Tinidazole
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| Trade names | Fasigyn, Simplotan, Tindamax |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a604036 |
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| Routes of administration | By mouth[1] |
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| Pharmacokinetic data | |
| Protein binding | 12% |
| Metabolism | Liver (CYP3A4) |
| Elimination half-life | 12–14 hours |
| Excretion | Urine (20–25%), feces (12%) |
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| ECHA InfoCard | 100.039.089 |
| Chemical and physical data | |
| Formula | C8H13N3O4S |
| Molar mass | 247.27 g·mol−1 |
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Tinidazole, sold under the brand name Tindamax among others, is a medication used against protozoan infections. It is widely known throughout Europe and the developing world as a treatment for a variety of anaerobic amoebic and bacterial infections. It was developed in 1972 and is a prominent member of the nitroimidazole antibiotic class.[2]
It is on the World Health Organization's List of Essential Medicines.[3]
Medical uses
Tinidazole may be a therapeutic alternative in the setting of metronidazole intolerance. Tinidazole is used to treat Helicobacter pylori, Amoebic dysentery, Giardia and Trichomonas vaginalis.[4]
Side effects
Drinking alcohol while taking tinidazole causes an unpleasant disulfiram-like reaction, which includes nausea, vomiting, headache, increased blood pressure, flushing, and shortness of breath.
Pharmacology
Pharmacokinetics
Elimination half-life is 13.2 ± 1.4 hours. Plasma half-life is 12 to 14 hours.
History
Tinidazole was approved for treatment of bacterial vaginosis in the United States in 2007.[1]
See also
References
- ^ a b "Tinidazole". AdisInsight. 2 October 2021. Retrieved 26 February 2025.
- ^ Ebel K, Koehler H, Gamer AO, Jäckh R (2002). "Imidazole and Derivatives.". In Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH. doi:10.1002/14356007.a13_661. ISBN 3527306730.
- ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
- ^ Edwards DI (January 1993). "Nitroimidazole drugs--action and resistance mechanisms. I. Mechanisms of action". The Journal of Antimicrobial Chemotherapy. 31 (1): 9–20. doi:10.1093/jac/31.1.9. PMID 8444678.