2000 SMU Mustangs football team

The 2000 SMU Mustangs football team represented Southern Methodist University (SMU) as a member the Western Athletic Conference (WAC) during the 2000 NCAA Division I-A football season. Led by fourth-year head coach Mike Cavan, the Mustangs compiled an overall record of 3–9 with a mark of 2–6 in conference play, tying for sixth place in the WAC.

Date	Time	Opponent	Site	TV	Result	Attendance
September 2	6:00 p.m.	Kansas*	Gerald J. Ford Stadium University Park, TX		W 31–17	32,267
September 9	8:05 p.m.	at UTEP	Sun Bowl El Paso, TX	KSTR	L 20–37	31,483
September 16	6:00 p.m.	at NC State*	Carter–Finley Stadium Raleigh, NC		L 0–41	50,034
September 23	6:00 p.m.	Tulane*	Gerald J. Ford Stadium University Park, TX		L 17–29	26,375
September 30	7:00 p.m.	at Houston*	Robertson Stadium Houston, TX (rivalry)		L 15–17	17,496
October 7	6:00 p.m.	San Jose State	Gerald J. Ford Stadium University Park, TX		L 10–35	16,821
October 14	11:05 p.m.	at Hawaii	Aloha Stadium Honolulu, HI	KSTR	L 15–30	36,635
October 28	11:00 a.m.	Nevada	Gerald J. Ford Stadium University Park, TX		W 21–7	14,747
November 4	2:00 p.m.	at Rice	Rice Stadium Houston, TX (rivalry)		L 14–43	11,418
November 11	6:00 p.m.	Tulsa	Gerald J. Ford Stadium University Park, TX	KSTR	W 24–20	14,127
November 18	6:00 p.m.	at Fresno State	Bulldog Stadium Fresno, CA	KSTR	L 7–14	40,184
November 24	7:30 p.m.	No. 13 TCU	Gerald J. Ford Stadium University Park, TX (rivalry)		L 7–62	26,551
*Non-conference game Homecoming Rankings from AP Poll released prior to the game All times are in Central time