Tocofersolan

Tocofersolan
Clinical data
Trade names	Vedrop
Other names	Tocophersolan (USAN US)
AHFS/Drugs.com	UK Drug Information
Legal status
Legal status	UK: POM (Prescription only); EU: Rx-only;
Identifiers
DrugBank	DB11635;
KEGG	D06174;
CompTox Dashboard (EPA)	DTXSID90872278 DTXSID1048623, DTXSID90872278 ;
ECHA InfoCard	100.123.651

Tocofersolan
Names
	IUPAC name α-Hydro-ω-{[4-oxo-4-({(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl}oxy)butanoyl]oxy}poly(oxyethylene)
	Other names Tocofersolan; Vitamin E PEG succinate; α-Tocopherol polyethylene glycol succinate (TPGS); Liqui-E
Identifiers
CAS Number	9002-96-4 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL2355578;
ChemSpider	64498 ;
DrugBank	DB11635;
ECHA InfoCard	100.123.651
EC Number	618-345-6;
PubChem CID	9938056;
UNII	O03S90U1F2 ;
CompTox Dashboard (EPA)	DTXSID90872278 DTXSID1048623, DTXSID90872278 ;
	InChI InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3 Key: AOBORMOPSGHCAX-UHFFFAOYSA-N ; InChI=1/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3 Key: AOBORMOPSGHCAX-UHFFFAOYAU;
	SMILES O=C(OCCO)CCC(=O)Oc2c(c(c1OC(CCc1c2C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)C;
Properties
Chemical formula	(C2H4O)nC33H54O5
Molar mass	Variable
Pharmacology
ATC code	A11HA08 (WHO)
License data	EU EMA: by INN;
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Tocofersolan (INN; also known as tocophersolan, tocopherol polyethylene glycol succinate, or TPGS) is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is a polyethylene glycol (PEG) derivative of α-tocopherol succinate. The addition of PEG enables water solubility.

Tocofersolan is used as a vitamin E supplement or to treat vitamin E deficiency in individuals who cannot absorb fats due to disease.^[3] On 24 July 2009 the European Medicines Agency approved tocofersolan under the trade name Vedrop 50 mg/ml oral solution for the treatment of vitamin E deficiency due to digestive malabsorption in paediatric patients with congenital or hereditary chronic cholestasis, from birth (in term newborns) to 16 or 18 years of age (depending on the region).^[4]

Tocofersolan is also used in cosmetics and pharmaceuticals as an antioxidant.^[5]

References

^ "Vedrop 50 mg/ml oral solution - Summary of Product Characteristics (SmPC)". (emc). 19 June 2019. Retrieved 24 July 2020.
^ "Vedrop EPAR". European Medicines Agency (EMA). Archived from the original on 24 July 2020. Retrieved 24 July 2020.
^ "Tocophersolan Oral". WebMD.
^ "Vedrop Summary of Product Characteristics" (PDF). European Medicines Agency.
^ Ash M, Ash I (2004). Handbook of Preservatives. Synapse Info Resources. p. 568. ISBN 1-890595-66-7.

[1] "Vedrop 50 mg/ml oral solution - Summary of Product Characteristics (SmPC)". (emc). 19 June 2019. Retrieved 24 July 2020.

[2] "Vedrop EPAR". European Medicines Agency (EMA). Archived from the original on 24 July 2020. Retrieved 24 July 2020.

[3] "Tocophersolan Oral". WebMD.

[4] "Vedrop Summary of Product Characteristics" (PDF). European Medicines Agency.

[5] Ash M, Ash I (2004). Handbook of Preservatives. Synapse Info Resources. p. 568. ISBN 1-890595-66-7.

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