| Name | Mark | System[nb 1] | From | To | Successor | Notes |
| Addyston and Ohio River Railroad | | | 1889 | 1914 | N/A |
| Adena Railroad | | W&LE | 1901 | 1916 | Wheeling and Lake Erie Railway |
| Adena, Cadiz and New Athens Railway | | W&LE | 1914 | 1917 | Wheeling and Lake Erie Railway |
| Akron and Barberton Belt Railroad | A&BB, ABB | ACY/ B&O/ ERIE/ PRR | 1902 | 1994 | Akron Barberton Cluster Railway |
| Akron Branch of the Cleveland and Pittsburgh Railroad | | PRR | 1851 | 1853 | Cleveland, Zanesville and Cincinnati Railroad |
| Akron, Canton and Youngstown Railroad | ACY | ACY | 1944 | 1982 | Norfolk and Western Railway |
| Akron, Canton and Youngstown Railway | ACY | ACY | 1907 | 1944 | Akron, Canton and Youngstown Railroad |
| Akron and Chicago Junction Railroad | | B&O | 1890 | 1915 | Baltimore and Ohio Railroad |
| Akron and New Castle Railroad | | ACY | 1892 | 1907 | Akron, Canton and Youngstown Railway |
| Akron and Pittsburgh Railroad | | ACY | 1895 | 1899 | Northern Ohio Railway |
| Akron Terminal Railway | | ACY/ B&O/ ERIE/ PRR | 1901 | 1901 | Barberton, Akron and Eastern Railway |
| Akron Transfer Railroad | | ACY | 1891 | 1902 | Richland and Mahoning Railway |
| Akron Union Passenger Depot Company | | B&O/ PRR | 1891 | 1975 | N/A |
| Alliance and Lake Erie Railroad | | NYC | 1878 | 1882 | Cleveland, Youngstown and Pittsburgh Railway |
| Alliance, Niles and Ashtabula Railroad | | PRR | 1881 | 1887 | Ashtabula, Niles and Youngstown Railroad |
| Alliance and Northern Railroad | | NYC | 1891 | 1902 | Lake Erie, Alliance and Wheeling Railroad |
| American Central Railway | | NKP | 1859 | 1864 | Cleveland, Fort Wayne and Chicago Railroad |
| American Midland Railway | | | 1889 | 1890 | Findlay and Western Railroad |
| Ann Arbor Railroad | AA | AA | 1895 | 1976 | Consolidated Rail Corporation |
| Ashland and Western Railroad | | ERIE/ PRR | 1904 | 1906 | Ashland and Western Railway |
| Ashland and Western Railway | | ERIE/ PRR | 1906 | 1913 | Lorain, Ashland and Southern Railroad |
| Ashland and Wooster Railway | | ERIE/ PRR | 1897 | 1903 | Lake and River Railway |
| Ashtabula and New Lisbon Railroad | | ERIE, PRR | 1853 | 1870 | Ashtabula, Youngstown and Pittsburgh Railroad, Niles and New Lisbon Railway |
| Ashtabula, Niles and Youngstown Railroad | | PRR | 1887 | 1887 | Pittsburgh, Youngstown and Ashtabula Railroad |
| Ashtabula and Pittsburgh Railway | | PRR | 1878 | 1887 | Ashtabula, Niles and Youngstown Railroad |
| Ashtabula, Youngstown and Pittsburgh Railroad | | PRR | 1870 | 1878 | Ashtabula and Pittsburgh Railway |
| Athens, Amesville and Chauncey Railway | | C&O | 1903 | 1909 | Hocking Valley Railway |
| Atlantic and Great Western Railroad | | ERIE | 1871 | 1880 | New York, Pennsylvania and Ohio Railroad |
| Atlantic and Great Western Railroad | | ERIE | 1853 | 1865 | Atlantic and Great Western Railway |
| Atlantic and Great Western Railway | | ERIE | 1865 | 1871 | Atlantic and Great Western Railroad |
| Atlantic and Lake Erie Railway | | NYC | 1869 | 1876 | Ohio Central Railway |
