José Acosta
José Acosta may refer to:
- José Acosta (baseball) (1891–1977), Cuban baseball player
 - José Acosta Cubero (born 1947), Spanish politician
 - José de Acosta (1540–1600), Jesuit naturalist and missionary in Latin America
 - José Eugenio Acosta (1942–2006), Argentine equestrian
 - José Julián Acosta (1825–1891), journalist and advocate of the abolition of slavery in Puerto Rico