The 2000 Duke Blue Devils football team represented Duke University as a member of the Atlantic Coast Conference (ACC) during the 2000 NCAA Division I-A football season. Led by second-year head coach Carl Franks, the Blue Devils compiled an overall record of 0–11 with a mark of 0–8 in conference play, placing last out of nine teams in the ACC. The team played home games at Wallace Wade Stadium in Durham, North Carolina. 
 Schedule
 | Date | Time | Opponent | Site | TV | Result | Attendance | Source | 
|---|
| September 2 | 6:00 pm | East Carolina* |  |  | L 0–38 | 30,224 | [1] | 
 | September 9 | 1:00 pm | at Northwestern* |  |  | L 5–38 | 23,209 |  | 
 | September 16 | 6:00 pm | Virginia | - Wallace Wade Stadium
 - Durham, NC
 
  |  | L 10–26 | 18,776 |  | 
 | September 23 | 7:00 pm | at Vanderbilt* |  |  | L 7–26 | 25,486 | [2] | 
 | September 30 | 12:00 pm | No. 7 Clemson | - Wallace Wade Stadium
 - Durham, NC
 
  | JPS | L 22–52 | 16,872 |  | 
 | October 14 | 7:00 pm | at No. 5 Florida State |  | PPV | L 14–63 | 80,280 |  | 
 | October 21 | 12:00 pm | at Georgia Tech |  | JPS | L 10–45 | 36,908 |  | 
 | October 28 | 12:00 pm | Maryland | - Wallace Wade Stadium
 - Durham, NC
 
  | JPS | L 9–20 | 20,033 |  | 
 | November 4 | 12:00 pm | at Wake Forest |  | JPS | L 26–28 | 19,224 |  | 
 | November 11 | 1:00 pm | at NC State |  |  | L 31–35 | 51,680 |  | 
 | November 18 | 12:00 pm | North Carolina  |  | JPS | L 21–59 | 24,673 |  | 
 - *Non-conference game
  Homecoming- Rankings from AP Poll released prior to the game
 - All times are in Eastern time
 
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 Roster
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