| Baltimore and Ohio Railroad | B&O, BO | B&O | 1866 | 1987 | Chesapeake and Ohio Railway |
| Baltimore and Ohio and Chicago Railroad | | B&O | 1876 | 1949 | Baltimore and Ohio Railroad |
| Baltimore and Ohio Southwestern Railroad | | B&O | 1899 | 1949 | Baltimore and Ohio Railroad |
| Baltimore and Ohio Southwestern Railroad | | B&O | 1889 | 1893 | Baltimore and Ohio Southwestern Railway |
| Baltimore and Ohio Southwestern Railway | | B&O | 1893 | 1899 | Cincinnati, Portsmouth and Parkersburg Railway |
| Baltimore and Ohio Southwestern Terminal Company | | B&O | 1891 | 1899 | Baltimore and Ohio Southwestern Railroad |
| Baltimore and Ohio, Toledo and Michigan Railroad | | PRR | 1870 | 1871 | Toledo, Tiffin and Eastern Railroad |
| Baltimore, Pittsburgh and Chicago Railway | | B&O | 1872 | 1876 | Baltimore and Ohio and Chicago Railroad |
| Baltimore, Pittsburgh and Continental Railroad | | ERIE | 1871 | 1873 | Chicago and Atlantic Railway |
| Baltimore Short Line Railway | | B&O | 1870 | 1888 | Cincinnati, Washington and Baltimore Railroad |
| Barberton, Akron and Eastern Railway | | ACY/ B&O/ ERIE/ PRR | 1901 | 1902 | Barberton, Akron and Eastern Belt Line Railway |
| Barberton, Akron and Eastern Belt Line Railway | | ACY/ B&O/ ERIE/ PRR | 1902 | 1902 | Akron and Barberton Belt Railroad |
| Barberton Belt Line Railroad | | ACY/ B&O/ ERIE/ PRR | 1891 | 1902 | Akron and Barberton Belt Railroad |
| Barberton and Southern Railroad | | ACY/ B&O/ ERIE/ PRR | 1899 | 1905 | Akron and Barberton Belt Railroad |
| Bay Terminal Railroad | | | 1895 | 1955 | N/A |
| Bellaire, Beaver Valley and Shawnee Railway | | B&O | 1879 | 1882 | Wheeling and Cincinnati Mineral Railway |
| Bellaire and St. Clairsville Railway | | B&O | 1885 | 1888 | Central Ohio Railroad |
| Bellaire and St. Clairsville Narrow Gauge Railway | | B&O | 1876 | 1880 | St. Clairsville Railway |
| Bellaire and South Western Railway | | PRR | 1875 | 1882 | Bellaire, Zanesville and Cincinnati Railway |
| Bellaire and Valley Junction Railway | | W&LE | 1890 | 1901 | Adena Railroad |
| Bellaire, Zanesville and Cincinnati Railway | | PRR | 1882 | 1902 | Ohio River and Western Railway |
| Bellefontaine Railway | | NYC | 1864 | 1868 | Cleveland, Columbus, Cincinnati and Indianapolis Railway |
| Bellefontaine and Indiana Railroad | | NYC | 1848 | 1864 | Bellefontaine Railway |
| Belmont Central Railroad | | B&O | 1907 | 1914 | Cleveland, Lorain and Wheeling Railway |
| Belpre and Cincinnati Railroad | | B&O | 1845 | 1851 | Marietta and Cincinnati Railroad |
| Bowling Green Railroad | | B&O | 1874 | 1943 | Toledo and Cincinnati Railroad |
| Butler and Detroit Railroad | | WAB | 1880 | 1881 | Detroit, Butler and St. Louis Railroad |
| Canal Belt Railroad | | ERIE | | | |
| Canton and Waynesburgh Railroad | | W&LE | 1884 | 1888 | Waynesburg and Canton Railroad |
| Canton and Wooster Railroad | | | | | |
| Carroll County Railroad | | W&LE | 1850 | 1866 | Carrollton and Oneida Railroad |
| Carrollton and Oneida Railroad | | W&LE | 1866 | 1873 | Ohio and Toledo Railroad |
