The final of the 2008-II Copa Mustang was played between Independiente Medellín and América de Cali. The first leg match was won by América de Cali by an early goal in the second half. In the second leg match, América de Cali were crowned champions of the 2008-II Copa Mustang championship, giving them the chance to participate in the Copa Libertadores 2009 (same way to Independiente Medellín and giving them the championship for the thirteenth time in their history. 
  Matches
 First leg match
     Second leg match
     References
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|  HonoursPlayersManagersPresidentsSeasonsInternational participationsRecords and statisticsCurrent season
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| Team |  | 
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| Home stadium |  | 
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| League Titles (15) |  | 
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| Second League Titles (1) |  | 
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| Copa Merconorte Titles (1) |  | 
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| Copa Simón Bolívar Titles (1) |  | 
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| Matches |  | 
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