| Title | Director | Cast | Genre | Notes |
| Sabaka | Frank Ferrin | Boris Karloff, June Foray, Reginald Denny | Adventure | United Artists |
| Sabrina | Billy Wilder | Humphrey Bogart, Audrey Hepburn, William Holden | Romantic comedy | Paramount; 6 Oscar nominations; remade in 1995 |
| Salt of the Earth | Herbert J. Biberman | Rosaura Revueltas, Will Geer, David Bauer | Drama | Independent. Subject of One of the Hollywood Ten |
| The Saracen Blade | William Castle | Ricardo Montalbán, Betta St. John, Carolyn Jones | Adventure | Columbia |
| Saskatchewan | Raoul Walsh | Alan Ladd, Shelley Winters, J. Carrol Naish | Western | Universal |
| Secret of the Incas | Jerry Hopper | Charlton Heston, Robert Young, Nicole Maurey | Adventure | Paramount |
| Security Risk | Harold D. Schuster | John Ireland, Dorothy Malone, Dolores Donlon | Thriller | Allied Artists |
| Seven Brides for Seven Brothers | Stanley Donen | Howard Keel, Jane Powell, Russ Tamblyn, Jeff Richards, Julie Newmar, Ruta Lee | Musical | MGM; 5 Oscar nominations |
| The Shanghai Story | Frank Lloyd | Ruth Roman, Edmond O'Brien, Richard Jaeckel | Drama | Republic |
| She Couldn't Say No | Lloyd Bacon | Robert Mitchum, Jean Simmons, Arthur Hunnicutt | Comedy | RKO. Bacon's final film |
| Shield for Murder | Edmond O'Brien | Edmond O'Brien, Marla English, John Agar | Film noir | United Artists |
| Siege at Red River | Rudolph Mate | Van Johnson, Joanne Dru, Richard Boone | Western | 20th Century Fox |
| Sign of the Pagan | Douglas Sirk | Jack Palance, Jeff Chandler, Rita Gam | Adventure | Universal |
| Silent Raiders | Richard Bartlett | Richard Bartlett, Dean Fredericks | War | Lippert |
| The Silver Chalice | Victor Saville | Paul Newman, Virginia Mayo, Pier Angeli | Drama | Warner Bros.; first film for Newman |
| Silver Lode | Allan Dwan | Dan Duryea, John Payne, Lizabeth Scott | Western | RKO |
| Sitting Bull | Sidney Salkow | Dale Robertson, Mary Murphy, J. Carrol Naish | Western | United Artists |
| The Snow Creature | W. Lee Wilder | Paul Langton, Teru Shimada, William Phipps | Science fiction | United Artists |
| Southwest Passage | Ray Nazarro | Joanne Dru, Rod Cameron, John Ireland | Western | United Artists |
| A Star Is Born | George Cukor | Judy Garland, James Mason, Charles Bickford, Jack Carson, Tommy Noonan | Musical | Warner Bros. remake of 1937 film; 6 Oscar nominations; remade in 1976 |
| The Steel Cage | Walter Doniger | Maureen O'Sullivan, Lawrence Tierney, Paul Kelly | Drama | United Artists |
| The Student Prince | Richard Thorpe | Ann Blyth, Edmund Purdom, Louis Calhern, Edmund Gwenn, Betta St. John | Musical | MGM; vocals by Mario Lanza; based on the operetta |
| Suddenly | Lewis Allen | Frank Sinatra, Sterling Hayden, Nancy Gates | Crime drama | United Artists |
| Susan Slept Here | Frank Tashlin | Dick Powell, Debbie Reynolds, Anne Francis | Romantic comedy | RKO; Powell's final film |
| Tanganyika | André de Toth | Van Heflin, Ruth Roman, Howard Duff | Action | Universal |
| Target Earth | Sherman A. Rose | Richard Denning, Kathleen Crowley, Virginia Grey | Sci-fi | Allied Artists |
| Taza, Son of Cochise | Douglas Sirk | Rock Hudson, Barbara Rush, Rex Reason | Western | Universal |
| Tennessee Champ | Fred M. Wilcox | Shelley Winters, Keenan Wynn, Dewey Martin | Drama | MGM |
| Them! | Gordon Douglas | James Whitmore, Edmund Gwenn, Joan Weldon | Science fiction | Warner Bros. |
| There's No Business Like Show Business | Walter Lang | Ethel Merman, Donald O'Connor, Marilyn Monroe, Mitzi Gaynor, Dan Dailey, Johnnie Ray | Musical | 20th Century Fox; 3 Academy Award nominations |
| They Rode West | Phil Karlson | Robert Francis, Donna Reed, Philip Carey, May Wynn, John War Eagle | Western | Columbia |
| They Were So Young | Kurt Neumann | Raymond Burr, Scott Brady, Johanna Matz | Drama | Lippert |
| This Is My Love | Stuart Heisler | Linda Darnell, Faith Domergue, Dan Duryea | Drama | RKO |
| Three Coins in the Fountain | Jean Negulesco | Clifton Webb, Dorothy McGuire, Jean Peters, Rossano Brazzi | Drama | 20th Century Fox; Oscars for Cinematography and Song |
| Three Hours to Kill | Alfred L. Werker | Dana Andrews, Donna Reed, Dianne Foster | Western | Columbia |
| Three Young Texans | Henry Levin | Jeffrey Hunter, Keefe Brasselle, Mitzi Gaynor | Western | 20th Century Fox |
| Thunder Pass | Frank McDonald | Dane Clark, Dorothy Patrick, Andy Devine | Western | Lippert |
| Tobor the Great | Lee Sholem | Charles Drake, Karin Booth, Steven Geray | Sci-fi | Republic |
| Top Banana | Alfred E. Green | Phil Silvers, Rose Marie, Judy Lynn | Musical | United Artists. Based on stage musical |
| Track of the Cat | William Wellman | Robert Mitchum, Teresa Wright, Diana Lynn | Adventure | Warner Bros. |