Grape Island
Grape Island may refer to
- Grape Island (West Virginia), in the Ohio River
 - Grape Island, West Virginia, an unincorporated community in Pleasants County, West Virginia
 - Grape Island (Lake Michigan), part of the Beaver Island (Lake Michigan) archipelago
 - Grape Island (Massachusetts), one of the Boston Harbor Islands
 - Grape Island (Essex County, Massachusetts), Plum Island Sound, Ipswich, Massachusetts
 - Grape Island (Lake Simcoe), Ontario, Canada