ALPHA (drug)

ALPHA
Clinical data
Other names	3,4-Methylenedioxy-α-ethylbenzylamine; 1-Amino-1-(3,4-methylenedioxyphenyl)propane
Routes of; administration	Oral
Drug class	Unknown
ATC code	None;
Pharmacokinetic data
Duration of action	~3 hours
Identifiers
	IUPAC name 1-(1,3-Benzodioxol-5-yl)propan-1-amine;
CAS Number	127292-42-6 ;
PubChem CID	14647596;
ChemSpider	11853242 ;
UNII	AC10C1L8VO;
CompTox Dashboard (EPA)	DTXSID701027199 DTXSID70562589, DTXSID701027199 ;
Chemical and physical data
Formula	C10H13NO2
Molar mass	179.219 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(N)c1ccc2OCOc2c1;
	InChI InChI=1S/C10H13NO2/c1-2-8(11)7-3-4-9-10(5-7)13-6-12-9/h3-5,8H,2,6,11H2,1H3 ; Key:VEOUOCLRLNJOLJ-UHFFFAOYSA-N ;
	(verify)

ALPHA, also known as 3,4-methylenedioxy-α-ethylbenzylamine, is a psychoactive drug of the substituted benzylamine group and a positional isomer of 3,4-methylenedioxyamphetamine (MDA).^[1]^[2] It is also a benzylamine analogue of 3,4-methylenedioxyamphetamine (MDA).^[1]^[2] ALPHA was first synthesized by Alexander Shulgin.^[1]^[2] In his book PIHKAL on the MDA page, the threshold dosage is listed as 10 mg.^[1] At mild threshold dosages (around 10 mg) there are eyes-closed "dreams" with some body tingling, at higher doses (up to 140 mg) was reported to produce a pleasant, positive feeling.^[1] This compound is not anoretic at any dose.^[1] Its duration is about 3 hours.^[1] Very little data exists about the pharmacological properties, metabolism, and toxicity of ALPHA.^[1]^[2] The drug was encountered as a novel designer drug by 1996.^[3]^[4]

References

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k MDA Entry in PIHKAL
^ ^a ^b ^c ^d Shulgin A, Manning T, Daley PF (2011). The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds. Vol. 1. Berkeley: Transform Press. ISBN 978-0-9630096-3-0.
^ King L, Poortman-van der Meer A, Huizer H (1996). "1-Phenylethylamines: a new series of illicit drugs?". Forensic Science International. 77 (3): 141–149. doi:10.1016/0379-0738(95)01852-2. Retrieved 9 April 2025.
^ King LA (1996). "Designer drugs related to amphetamine (1990-1996)". Journal of the Clandestine Laboratory Investigating Chemists Association. 6 (3): 15–16.