Misonidazole

Misonidazole
Names
	IUPAC name (RS)-1-Methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol
Identifiers
CAS Number	13551-87-6 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL42161 ;
ChemSpider	24317 ;
ECHA InfoCard	100.033.559
EC Number	236-931-6;
KEGG	D05052 ;
MeSH	D008920
PubChem CID	26105;
UNII	8FE7LTN8XE ;
CompTox Dashboard (EPA)	DTXSID80864420 ;
	InChI InChI=1S/C7H11N3O4/c1-14-5-6(11)4-9-3-2-8-7(9)10(12)13/h2-3,6,11H,4-5H2,1H3 Key: OBBCSXFCDPPXOL-UHFFFAOYSA-N ; InChI=1/C7H11N3O4/c1-14-5-6(11)4-9-3-2-8-7(9)10(12)13/h2-3,6,11H,4-5H2,1H3 Key: OBBCSXFCDPPXOL-UHFFFAOYAQ;
	SMILES COCC(CN1C=CN=C1[N+](=O)[O-])O;
Properties
Chemical formula	C7H11N3O4
Molar mass	201.182 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Misonidazole is a radiosensitizer that was investigated in clinical trials. It was used in these trials for radiation therapy to cause normally resistant hypoxic tumor cells to become sensitive to the treatment.^[1]^[2]

References

^ Meißner, Rebecca; Feketeová, Linda; Illenberger, Eugen; Denifl, Stephan (2019). "Reactions in the Radiosensitizer Misonidazole Induced by Low-Energy (0–10 eV) Electrons". International Journal of Molecular Sciences. 20 (14): 3496. doi:10.3390/ijms20143496. PMC 6678818. PMID 31315268.
^ Overgaard, Jens (2011). "Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck – A systematic review and meta-analysis". Radiotherapy and Oncology. 100 (1): 22–32. doi:10.1016/j.radonc.2011.03.004. PMID 21511351.