| Celina, Van Wert and State Line Extension of the Columbus and North-Western Railway | | NYC | 1878 | 1881 | Cincinnati, Van Wert and Michigan Railroad |
| Central Columbiana and Pennsylvania Railway | CQPA | | 2001 | 2004 | Ohio and Pennsylvania Railroad |
| Central Ohio Railroad | | B&O | 1847 | 1915 | Baltimore and Ohio Railroad |
| Central Union Depot and Railway Company of Cincinnati | | B&O/NYC | 1884 | 1935 | N/A |
| Central Valley Railway | | W&LE | 1901 | 1916 | Wheeling and Lake Erie Railroad |
| Chagrin Falls and Lake Erie Railroad | | W&LE | 1901 | 1916 | Wheeling and Lake Erie Railway |
| Chagrin Falls and Southern Railroad | | W&LE | 1880 | 1890 | Cleveland, Chagrin Falls and Northern Railroad |
| Chesapeake and Hocking Railway | | C&O | 1926 | 1930 | Chesapeake and Ohio Railway |
| Chesapeake and Ohio Railway | C&O, CO | C&O | 1889 | 1987 | CSX Transportation |
| Chesapeake and Ohio Northern Railway | | C&O | 1914 | 1930 | Chesapeake and Ohio Railway |
| Chesapeake and Ohio Railway of Indiana | | C&O | 1910 | 1934 | Chesapeake and Ohio Railway |
| Chicago and Atlantic Railway | | ERIE | 1873 | 1890 | Chicago and Erie Railroad |
| Chicago, Cincinnati and Louisville Railroad | | C&O | 1903 | 1910 | Chesapeake and Ohio Railway of Indiana |
| Chicago and Erie Railroad | | ERIE | 1890 | 1941 | Erie Railroad |
| Chicago and Canada Southern Railway | | NYC | 1871 | 1888 | Detroit and Chicago Railroad |
| Chicago, St. Louis and Pittsburgh Railroad | | PRR | 1883 | 1890 | Pittsburgh, Cincinnati, Chicago and St. Louis Railway |
| Chicago, Zanesville and Atlantic Railway | | B&O | 1885 | 1886 | Zanesville and Ohio River Railway |
| Cincinnati and Baltimore Railway | | B&O | 1868 | 1894 | Cincinnati, Washington and Baltimore Railroad |
| Cincinnati, Batavia and Williamsburg Railroad | | N&W | 1876 | 1876 | Cincinnati and Eastern Railway |
| Cincinnati, Columbus and Hocking Valley Railway | | DT&I | 1881 | 1886 | Ohio Southern Railroad |
| Cincinnati Connecting Belt Railroad | | N&W | 1899 | 1901 | Cincinnati, Portsmouth and Virginia Railroad |
| Cincinnati and Dayton Railway | | B&O | 1887 | 1943 | Toledo and Cincinnati Railroad |
| Cincinnati, Dayton and Chicago Railroad | | B&O | 1891 | 1895 | Cincinnati, Hamilton and Dayton Railway |
| Cincinnati, Dayton and Ironton Railroad | | B&O | 1891 | 1895 | Cincinnati, Hamilton and Dayton Railway |
| Cincinnati and Eastern Railway | | N&W | 1876 | 1887 | Ohio and North Western Railroad |
| Cincinnati, Findlay and Fort Wayne Railway | | | 1903 | 1919 | N/A |
| Cincinnati, Georgetown and Portsmouth Railroad | CG&P | | 1873 | | |
| Cincinnati and Hamilton Railroad | | B&O | 1846 | 1847 | Cincinnati, Hamilton and Dayton Railroad |
| Cincinnati, Hamilton and Dayton Railroad | | B&O | 1847 | 1895 | Cincinnati, Hamilton and Dayton Railway |
| Cincinnati, Hamilton and Dayton Railway | | B&O | 1895 | 1917 | Toledo and Cincinnati Railroad |
| Cincinnati, Hamilton and Indianapolis Railroad | | B&O | 1872 | 1902 | Cincinnati, Indianapolis and Western Railway |
