Glyceronephosphate O-acyltransferase

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Structures	Swiss-model
Domains	InterPro

glyceronephosphate O-acyltransferase
glyceronephosphate O-acyltransferase
Identifiers
Symbol	GNPAT
NCBI gene	8443
HGNC	4416
OMIM	602744
RefSeq	NM_014236
UniProt	O15228
Other data
EC number	2.3.1.42
Locus	Chr. 1 q42
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Glyceronephosphate O-acyltransferase is an enzyme associated with rhizomelic chondrodysplasia punctata type 2.^[1]

The gene encoding it, GNPAT, is located on chromosome 1 on the plus strand. The gene C1orf131 is located directly upstream of it, and the closest downstream gene is EXOC8.^[2]

References

^ Velišek J, Cejpek K (2011). "Biosynthesis of Food Constituents: Lipids. 2. Triacylglycerols, Glycerophospholipids, and Glyceroglycolipids". Czech J. Food Sci. 24 (6): 241–254. doi:10.17221/3321-CJFS. S2CID 73576606.
^ "GNPAT glyceronephosphate O-acyltransferase [ Homo sapiens (human) ]". Gene. National Center for Biotechnology Information. 26 January 2024. Gene ID 8443. Retrieved 27 February 2024.

External links

glycerone-phosphate+O-acyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[1] Velišek J, Cejpek K (2011). "Biosynthesis of Food Constituents: Lipids. 2. Triacylglycerols, Glycerophospholipids, and Glyceroglycolipids". Czech J. Food Sci. 24 (6): 241–254. doi:10.17221/3321-CJFS. S2CID 73576606.

[2] "GNPAT glyceronephosphate O-acyltransferase [ Homo sapiens (human) ]". Gene. National Center for Biotechnology Information. 26 January 2024. Gene ID 8443. Retrieved 27 February 2024.

[1]

[2]

Peroxisomal and lysosomal proteins
Enzymes	Mevalonate kinase Catalase Acetyl-CoA C-acyltransferase Alkylglycerone phosphate synthase Phytanoyl-CoA dioxygenase HSD17B4 AMACR
Transporters	SLC27A2
Structure/Peroxin	PEX1 PXMP3 PEX3 PEX5 PEX6 PEX7 PEX10 PEX11A PEX11B PEX11G PEX12 PEX13 PEX14 PEX16 PEX19 PEX26
LAMP	CD68 LAMP1 LAMP2 LAMP3
see also intermediates, disorders

Transferases: acyltransferases (EC 2.3)
2.3.1: other than amino-acyl groups	acetyltransferases: Acetyl-Coenzyme A acetyltransferase N-Acetylglutamate synthase Choline acetyltransferase Dihydrolipoyl transacetylase Acetyl-CoA C-acyltransferase Beta-galactoside transacetylase Chloramphenicol acetyltransferase N-acetyltransferase Serotonin N-acetyl transferase HGSNAT ARD1A Histone acetyltransferase P300/CBP NAT2 palmitoyltransferases: Carnitine O-palmitoyltransferase CPT1 CPT2 Serine C-palmitoyltransferase SPTLC1 SPTLC2 other: Acyltransferase like 2 Aminolevulinic acid synthase Beta-ketoacyl-ACP synthase Lecithin—cholesterol acyltransferase Glycerol-3-phosphate O-acyltransferase 1-acylglycerol-3-phosphate O-acyltransferase 2-acylglycerol-3-phosphate O-acyltransferase ABHD5
2.3.2: Aminoacyltransferases	Gamma-glutamyl transpeptidase Peptidyl transferase Transglutaminase Tissue transglutaminase Keratinocyte transglutaminase Factor XIII
2.3.3: converted into alkyl on transfer	Citrate synthase Decylcitrate synthase Citrate (Re)-synthase Decylhomocitrate synthase 2-methylcitrate synthase 2-ethylmalate synthase 3-ethylmalate synthase ATP citrate lyase Malate synthase HMG-CoA synthase HMGCS2 2-hydroxyglutarate synthase 3-propylmalate synthase 2-isopropylmalate synthase Homocitrate synthase Sulfoacetaldehyde acetyltransferase

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)