Clofuperol

Clofluperol
Clinical data
Other namesSeperidol, R9298
Identifiers
  • 4-[4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H22ClF4NO2
Molar mass443.87 g·mol−1
3D model (JSmol)
  • C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(=O)C3=CC=C(C=C3)F
  • InChI=1S/C22H22ClF4NO2/c23-19-8-5-16(14-18(19)22(25,26)27)21(30)9-12-28(13-10-21)11-1-2-20(29)15-3-6-17(24)7-4-15/h3-8,14,30H,1-2,9-13H2
  • Key:LZFSKNPPWIFMFL-UHFFFAOYSA-N

Clofluperol is a neuroleptic tranquilizer of the butyrophenone class.[1][2][3] It has the same aromatic piperidinol moiety that is present in penfluridol and fluperamide. The structure can be seen to be a sort of hybrid between that of trifluperidol and haloperidol.

References

  1. ^ Bobon J, Pinchard A, Goffioul F, Devroye A, Bobon DP, Korn M (February 1968). "[Long-acting neuroleptics. I. Pilot study of clofluperol (R9298)]". Acta Neurologica et Psychiatrica Belgica (in French). 68 (2): 128–136. PMID 4972601.
  2. ^ Janssen PA, Allewijn FT (February 1969). "The distribution of the butyrophenones haloperidol, trifluperidol, moperone, and clofluperol in rats, and its relationship with their neuroleptic activity". Arzneimittel-Forschung. 19 (2): 199–208. PMID 5818759.
  3. ^ Mishkinsky J, Khazen K, Givant Y, Dikstein S (May 1969). "Sulman FG: Mammotropic and neuroleptic effects of butyrophenones in the rat". Archives Internationales de Pharmacodynamie et de Therapie. 179 (1): 94–105. PMID 5388566.
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