| Cincinnati and Indiana Railroad | | NYC | 1861 | 1880 | Cincinnati, Indianapolis, St. Louis and Chicago Railway |
| Cincinnati and Indiana Western Railroad | | C&O | 1902 | 1903 | Chicago, Cincinnati and Louisville Railroad |
| Cincinnati, Indianapolis, St. Louis and Chicago Railway | | NYC | 1880 | 1889 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Cincinnati, Indianapolis and Western Railroad | CIWN | B&O | 1915 | 1990 | CSX Transportation |
| Cincinnati, Indianapolis and Western Railway | | B&O | 1902 | 1915 | Cincinnati, Indianapolis and Western Railroad |
| Cincinnati Inter-Terminal Railroad | | C&O | 1902 | | Still exists as a nonoperating subsidiary of CSX Transportation |
| Cincinnati, Jackson and Mackinaw Railroad | | NYC | 1886 | 1892 | Cincinnati, Jackson and Mackinaw Railway |
| Cincinnati, Jackson and Mackinaw Railway | | NYC | 1892 | 1897 | Cincinnati Northern Railroad |
| Cincinnati, Lebanon and Northern Railway | | PRR | 1885 | 1926 | Pennsylvania, Ohio and Detroit Railroad |
| Cincinnati, Lebanon and Xenia Railroad | | PRR | 1850 | 1869 | Miami Valley Narrow Gauge Railway |
| Cincinnati and Michigan Railroad | | NYC | 1891 | 1892 | Cincinnati, Jackson and Mackinaw Railway |
| Cincinnati and Muskingum Valley Railroad | | PRR | 1898 | 1911 | Cleveland, Akron and Cincinnati Railway |
| Cincinnati and Muskingum Valley Railway | | PRR | 1870 | 1898 | Cincinnati and Muskingum Valley Railroad |
| Cincinnati Northern Railroad | CNOR | NYC | 1894 | 1938 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Cincinnati Northern Railway | | PRR | 1880 | 1883 | Toledo, Cincinnati and St. Louis Railroad |
| Cincinnati Northwestern Railway | | | | | |
| Cincinnati and Portsmouth Railroad | | | | | |
| Cincinnati, Portsmouth and Parkersburg Railway | | B&O | 1899 | 1899 | Baltimore and Ohio Southwestern Railroad |
| Cincinnati, Portsmouth and Virginia Railroad | | N&W | 1891 | 1901 | Norfolk and Western Railway |
| Cincinnati Railway Tunnel Company | | PRR | 1872 | 1896 | Cincinnati, Lebanon and Northern Railway |
| Cincinnati and Richmond Railroad | | PRR | 1881 | 1890 | Pittsburgh, Cincinnati, Chicago and St. Louis Railway |
| Cincinnati, Richmond and Chicago Railroad | | PRR | 1866 | 1890 | Cincinnati and Richmond Railroad |
| Cincinnati, Sandusky and Cleveland Railroad | | NYC | 1868 | 1938 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Cincinnati Southern Railway | | SOU | 1869 | | | Still exists as a lessor of Norfolk Southern Railway operating subsidiary Cincinnati, New Orleans and Texas Pacific Railway |
| Cincinnati and Springfield Railway | | NYC | 1870 | 1912 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Cincinnati Terminal Railway | CTER | | 1994 | 1997 | Indiana and Ohio Railway |
| Cincinnati, Van Wert and Michigan Railroad | | NYC | 1881 | 1886 | Cincinnati, Jackson and Mackinaw Railroad |
| Cincinnati, Washington and Baltimore Railroad | | B&O | 1883 | 1889 | Baltimore and Ohio Southwestern Railroad |
| Cincinnati and Westwood Railroad | | | | | |
| Cincinnati, Wheeling and New York Railroad | | B&O | 1883 | 1891 | Eastern Ohio Railroad |
