| Date | Time | Opponent | Rank# | Site | Result | Attendance | Winning Pitcher | Losing Pitcher |
| February 8* | 8:30 PM | Utah State Aggies | #6 | Big League Dreams • Palm Springs, CA | W 8-0(5) | 142 | A. Ward | S. Ellingsworth |
| February 8* | 11:00 PM | UC Davis Aggies | #6 | Big League Dreams • Palm Springs, CA | W 5-2 | 134 | M. Rhodes | J. Hancock |
| February 9* | 3:30 PM | #20 Oregon Ducks | #6 | Big League Dreams • Palm Springs, CA | W 5-0 | 221 | A. Ward | A. Cook |
| February 9* | 9:00 PM | Cal Poly Mustangs | #6 | Big League Dreams • Palm Springs, CA | W 8-0(5) | - | M. Rhodes | H. Pena |
| February 10* | 12:30 PM | Oregon St. Beavers | #6 | Big League Dreams • Palm Springs, CA | W 8-1 | - | A. Ward | K. Dyer |
| USF Tournament |
| February 16* | 4:00 PM | Florida Gulf Coast Eagles | #4 | USF Softball Stadium • Tampa, FL | W 6-2 | 304 | A. Ward | D. Frantz |
| February 16* | 8:00 PM | Hofstra Pride | #4 | USF Softball Stadium • Tampa, FL | W 6-1 | - | M. Rhodes | K. Lotti |
| February 17* | 2:00 PM | South Florida Bulls | #4 | USF Softball Stadium • Tampa, FL | L 1-4 | - | C. Mosch | A. Ward |
| February 17* | 11:30 PM | Ole Miss Rebels | #4 | USF Softball Stadium • Tampa, FL | W 2-0 | 197 | A. Ward | T. Willitt |
| February 18* | 9:30 AM | Florida A&M Rattlers | #2 | USF Softball Stadium • Tampa, FL | W 5-1 | - | A. Ward | T. Chan |
| Tennessee Classic |
| February 21* | 5:00 PM | BYU Cougars | #5 | Lee Stadium • Knoxville, TN | W 8-2 | 495 | A. Ward | C. Trice |
| February 22* | 7:30 PM | Virginia Cavaliers | #5 | Lee Stadium • Knoxville, TN | W 8-0(5) | - | M. Rhodes | K. Wilburn |
| February 23* | 2:30 PM | Wagner Seahawks | #5 | Lee Stadium • Knoxville, TN | W 14-0(5) | - | M. Rhodes | D. Wagoner |
| February 23* | 5:00 PM | ULM Warhawks | #5 | Lee Stadium • Knoxville, TN | W 4-0 | 729 | A. Ward | K. Causey |
| February 24* | 12:00 PM | Virginia Cavaliers | #5 | Lee Stadium • Knoxville, TN | W 5-1 | - | A. Ward | K. Wilburn |
| NFCA Leadoff Classic |
| February 29* | 11:00 AM | Charlotte 49ers | #4 | South Commons • Columbus GA | W 8-4 | - | M. Rhodes | K. Hackett |
| February 29* | 4:00 PM | Hofstra Pride | #4 | South Commons • Columbus, GA | W 5-2 | - | M. Rhodes | S. Michalowski |
| March 1* | 11:00 AM | Florida St. Seminoles | #4 | South Commons • Columbus, GA | W 8-5 | - | A. Ward | T. Gober |
| March 1* | 4:00 PM | Illinois St. Redbirds | #4 | South Commons • Columbus, GA | W 5-2 | - | A. Ward | R. Smith |
| March 2* | 10:00 AM | Nebraska Cornhuskers | #4 | South Commons • Columbus, GA | W 9-0(6) | - | M. Rhodes | M. Hill |
| |
| March 5* | 6:00 PM | Tennessee Tech Golden Eagles | #4 | Lee Stadium • Knoxville, TN | W 1-0 | 759 | A. Ward | S. Street |
| March 8 | 2:00 PM | #2 Alabama Crimson Tide | #4 | Rhoads Stadium • Tuscaloosa, AL | L 0-8(6) | 2,252 | K. Dunne | A. Ward |
