| Title | Director | Cast | Genre | Notes |
| Saigon | Leslie Fenton | Alan Ladd, Veronica Lake, Douglas Dick | Film noir | Paramount |
| The Sainted Sisters | William D. Russell | Veronica Lake, Joan Caulfield, George Reeves | Comedy | Paramount |
| The Saxon Charm | Claude Binyon | Robert Montgomery, Susan Hayward, John Payne | Film noir | Universal |
| Scudda Hoo! Scudda Hay! | F. Hugh Herbert | June Haver, Lon McCallister, Walter Brennan | Comedy | 20th Century Fox |
| Sealed Verdict | Lewis Allen | Ray Milland, Florence Marly, Broderick Crawford | Drama | Paramount |
| The Search | Fred Zinnemann | Montgomery Clift, Aline MacMahon, Jarmila Novotná | Drama | MGM |
| Secret Service Investigator | R. G. Springsteen | Lloyd Bridges, Lynne Roberts, George Zucco | Crime | Republic |
| Shaggy | Robert Emmett Tansey | Brenda Joyce, Robert Shayne, Jody Gilbert | Drama | Paramount |
| Shanghai Chest | William Beaudine | Roland Winters, Mantan Moreland, Victor Sen Yung | Mystery | Monogram. Charlie Chan |
| Shed No Tears | Jean Yarbrough | June Vincent, Wallace Ford, Frank Albertson | Film noir | Eagle-Lion |
| Shep Comes Home | Ford Beebe | Robert Lowery, Margia Dean, Michael Whalen | Drama | Lippert |
| The Sheriff of Medicine Bow | Lambert Hillyer | Johnny Mack Brown, Raymond Hatton, Evelyn Finley | Western | Monogram |
| The Sign of the Ram | John Sturges | Susan Peters, Alexander Knox, Phyllis Thaxter | Film noir | Columbia |
| Silent Conflict | George Archainbaud | William Boyd, Virginia Belmont, Andy Clyde | Western | United Artists |
| Silver River | Raoul Walsh | Errol Flynn, Ann Sheridan, Thomas Mitchell | Western | Warner Bros. |
| Silver Trails | Christy Cabanne | Jimmy Wakely, Dub Taylor, Christine Larson | Western | Monogram |
| Singin' Spurs | Ray Nazarro | Kirby Grant, Patricia Barry, Lee Patrick | Musical western | Columbia |
| Sinister Journey | George Archainbaud | William Boyd, Elaine Riley, Andy Clyde | Western | United Artists |
| Sitting Pretty | Walter Lang | Robert Young, Maureen O'Hara, Clifton Webb | Comedy | 20th Century Fox |
| Six-Gun Law | Ray Nazarro | Charles Starrett, Nancy Saunders, Smiley Burnette | Western | Columbia |
| Sixteen Fathoms Deep | Irving Allen | Lloyd Bridges, Lon Chaney Jr., Tanis Chandler | Adventure | Monogram |
| Sleep, My Love | Douglas Sirk | Claudette Colbert, Don Ameche, Robert Cummings | Drama | United Artists |
| Slippy McGee | Albert H. Kelley | Don "Red" Barry, Dale Evans, Tom Brown | Crime | Republic |
| Smart Girls Don't Talk | Richard L. Bare | Virginia Mayo, Bruce Bennett, Robert Hutton | Crime | Warner Bros. |
| Smart Politics | Will Jason | June Preisser, Frankie Darro, Noel Neill | Musical | Monogram |
| Smart Woman | Edward A. Blatt | Constance Bennett, Brian Aherne, Barry Sullivan | Drama | Allied Artists |
| Smoky Mountain Melody | Ray Nazarro | Roy Acuff, Guinn "Big Boy" Williams, Russell Arms | Musical western | Columbia |
| Smugglers' Cove | William Beaudine | Leo Gorcey, Huntz Hall, Amelita Ward | Comedy | Monogram |
| The Snake Pit | Anatole Litvak | Olivia de Havilland, Leo Genn, Mark Stevens | Drama | 20th Century Fox; 6 Oscar nominations |
| So Evil My Love | Lewis Allen | Ray Milland, Geraldine Fitzgerald, Ann Todd | Drama | Paramount |
| So This Is New York | Richard Fleischer | Henry Morgan, Rudy Vallee, Virginia Grey | Comedy | United Artists |
| Sofia | John Reinhardt | Gene Raymond, Patricia Morison, Sigrid Gurie | Drama | Film Classics |
| Son of God's Country | R. G. Springsteen | Monte Hale, Pamela Blake, Paul Hurst | Western | Republic |
| A Song Is Born | Howard Hawks | Danny Kaye, Virginia Mayo, Tommy Dorsey, Benny Goodman | Musical | RKO. Featuring The Golden Gate Quartet |
| Song of the Drifter | Lambert Hillyer | Jimmy Wakely, Dub Taylor, Mildred Coles | Western | Monogram |
| Song of Idaho | Ray Nazarro | Kirby Grant, June Vincent, Dorothy Vaughan | Western | Columbia |
| Song of My Heart | Benjamin Glazer | Audrey Long, Frank Sundström, Cedric Hardwicke | Biographical | Allied Artists |
| Sons of Adventure | Yakima Canutt | Lynne Roberts, Russell Hayden, Grant Withers | Western | Republic |
| Sorry, Wrong Number | Anatole Litvak | Barbara Stanwyck, Burt Lancaster, Ann Richards | Film noir | Paramount |
| A Southern Yankee | Edward Sedgwick | Red Skelton, Brian Donlevy, Arlene Dahl | Comedy western | MGM |
| Speed to Spare | William Berke | Richard Arlen, Jean Rogers, Richard Travis | Drama | Paramount |
| Stage Struck | William Nigh | Conrad Nagel, Kane Richmond, Audrey Long | Crime | Monogram |
| State of the Union | Frank Capra | Spencer Tracy, Katharine Hepburn, Van Johnson | Drama | MGM |
| Station West | Sidney Lanfield | Dick Powell, Jane Greer, Agnes Moorehead | Western | RKO |
| Strange Gamble | George Archainbaud | William Boyd, Elaine Riley, Rand Brooks | Western | United Artists |
| The Strange Mrs. Crane | Sam Newfield | Marjorie Lord, Robert Shayne, Pierre Watkin | Film noir | Eagle-Lion |
| The Strawberry Roan | John English | Gene Autry, Gloria Henry, Jack Holt | Western | Columbia |
| Street Corner | Albert H. Kelley | Johnny Duncan, Marcia Mae Jones, Eddie Gribbon | Drama | Independent |
| The Street with No Name | William Keighley | Mark Stevens, Richard Widmark, Lloyd Nolan | Film noir | 20th Century Fox |
| Strike It Rich | Lesley Selander | Rod Cameron, Bonita Granville, Stuart Erwin | Comedy | Allied Artists |
| Summer Holiday | Rouben Mamoulian | Mickey Rooney, Gloria DeHaven, Frank Morgan | Musical | MGM |
| Sundown in Santa Fe | R. G. Springsteen | Allan Lane, Eddy Waller, Roy Barcroft | Western | Republic |
| Sunset Carson Rides Again | Oliver Drake | Sunset Carson, Dan White, Ron Ormond | Western | Astor |
| Sword of the Avenger | John Reinhardt | Sigrid Gurie, Ramon Delgado, Ralph Morgan | Adventure | Film Classics |
| The Swordsman | Joseph H. Lewis | Larry Parks, Ellen Drew, George Macready | Adventure | Columbia |