Knucklehead
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Knucklehead may refer to:
- Harley-Davidson Knucklehead engine, introduced in 1936 as Model E, Harley-Davidson's first OHV engine
 - Knucklehead (2015 film), a film directed by Ben Bowman
 - Knucklehead (2010 film), a film produced by WWE Studios
 - Knucklehead (band), a Canadian punk rock group formed in Calgary, Canada in 1994
 - Knucklehead, B-side on the 1967 single "Soul Finger" by The Bar-Kays
 - Knucklehead, song by Grover Washington Jr., from the 1975 album Feels So Good
 - Knuckleheads, 2012 Canadian animated series
 - Knuckleheads Saloon, Kansas City, Missouri (where Karla Bonoff, Leon Redbone, and others have appeared)
 - Knuckle Heads, 1992 arcade game by Namco
 - Knuckleheads, 2008 platform game by Nitrome Limited
 - Knuckleheads Indoor Amusement Park, at Wisconsin Dells Parkway, Lake Delton, Wisconsin
 - Knucklehedz, member of hip hop collective Hit Squad
 
Characters
- Knucklehead, the Mascot of the band Five Finger Death Punch
 - Knucklehead Smiff, ventriloquist dummy of Paul Winchell
 - Knucklehead, from The Pee-wee Herman Show stage show and the Pee-wee's Playhouse television series
 - Knucklehead, from the anime Battle Angel Alita
 - The Knuckleheads, nickname of The Three Stooges