| March 9 | 1:30 PM | #2 Alabama Crimson Tide | #4 | Rhoads Stadium • Tuscaloosa, AL | L 2-13(5) | 2,245 | C. Owens | M. Rhodes |
| March 9 | 4:00 PM | #2 Alabama Crimson Tide | #4 | Rhoads Stadium • Tuscaloosa, AL | W 7-3 | 2,245 | M. Rhodes | K. Dunne |
| March 12* | 5:00 PM | Tennessee St. Tigers | #6 | Lee Stadium • Knoxville, TN | W 9-1(6) | 661 | M. Rhodes | A. Vaught |
| March 12* | 7:30 PM | Tennessee St. Tigers | #6 | Lee Stadium • Knoxville, TN | W 4-1 | 661 | A. Ward | A. Vaught |
| March 15 | 6:00 PM | Kentucky Wildcats | #6 | Lee Stadium • Knoxville, TN | L 0-2 | 725 | A. Matousek | M. Rhodes |
| March 16 | 1:00 PM | Kentucky Wildcats | #6 | Lee Stadium • Knoxville, TN | W 5-1 | 683 | A. Ward | J. Young |
| March 16 | 3:30 PM | Kentucky Wildcats | #6 | Lee Stadium • Knoxville, TN | W 2-0 | 683 | M. Rhodes | A. Matousek |
| March 19 | 3:00 PM | South Carolina Gamecocks | #8 | Beckham Field • Columbia, SC | W 2-0(9) | - | A. Ward | M. Hendon |
| March 19 | 5:30 PM | South Carolina Gamecocks | #8 | Beckham Field • Columbia, SC | Canceled | - | - | - |
| March 21 | 5:00 PM | Arkansas Razorbacks | #8 | Lady Back Yard • Fayetteville, AR | L 2-5 | - | K. Henry | A. Ward |
| March 21 | 7:30 PM | Arkansas Razorbacks | #8 | Lady Back Yard • Fayetteville, AR | W 11-2 | - | M. Rhodes | K. Henry |
| March 22 | 12:00 PM | Arkansas Razorbacks | #8 | Lady Back Yard • Fayetteville, AR | W 4-2 | - | M. Rhodes | K. Henry |
| March 25* | 5:00 PM | Lipscomb Bison | #9 | Lee Stadium • Knoxville, TN | W 8-0(5) | 605 | A. Ward | C. Campbell |
| March 25* | 7:30 PM | Lipscomb Bison | #9 | Lee Stadium • Knoxville, TN | W 4-1 | 605 | M. Rhodes | A. Jacobson |
| March 29 | 5:00 PM | Auburn Tigers | #9 | Jane B. Moore Field • Auburn, AL | W 8-4 | 817 | A. Ward | A. Thompson |
| March 29 | 7:30 PM | Auburn Tigers | #9 | Jane B. Moore Field • Auburn, AL | L 0-1 | 817 | B. Day | M. Rhodes |
| March 30 | 12:00 PM | Auburn Tigers | #9 | Jane B. Moore Field • Auburn, AL | L 1-2(8) | 521 | A. Thompson | M. Rhodes |
| April 2* | 5:00 PM | ETSU Buccaneers | #12 | Lee Stadium • Knoxville, TN | W 4-3 | 574 | A. Ward | M. Hardy |
| April 2* | 7:30 PM | ETSU Buccaneers | #12 | Lee Stadium • Knoxville, TN | W 7-0 | 574 | A. Ward | M. Hardy |
| April 5 | 1:00 PM | #14 Georgia Bulldogs | #12 | Lee Stadium • Knoxville, TN | W 6-4 | 1,162 | M. Rhodes | S. McCloud |
| April 5 | 3:30 PM | #14 Georgia Bulldogs | #12 | Lee Stadium • Knoxville, TN | W 9-0(6) | 1,162 | M. Rhodes | K. Gaskill |
| April 6 | 12:00 PM | #14 Georgia Bulldogs | #12 | Lee Stadium • Knoxville, TN | W 5-1 | 878 | M. Rhodes | T. Schlopy |
| April 8* | 3:30 PM | Liberty Flames | #10 | Lee Stadium • Knoxville, TN | W 8-2 | 476 | M. Rhodes | S. Ellis |
| April 8* | 6:00 PM | Liberty Flames | #10 | Lee Stadium • Knoxville, TN | W 7-1 | 476 | A. Ward | D. Wheeler |