| Cincinnati, Wilmington and Zanesville Railroad | | PRR | 1851 | 1863 | Cincinnati and Zanesville Railroad |
| Cincinnati and Zanesville Railroad | | PRR | 1864 | 1869 | Cincinnati and Muskingum Valley Railway |
| Cleveland, Akron and Cincinnati Railway | | PRR | 1911 | 1926 | Pennsylvania, Ohio and Detroit Railroad |
| Cleveland, Akron and Columbus Railroad | | PRR | 1881 | 1882 | Cleveland, Akron and Columbus Railway |
| Cleveland, Akron and Columbus Railway | | PRR | 1885 | 1911 | Cleveland, Akron and Cincinnati Railway |
| Cleveland, Barberton and Western Railroad | | ACY/ B&O/ ERIE/ PRR | 1899 | 1902 | Akron and Barberton Belt Railroad |
| Cleveland Belt Line Railroad | | W&LE | 1890 | 1891 | Cleveland Belt and Terminal Railroad |
| Cleveland Belt and Terminal Railroad | | W&LE | 1891 | 1899 | Wheeling and Lake Erie Railroad |
| Cleveland and Canton Railroad | | W&LE | 1885 | 1892 | Cleveland, Canton and Southern Railroad |
| Cleveland, Canton, Coshocton and Straitsville Railway | | W&LE | 1877 | 1881 | Connotton Valley and Straitsville Railroad |
| Cleveland, Canton and Southern Railroad | | W&LE | 1890 | 1899 | Chagrin Falls and Lake Erie Railroad, Wheeling and Lake Erie Railroad |
| Cleveland, Chagrin Falls and Northern Railroad | | W&LE | 1888 | 1891 | Cleveland and Canton Railroad |
| Cleveland, Cincinnati, Chicago and St. Louis Railway | | NYC | 1889 | 1976 | Consolidated Rail Corporation |
| Cleveland, Columbus and Cincinnati Railroad | | NYC | 1836 | 1868 | Cleveland, Columbus, Cincinnati and Indianapolis Railway |
| Cleveland, Columbus, Cincinnati and Indianapolis Railway | | NYC | 1868 | 1889 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Cleveland, Delphos and St. Louis Railroad | | ACY | 1881 | 1885 | Cleveland and Western Railroad |
| Cleveland, Fort Wayne and Chicago Railroad | | NKP | 1865 | 1879 | Ohio Railway |
| Cleveland, Lorain and Wheeling Railroad | | B&O | 1883 | 1893 | Cleveland, Lorain and Wheeling Railway |
| Cleveland, Lorain and Wheeling Railway | | B&O | 1893 | 1915 | Baltimore and Ohio Railroad |
| Cleveland and Mahoning Railroad | | ERIE | 1848 | 1872 | Cleveland and Mahoning Valley Railroad |
| Cleveland and Mahoning Railway | | PRR | 1886 | 1911 | Toledo, Columbus and Ohio River Railroad |
| Cleveland and Mahoning Valley Railroad | | ERIE | 1872 | 1941 | Erie Railroad |
| Cleveland and Marietta Railroad | | PRR | 1879 | 1886 | Cleveland and Marietta Railway |
| Cleveland and Marietta Railway | | PRR | 1886 | 1911 | Toledo, Columbus and Ohio River Railroad |
| Cleveland, Medina and Tuscarawas Railroad | | B&O | 1853 | 1870 | Lake Shore and Tuscarawas Valley Railway |
| Cleveland, Mount Vernon and Delaware Railroad | | PRR | 1869 | 1881 | Cleveland, Akron and Columbus Railroad |
| Cleveland and New Castle Railway | | PRR | 1898 | 1899 | Youngstown and Ravenna Railroad |
| Cleveland, Painesville and Ashtabula Railroad | | NYC | 1848 | 1868 | Lake Shore Railway |
| Cleveland and Pittsburgh Railroad | | PRR | 1836 | 1976 | Consolidated Rail Corporation |
