Euphorbia poissonii,[1] also known as Euphorbia poissoni [2] and, incorrectly, as Euphorbia poisoni, is a highly irritant and toxic succulent member of the large and varied spurge family of plants.[3]  It is native to northern Nigeria, where local farmers extract its latex for use as a pesticide. Its powerfully irritant and pain-producing nature mandates use as a fencing plant. It is known to the Berom people of the Jos area as pyùlúp who transplant it to their compounds where it is regarded as protection against witchcraft. 
It is named for French botanist Henri Louis Poisson, who formally described other Euphorbia species. 
 Toxic activity
 In addition to a variety of irritant phorbol-type esters, the latex contains resiniferatoxin and tinyatoxin, two closely related highly irritant resiniferonol-type esters.[3] The most active toxin, resiniferatoxin, binds to pain receptors in the same way as capsaicin but much more powerfully.  It stimulates the neurons to fire repeatedly, causing pain. 
Due to its selective nature of binding and killing pain receptors while leaving other nerve cells intact, resiniferatoxin is currently being researched as a possible treatment for chronic pain. 
 References
  External links
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| TRPA | | Activators |  4-Hydroxynonenal4-Oxo-2-nonenal5,6-EET12S-HpETE15-Deoxy-Δ12,14-prostaglandin J2α-Sanshool (ginger, Sichuan and melegueta peppers)AcroleinAllicin (garlic)Allyl isothiocyanate (mustard, radish, horseradish, wasabi)AM404ASP-7663BradykininCannabichromene (cannabis)Cannabidiol (cannabis)Cannabigerol (cannabis)Cinnamaldehyde (cinnamon)CR gas (dibenzoxazepine; DBO)CS gas (2-chlorobenzal malononitrile)Cuminaldehyde (cumin)Curcumin (turmeric)Dehydroligustilide (celery)Diallyl disulfideDicentrine (Lindera spp.)Farnesyl thiosalicylic acidFormalinGingerols (ginger)Hepoxilin A3Hepoxilin B3Hydrogen peroxideIcilinIsothiocyanateJT-010Ligustilide (celery, Angelica acutiloba)Linalool (Sichuan pepper, thyme)MethylglyoxalMethyl salicylate (wintergreen)N-MethylmaleimideNicotine (tobacco)Oleocanthal (olive oil)Paclitaxel (Pacific yew)Paracetamol (acetaminophen)PF-4840154Phenacyl chloridePolygodial (Dorrigo pepper)Shogaols (ginger, Sichuan and melegueta peppers)Tear gasesTetrahydrocannabinol (cannabis)TetrahydrocannabiorcolThiopropanal S-oxide (onion)Umbellulone (Umbellularia californica)WIN 55,212-2
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| TRPV | | Activators |  2-APB5,6-EET9-HODE9-oxoODE12S-HETE12S-HpETE13-HODE13-oxoODE20-HETEα-Sanshool (ginger, Sichuan and melegueta peppers)Allicin (garlic)AM404AnandamideBisandrographolide (Andrographis paniculata)Camphor (camphor laurel, rosemary, camphorweed, African blue basil, camphor basil)Cannabidiol (cannabis)Cannabidivarin (cannabis)Capsaicin (chili pepper)Carvacrol (oregano, thyme, pepperwort, wild bergamot, others)DHEADiacyl glycerolDihydrocapsaicin (chili pepper)EstradiolEugenol (basil, clove)Evodiamine (Euodia ruticarpa)Gingerols (ginger)GSK1016790AHeatHepoxilin A3Hepoxilin B3Homocapsaicin (chili pepper)Homodihydrocapsaicin (chili pepper)Incensole (incense)Lysophosphatidic acidLow pH (acidic conditions)Menthol (mint)N-Arachidonoyl dopamineN-OleoyldopamineN-OleoylethanolamideNonivamide (PAVA) (PAVA spray)Nordihydrocapsaicin (chili pepper)Paclitaxel (Pacific yew)Paracetamol (acetaminophen)PhenylacetylrinvanilPhorbol esters (e.g., 4α-PDD)Piperine (black pepper, long pepper)Polygodial (Dorrigo pepper)ProbenecidProtonsRhTxRutamarin (Ruta graveolens)Resiniferatoxin (RTX) (Euphorbia resinifera/)Shogaols (ginger, Sichuan and melegueta peppers)Tetrahydrocannabivarin (cannabis)Thymol (thyme, oregano)Tinyatoxin (Euphorbia resinifera/)TramadolVanillin (vanilla)Zucapsaicin
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| See also: Receptor/signaling modulators • Ion channel modulators | 
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| Euphorbia poissonii |  | 
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