Inscoe (3–2) |  McCubbin (1) |  1,832 |  13–4 |  2–1  |    | Mar 5 |  6:00 p.m. |  No. 8 Tennessee* |  No. 10 |  McWhorter Stadium • Clemson, SC |  L 1–2 (9) |  Pickens (8–2) |  Cagle (6–3) |  None |  1,883 |  13–5 |  –  |    | Mar 7 |  4:00 p.m. |  Minnesota* |  No. 10 |  McWhorter Stadium • Clemson, SC (Tiger Invitational) |  L 3–5 (9) |  Enter (6–3) |  Cagle (6–4) |  None |  1,678 |  13–6 |  –  |    | Mar 7 |  6:00 p.m. |  Minnesota* |  No. 10 |  McWhorter Stadium • Clemson, SC (Tiger Invitational) |  W 3–1 |  Spencer (2–0) |  Richardson (0–1) |  None |  1,698 |  14–6 |  –  |    | Mar 8 |  6:00 p.m. |  Mercer* |  No. 10 |  McWhorter Stadium • Clemson, SC (Tiger Invitational) |  W 7–2 |  Thompson (2–0) |  Pitts (1–3) |  None |  1,761 |  15–6 |  –  |    | Mar 9 |  6:00 p.m. |  Longwood* |  No. 10 |  McWhorter Stadium • Clemson, SC (Tiger Invitational) |  W 9–1 (6) |  Cagle (7–4) |  Chapin (7–6) |  None |  1,912 |  16–6 |  –  |    | Mar 10 |  12:30 p.m. |  Fordham* |  No. 10 |  McWhorter Stadium • Clemson, SC (Tiger Invitational) |  W 12–0 |  Spencer (3–0) |  Simcoe (0–4) |  None |  1,842 |  17–6 |  –  |    | Mar 13 |  6:00 p.m. |  Gardner–Webb* |  No. 12 |  McWhorter Stadium • Clemson, SC |  W 8–0 (5) |  Thompson (3–0) |  Lyon (8–3) |  None |  1,702 |  18–6 |  –  |    | Mar 15 |  6:00 p.m. |  North Carolina |  No. 12 |  McWhorter Stadium • Clemson, SC |  W 5–0 |  Spencer (4–0) |  Harris (5–3) |  None |  1,826 |  19–6 |  3–1  |    | Mar 16 |  1:00 p.m. |  North Carolina |  No. 12 |  McWhorter Stadium • Clemson, SC |  W 4–1 |  Thompson (4–0) |  Dark (4–1) |  None |  1,916 |  20–6 |  4–1  |    | Mar 17 |  7:00 p.m. |  North Carolina |  No. 12 |  McWhorter Stadium • Clemson, SC |  W 9–1 (5) |  McCubbin (6–2) |  Rogers (8–1) |  None |  1,769 |  21–6 |  5–1  |    | Mar 20 |  6:00 p.m. |  No. 23 South Carolina* |  No. 11 |  McWhorter Stadium • Clemson, SC (Rivalry) |  L 4–6 (12) |  Vawter (8–4) |  Thompson (4–1) |  None |  1,867 |  21–7 |  –  |    | Mar 22 |  5:00 p.m. |  at Virginia |  No. 11 |  Palmer Park • Charlottesville, VA |  L 4–6 |  Marris (5–1) |  Cagle (7–5) |  Eigham (2) |  702 |  21–8 |  5–2  |    | Mar 23 |  1:00 p.m. |  at Virginia |  No. 11 |  Palmer Park • Charlottesville, VA |  W 5–1 |  Spencer (5–0) |  Bigham (7–6) |  None |  1,122 |  22–8 |  6–2  |    | Mar 24 |  12:00 p.m. |  at Virginia |  No. 11 |  Palmer Park • Charlottesville, VA |  L 0–3 |  Harris (6–1) |  Thompson (4–2) |  None |  1,019 |  22–9 |  6–3  |    | Mar 26 |  5:00 p.m. |  Georgia State* |  No. 16 |  McWhorter Stadium • Clemson, SC |  Cancelled[3]  |    | Mar 28 |  6:00 p.m. |  Boston College |  No. 16 |  McWhorter Stadium • Clemson, SC |  W 10–2 (5) |  Spencer (6–0) |  Dunning (9–6) |  None |  1,764 |  23–9 |  7–3  |    | Mar 29 |  1:00 p.m. |  Boston College |  No. 16 |  McWhorter Stadium • Clemson, SC |  L 0–4 |  Dunning (10–6) |  Thompson (4–3) |  None |  1,914 |  23–10 |  7–4  |    | Mar 30 |  12:00 p.m. |  Boston College |  No. 16 |  McWhorter Stadium • Clemson, SC |  W 10–0 (5) |  McCubbin (7–2) |  Pappion (7–4) |  Spencer (1) |  2,116 |  24–10 |  8–4  |      | April (9–6)  |    | Date  |  Time (ET)  |  Opponent  |  Rank  |  Site/Stadium  |  Score  |  Win  |  Loss  |  Save  |  Attendance  |  Overall Record  |  ACC Record  |    | Apr 2 |  6:00 p.m. |  Furman* |  No. 17 |  McWhorter Stadium • Clemson, SC |  L 3–4 |  L. Scott (7–2) |  Thompson (4–4) |  None |  1,819 |  24–11 |  –  |    | Apr 6 |  4:00 p.m. |  at Syracuse |  No. 17 |  Softball Stadium at Skytop • Syracuse, NY |  W 13–2 (5) |  Spencer (7–0) |  Hendrix (7–3) |  None |  153 |  25–11 |  9–4  |    | Apr 7 |  10:00 a.m. |  at Syracuse |  No. 17 |  Softball Stadium at Skytop • Syracuse, NY |  W 10–1 (6) |  Thompson (5–4) |  Lewinski (2–6) |  None |  174 |  26–11 |  10–4  |    | Apr 7 |  12:00 p.m. |  at Syracuse |  No. 17 |  Softball Stadium at Skytop • Syracuse, NY |  W 7–1 |  McCubbin (8–2) |  Knight (3–5) |  None |  27–11 |  11–4  |    | Apr 9 |  6:00 p.m. |  at No. 23 South Carolina* |  No. 19 |  Beckham Field • Columbia, SC (Rivalry) |  W 7–0 |  Spencer (8–0) |  Mardjetko (6–6) |  Thompson (1) |  2,055 |  28–11 |  –  |    | Apr 12 |  6:00 p.m. |  No. 3 Duke |  No. 19 |  McWhorter Stadium • Clemson, SC |  L 9–13 |  Walker (10–1) |  Spencer (8–1) |  None |  1,915 |  28–12 |  11–5  |    | Apr 13 |  1:00 p.m. |  No. 3 Duke |  No. 19 |  McWhorter Stadium • Clemson, SC |  L 3–4 |  Wright (13–1) |  Thompson (5–5) |  Walker (3) |  2,116 |  28–13 |  11–6  |    | Apr 14 |  12:00 p.m. |  No. 3 Duke |  No. 19 |  McWhorter Stadium • Clemson, SC |  L 1–6 |  Curd (8–2) |  Spencer (8–2) |  Wright (1) |  1,940 |  28–14 |  11–7  |    | Apr 16 |  6:00 p.m. |  Winthrop* |  No. 21 |  McWhorter Stadium • Clemson, SC |  W 4–0 |  McCubbin (9–2) |  Basinger (9–13) |  None |  1,592 |  29–14 |  –  |    | Apr 19 |  5:00 p.m. |  at Notre Dame |  No. 21 |  Melissa Cook Stadium • Notre Dame, IN |  W 8–5 (10) |  McCubbin (10–2) |  Kastor (8–8) |  None |  438 |  30–14 |  12–7  |    | Apr 20 |  1:00 p.m. |  at Notre Dame |  No. 21 |  Melissa Cook Stadium • Notre Dame, IN |  W 11–6 |  Cagle 8–5 |  Laudenslager (9–7) |  None |  534 |  31–14 |  13–7  |    | Apr 21 |  6:00 p.m. |  at Notre Dame |  No. 21 |  Melissa Cook Stadium • Notre Dame, IN |  L 5–6 |  Becker (7–5) |  Spencer (8–3) |  None |  312 |  31–15 |  13–8  |    | Apr 26 |  6:00 p.m. |  at Louisville |  No. 22 |  Ulmer Stadium • Louisville, KY |  W 6–5 |  Thompson (6–5) |  Zabala (18–13) |  None |  356 |  32–15 |  14–8  |    | Apr 27 |  1:00 p.m. |  at Louisville |  No. 22 |  Ulmer Stadium • Louisville, KY |  L 3–6 |  Booe (3–3) |  Cagle 8–6 |  None |  389 |  32–16 |  14–9  |    | Apr 28 |  12:00 p.m. |  at Louisville |  No. 22 |  Ulmer Stadium • Louisville, KY |  W 11–5 |  Spencer (9–3) |  Zabala (18–14) |  None |  446 |  33–16 |  15–9  |     |