| Date | Co-hosts | "Host Chat"[1] | Guests/segments[2] |
| March 1 | Regis Philbin & Kelly Ripa | | LIVE! in Los Angeles, Melina Kanakaredes, Jimmy Kimmel, Brian McKnight |
| March 2 | Regis Philbin & Kelly Ripa | | LIVE! in Los Angeles, Anthony LaPaglia, Bo Bice, Sasha Cohen, a visit to the set of CSI: Crime Scene Investigation |
| March 3 | Regis Philbin & Kelly Ripa | | LIVE! in Los Angeles, Raven-Symoné, William H. Macy, Behind the Scenes with Kobe Bryant and other Los Angeles Lakers |
| March 6 | Regis Philbin & Kelly Ripa | | Bill Paxton, an Oscar recap by Claudia Cohen |
| March 7 | Regis Philbin & Kelly Ripa | | Jo Frost, Dennis Haysbert, Ne-Yo |
| March 8 | Regis Philbin & Kelly Ripa | | Matthew McConaughey, Gretchen Wilson |
| March 9 | Regis Philbin & Kelly Ripa | | Salma Hayek, Bradley Cooper |
| March 10 | Regis Philbin & Kelly Ripa | | Kristin Davis, Idina Menzel |
| March 13 | Regis Philbin & Kelly Ripa | | Julia Louis-Dreyfus, Ashley Parker Angel |
| March 14 | Regis Philbin & Kelly Ripa | | Pat Sajak, Carrie Underwood |
| March 15 | Regis Philbin & Kelly Ripa | | Ice-T |
| March 16 | Regis Philbin & Kelly Ripa | | Vin Diesel, Ludacris, A report from the American International Toy Fair |
| March 17 | Regis Philbin & Kelly Ripa | | Celtic Woman |
| March 20 | Regis Philbin & Joy Philbin | | Wentworth Miller, Clive Owen, Chris Brown |
| March 21 | Regis Philbin & Joy Philbin | | Michael Chiklis, Denzel Washington |
| March 22 | Regis Philbin & Joy Philbin | | Dominic Chianese, Kurt Busch |
| March 23 | Regis Philbin & Lisa Rinna | | Frankie Muniz, Cascada |
| March 24 | Regis Philbin & Wendie Malick | | Jamie-Lynn Sigler, animal expert Peter Gros, a segment on Consumer Reports' Oyster Awards for packaging that is difficult to open |
| March 27 | Regis Philbin & Kelly Ripa | | Shakira & Wyclef Jean, Chris Kattan, Larry the Cable Guy |
| March 28 | Regis Philbin & Kelly Ripa | | Ray Romano, psychic Char Margolis |
| March 29 | Regis Philbin & Kelly Ripa | | Queen Latifah, Richard Ashcroft |
| March 30 | Regis Philbin & Kelly Ripa | | Josh Hartnett, Tori Spelling, the winner of the National Spelling Bee |