Butidrine

Butidrine
Clinical data
Trade names	Betabloc, Butidrate, Recetan
Other names	Butedrine; Butydrine; Hydrobutamine; Idrobutamine
Drug class	Beta blocker
Identifiers
	IUPAC name 2-(butan-2-ylamino)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanol;
CAS Number	7433-10-5 ;
PubChem CID	15177;
ChemSpider	14445;
UNII	N2S0PKP5L5;
ChEBI	CHEBI:135008;
ChEMBL	ChEMBL358930;
CompTox Dashboard (EPA)	DTXSID40864062 ;
Chemical and physical data
Formula	C16H25NO
Molar mass	247.382 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(C)NCC(C1=CC2=C(CCCC2)C=C1)O;
	InChI InChI=1S/C16H25NO/c1-3-12(2)17-11-16(18)15-9-8-13-6-4-5-7-14(13)10-15/h8-10,12,16-18H,3-7,11H2,1-2H3; Key:GVNYSERWAKVROD-UHFFFAOYSA-N;

Butidrine (INNTooltip International Nonproprietary Name), sold under the brand names Betabloc, Butidrate, and Recetan among others, is a beta blocker (or β-adrenergic receptor antagonist) related to pronethalol^[1] and propranolol^[2] that was developed in the 1960s.^[3]^[4] It is not cardioselective (i.e., is not selective for the β₁-adrenergic receptor over the β₂-adrenergic receptor).^[5] It has membrane stabilizing activity but no intrinsic sympathomimetic activity (i.e., partial agonist activity).^[6] Similarly to certain other beta blockers, butidrine additionally possesses local anesthetic properties.^[7]

References

^ Bristol JA (1986). Cardiovascular drugs. John Wiley & Sons, Incorporated. p. 111. ISBN 978-0-471-09228-5.
^ Drug Metabolism Reviews. Marcel Dekker. 1972.
^ Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 58–. ISBN 978-94-011-4439-1.
^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 197–. ISBN 978-1-4757-2085-3.
^ Sokabe, Hirofumi (1985). "A new classification of β-adrenoceptor blocking drugs". Trends in Pharmacological Sciences. 6: 107–109. doi:10.1016/0165-6147(85)90051-3.
^ Fitzgerald JD (1969). "Perspectives in adrenergic beta-receptor blockade". Clin Pharmacol Ther. 10 (3): 292–306. doi:10.1002/cpt1969103292. PMID 4894830.
^ Charlier R (1971). Antianginal drugs: pathophysiological, haemodynamic, methodological, pharmacological, biochemical and clinical basis for their use in human therapeutics. Springer-Verlag. ISBN 978-3-540-05365-1.