| Title | Publisher | Game type | Year(s) published | Unit name |
| Starship Troopers | Avalon Hill | Board wargame | 1976 | Mobile Infantry |
| Traveller | Game Designers' Workshop | Role-playing game | 1977 | Star Marines, Terran Confederation Marine Corps, Imperial Marine Force, Solomani Marine Corps, and Zhodani Consular Guard |
| Space Marines | Fantac/Fantasy Games Unlimited | Wargaming; Tabletop game; Dice game | 1977/1980 | Terran UnionGuard Heavy Infantry, Azuriach Heavy Infantry |
| Starfire series | Task Force Games; Starfire Design Studio | Board wargame | 1979–present | Federation Navy Marine Corps |
| Space Marines | Asgard Miniatures | Science Fiction Miniature Line | 1982–present | Space Marine/Space Trooper. The miniatures in this line were created for use with Laserburn and are currently available through Alternative Armies |
| Star Frontiers | TSR, Inc. | Role-playing game | 1982–1985 | Space Marine. The career name for NPCs with a focus in beam weapons. |
| Metroid series | Nintendo | Action-adventure game | 1986–present | Galactic Federation Marine Corps/07th Platoon |
| Princess Ryan's Space Marines | Simulations Tacticals (SIMTAC) | 1/285 Scale Tabletop Miniatures Game | 1986 | Princess Ryan's Space Marines |
| Warhammer 40,000 series | Games Workshop | Miniature wargaming; Tabletop game; Dice game | 1987–present | Adeptus Astartes (Imperial Space Marine) Chapters, and also, to an extent, Chaos Space Marines. |
| Wing Commander franchise | Origin Systems, Inc. | Space combat simulation | 1990–1999 | Terran Confederation Marine Corps |
| Duke Nukem series | 3D Realms | First-person shooter; Platform | 1991–present | Earth Defense Forces (EDF) |
| Doom series | id software | First-person shooter | 1993–present | |
| Marathon series | Bungie | First-person shooter | 1994–present | UESC (Unified Earth Space Council) Marines |
| Quake series | id software | First-person shooter | 1996–present | SMC (Space Marine Corps) Marines, GDF (Global Defence Force) |
| Unreal series | Epic Games | First-person shooter | 1998–present | UMS (Unified Military Services) |
| Outwars | Microsoft | Third-person shooter; Tactical shooter | 1998 | Colonial Marines |
| Battlezone | Activision | first-person shooter; real-time strategy | 1998 | National Space Defense Force (NSDF), Cosmos Colonist Army/Communist Cosmonaut Army (CCA), Chinese Red Army (CRA), International Space Defence Force (ISDF) |
| StarCraft series | Blizzard Entertainment | Real-time strategy | 1998–present | Confederate Marine Corps, the Dominion Marine Corps, the Alliance Marine Corps, the Alpha Corps, the United Earth Directorate Powered Infantry and numerous more |
| Ground Control | Sierra On-Line | Real-time tactics | 2000 | Crayven Corporation's Marines |
| Halo series | Xbox Game Studios | First-person shooter; Real-time strategy | 2001–present | United Nations Space Command Marine Corps and the elite Orbital Drop Shock Trooper divisions (special forces qualified for drop pod insertion). |
| Red Faction series | THQ | First-person shooter; Third-person shooter | 2001–present | Earth Defence Marine Corps (E.D.M.C.) and Earth Naval Guard (E.N.G.) |
| Natural Selection | Unknown Worlds Entertainment | First-person shooter; Real-time strategy | 2002–2007 | Frontiersmen (human space marines) |
| TimeSplitters 2 | Eidos Interactive | First-person shooter | 2002 | Space Marines (Sergeant Cortez and Corporal Hart) |
| Killzone series | SCEE | First-person shooter | 2003–present | Interplanetary Strategic Alliance Marines |
| TimeSplitters: Future Perfect | Electronic Arts | First-person shooter | 2005 | Space Marines (Sergeant Cortez) (This got changed during scripting as it was pointed out that Space Marine might infringe on Games Workshop name.) |
| Mass Effect series | Microsoft Game Studios; Electronic Arts | Action role-playing game; Third-person shooter | 2007–present | designated personnel of the Systems Alliance Navy (no branch independence) |
| Dead Space series | Electronic Arts | Survival horror; Third-person shooter | 2008–present | USM Marine Corps (a branch of the Earth Defense Force) |
| Turok | Touchstone Interactive | Action game; First-person shooter | 2008 | Marines (also referred to as Commandos) |
| Eat Lead: The Return of Matt Hazard | D3 Publisher | Action game; Third-person shooter | 2009 | Space Marines |
| Fallout 3: Mothership Zeta | Bethesda | Role playing game; First-person shooter | 2009 | American army medic Eliot Tecorian and the two surviving members of his squad are abducted by aliens, and assist the Vault Dweller in hijacking the spaceship. The player can also equip themself with pre-war power armor similar in appearance to the Marauder armor worn by the Mobile Infantry. |
| Alien Swarm | Valve | Action game; Third-person shooter; Shoot-em-up; Top-down | 2010 | Space Marines – the game can be single player or 4 players co-op. There are 4 classes with 2 characters for each class: Officer, Special Weapons, Medic and Tech. |
| Warhammer 40,000 Armageddon | Slitherine | Turn-based strategy | 2014 | Space Marines |
| Wolfenstein: The New Order | Bethesda | Action-adventure, first-person shooter | 2014 | Weltraumsoldaten, Weltraummarinesoldaten |
| Helldivers | Arrowhead Game Studios | First-person shooter, Shoot'em up | 2015–present | Helldivers, Super Earth Defense Force |
| Bombshell | 3D Realms | multidirectional shooter | 2016 | Global Defence Force (GDF) |
| The Outer Worlds | Obsidian Entertainment | First-person shooter, Role-playing video game | 2019 | Mardets, short for Marine Detachment. |