| April 9* | 4:00 PM | Western Carolina Catamounts | #10 | Lee Stadium • Knoxville, TN | W 11-0(5) | 497 | M. Rhodes | L. Ross |
| April 9* | 6:30 PM | Western Carolina Catamounts | #10 | Lee Stadium • Knoxville, TN | W 11-3(5) | 497 | A. Ward | M. Tating |
| April 12 | 3:00 PM | #1 United States Olympic Team (Exhibition) | #10 | Lee Stadium • Knoxville, TN | L 2-4 | 1,622 | M. Abbott | D. Pieroni |
| April 16 | 3:00 PM | Ole Miss Rebels | #9 | Lee Stadium • Knoxville, TN | L 0-1 | - | T. Willitt | M. Rhodes |
| April 16 | 5:30 PM | Ole Miss Rebels | #9 | Lee Stadium • Knoxville, TN | W 6-2 | - | A. Ward | B. Nye |
| April 19 | 1:00 PM | #11 LSU Tigers | #9 | Lee Stadium • Knoxville, TN | W 8-0(5) | 1,066 | A. Ward | D. Hofer |
| April 19 | 3:30 PM | #11 LSU Tigers | #9 | Lee Stadium • Knoxville, TN | L 2-8 | 1,066 | C. Trahan | M. Rhodes |
| April 20 | 1:00 PM | #11 LSU Tigers | #9 | Lee Stadium • Knoxville, TN | W 5-4 | - | A. Ward | T. Garcia |
| April 22* | 2:00 PM | Austin Peay Govs | #10 | Lee Stadiym • Knoxville, TN | W 9-1(5) | - | A. Ward | A. Mabry |
| April 22* | 4:30 PM | Austin Peay Govs | #10 | Lee Stadium • Knoxville, TN | W 14-1(5) | - | A. Ward | M. Williams |
| April 26 | 4:00 PM | #23 Mississippi St. Bulldogs | #10 | MSU Softball Field • Starkville, MS | L 1-2 | 507 | M. Flesher | A. Ward |
| April 26 | 6:30 PM | #23 Mississippi St. Bulldogs | #10 | MSU Softball Field • Starkville, MS | W 8-6 | 507 | A. Ward | K. Nurnberg |
| April 27 | 2:00 PM | #23 Mississippi St. Bulldogs | #10 | MSU Softball Field • Starkville, MS | Canceled | - | - | - |
| May 3 | 4:00 PM | #2 Florida Gators | #12 | Lee Stadium • Knoxville, TN | L 2-4 | 1,164 | S. Nelson | A. Ward |
| May 3 | 6:30 PM | #2 Florida Gators | #12 | Lee Stadium • Knoxville, TN | L 5-6(11) | 1,164 | S. Nelson | M. Rhodes |
| May 4 | 1:00 PM | #2 Florida Gators | #12 | Lee Stadium • Knoxville, TN | L 3-5 | 1,157 | S. Nelson | M. Rhodes |
| SEC Tournament |
| May 8 | 12:00 PM | #25 Georgia Bulldogs | #14 | Tiger Park • Baton Rouge, LA | W 5-2 | - | M. Rhodes | C. Hamilton |
| May 9 | 5:00 PM | #1 Florida Gators | #14 | Tiger Park • Baton Rouge, LA | L 1-6 | - | S. Nelson | M. Rhodes |
| NCAA Knoxville Regional |
| May 16 | 5:00 PM | Winthrop Eagles | #13 | Lee Stadium • Knoxville, TN | W 3-0 | 628 | M. Rhodes | C. Woolridge |
| May 17 | 12:00 PM | #17 Virginia Tech Hokies | #13 | Lee Stadium • Knoxville, TN | L 0-2 | 668 | A. Tincher | M. Rhodes |
| May 17 | 6:30 PM | Louisville Cardinals | #13 | Lee Stadium • Knoxville, TN | W 8-1 | 668 | M. Rhodes | K. Wadwell |
| May 18 | 3:00 PM | #17 Virginia Tech Hokies | #13 | Lee Stadium • Knoxville, TN | W 7-1 | 637 | M. Rhodes | A. Tincher |
| May 18 | 5:30 PM | #17 Virginia Tech Hokies | #13 | Lee Stadium • Knoxville, TN | L 0-4 | 637 | A. Tincher | M. Rhodes |
| *Non-Conference Game. #Rankings from NFCA released prior to game.All times are in Eastern Time Zone. |
