Western Canada Rugby Football Union joined the CRU and challenged for the Grey Cup. The Edmonton Eskimos became the first Western team to play in a Grey Cup game, but lost to the Toronto Argonauts 23–0.
Rule changes included reducing players from 14 to 12 per side; putting ball into play by snapping it back; limit of 18 players with substitutes permitted freely.
Regular season
Final regular season standings
Note: GP = Games Played, W = Wins, L = Losses, T = Ties, PF = Points For, PA = Points Against, Pts = Points
*Bold text means that they have clinched the playoffs
Saskatchewan Rugby Football Union | Team | GP | W | L | T | PF | PA | Pts |
| Southern Saskatchewan |
| Regina Rugby Club | 4 | 4 | 0 | 0 | 86 | 11 | 8 |
| Regina Boat Club | 4 | 2 | 2 | 0 | 34 | 28 | 4 |
| Moose Jaw Millers | 4 | 0 | 4 | 0 | 12 | 93 | 0 |
| Northern Saskatchewan |
| Saskatoon Quakers | 3 | 2 | 1 | 0 | 43 | 18 | 4 |
| University of Saskatchewan Varsity | 3 | 1 | 2 | 0 | 18 | 43 | 2 |
* Final game of the season was cancelled - not necessary
League Champions
Grey Cup playoffs
Note: All dates in 1921
SRFU Playoff
| Date | Away | Home |
| November 4 | Regina Rugby Club 6 | Saskatoon 9 |
- Regina won the first game (score 10 to 8) played on October 29. After a successful protest, the game was replayed on November 4.
- Saskatoon advances to the WCRFU semifinal
Eastern semifinal
- Toronto Argonauts advance to the Eastern Final.[4]
Eastern final
- Toronto Argonauts advance to the Grey Cup.
Western semifinal
[5]
Western final
- Edmonton advances to the Grey Cup
Playoff bracket
| Quarterfinals | | | Semifinals | | | Grey Cup final | |
| | | | | | | | | | | | | | |
| ORFU | Toronto Parkdale | | | | |
|
| | BYE | | |
| | ORFU | Toronto Parkdale | 8 | |
| EAST | |
| | | IRFU | Toronto Argonauts | 16 | |
| IRFU | Toronto Argonauts | 20 | |
| |
| CIRFU | University of Toronto | 12 | |
| | IRFU | Toronto Argonauts | 23 | |
| | |
| | | ARFU | Edmonton Eskimos | 0 | |
| ARFU | Edmonton Eskimos | | | |
| |
| | BYE | | |
| | ARFU | Edmonton Eskimos | 16 | |
| WEST | |
| | | MRFU | Winnipeg Victorias | 6 | |
| MRFU | Winnipeg Victorias | 16 | |
| |
| SRFU | Saskatoon Quakers | 1 | |
Grey Cup Championship
1921 Toronto Globe Eastern All-Stars
NOTE: During this time most players played both ways, so the All-Star selections do not distinguish between some offensive and defensive positions.
- FW - Warren Synder, University of Toronto
- HB - Harry Batstone, Toronto Argonauts
- HB - Joe Breen, Toronto Parkdale
- HB - Lionel Conacher, Toronto Argonauts
- QB - Johnny Evans, Queen's University
- QB - Hugh Cochrane, Toronto Argonauts
- C - Lionel Shoebottom, Toronto Parkdale
- C - Jimmy Douglas, Toronto Argonauts
- G - R. McCombe, McGill University
- G - Harold Pugh, Toronto Argonauts
- G - ???, Hamilton Tigers
- T - Doug Ambridge, McGill University
- T - John McKelvey, Queen's University
- T - Alex Romeril, Toronto Argonauts
- E - Ernie Rolph, University of Toronto
- E - Bud Thomas, Ottawa Rough Riders
References