South Middleton
South Middleton can refer to:
- South Middleton, Greater Manchester, a ward of Rochdale Borough Council, England
 - South Middleton, Ilderton, a location in Northumberland, England
 - South Middleton, Wallington Demesne, a former civil parish, now in Wallington Demesne, Northumberland, England
 - South Middleton, Ontario, Canada
 - South Middleton Township, Pennsylvania, USA