| Cleveland Short Line Railway | | NYC | 1902 | 1915 | New York Central Railroad |
| Cleveland and Southwestern Railway | | B&O | 1887 | 1893 | Cleveland, Lorain and Wheeling Railway |
| Cleveland and State Line Railroad | | NKP | 1887 | 1887 | New York, Chicago and St. Louis Railroad |
| Cleveland Terminal and Valley Railway | | B&O | 1895 | 1915 | Baltimore and Ohio Railroad |
| Cleveland and Toledo Railroad | | NYC | 1853 | 1869 | Lake Shore Railway |
| Cleveland, Toledo and Lakeside Railway | | | 1885 | 1886 | Lakeside and Marblehead Railroad |
| Cleveland, Tuscarawas Valley and Wheeling Railway | | B&O | 1875 | 1883 | Cleveland, Lorain and Wheeling Railroad |
| Cleveland Union Terminals Company | | | | | |
| Cleveland and Western Railroad | | ACY | 1884 | 1890 | Pittsburgh, Akron and Western Railroad |
| Cleveland and Wheeling Railroad | | NYC | 1887 | 1895 | Wheeling and Cleveland Railroad |
| Cleveland, Wooster and Muskingum Valley Railroad | | B&O | 1890 | 1915 | Baltimore and Ohio Railroad |
| Cleveland, Youngstown and Pittsburgh Railroad | | NYC | 1881 | 1882 | Cleveland, Youngstown and Pittsburgh Railway |
| Cleveland, Youngstown and Pittsburgh Railway | | NYC | 1882 | 1886 | Lake Erie, Alliance and Southern Railway |
| Cleveland, Zanesville and Cincinnati Railroad | | PRR | 1853 | 1864 | Pittsburgh, Fort Wayne and Chicago Railway |
| College Hill Railroad | | | | | |
| Columbus, Chicago and Indiana Central Railway | | PRR | 1868 | 1883 | Chicago, St. Louis and Pittsburgh Railroad |
| Columbus and Cincinnati Railroad | | B&O | 1882 | 1882 | Columbus and Cincinnati Midland Railroad |
| Columbus and Cincinnati Midland Railroad | | B&O | 1882 | 1915 | Baltimore and Ohio Railroad |
| Columbus Connecting and Terminal Railroad | | N&W | 1892 | 1913 | Norfolk and Western Railway |
| Columbus and Eastern Railroad | | NYC | 1882 | 1890 | Columbus, Shawnee and Hocking Railway |
| Columbus, Findlay and Northern Railroad | | B&O | 1887 | 1943 | Toledo and Cincinnati Railroad |
| Columbus and Gallipolis Railway | | C&O | 1876 | 1878 | Ohio and West Virginia Railway |
| Columbus and Hocking Valley Railroad | | C&O | 1867 | 1881 | Columbus, Hocking Valley and Toledo Railway |
| Columbus, Hocking Valley and Toledo Railway | | C&O | 1881 | 1899 | Hocking Valley Railway |
| Columbus and Indiana Central Railway | | PRR | 1867 | 1868 | Columbus, Chicago and Indiana Central Railway |
| Columbus and Indianapolis Railroad | | PRR | 1863 | 1864 | Columbus and Indianapolis Central Railway |
| Columbus and Indianapolis Central Railway | | PRR | 1864 | 1867 | Columbus and Indiana Central Railway |
| Columbus and Lake Erie Railroad | | B&O | 1845 | 1854 | Sandusky, Mansfield and Newark Railroad |
| Columbus, Lancaster and Wellston Railway | | | | | |
| Columbus and Maysville Railroad | | N&W | 1881 | 1901 | Cincinnati, Portsmouth and Virginia Railroad |
| Columbus and Maysville Railroad, Southern Division | | N&W | 1877 | 1881 | Columbus and Maysville Railroad |
| Columbus Northwestern Railway | | DT&I, NYC | 1897 | 1898 | Detroit and Lima Northern Railway |
| Columbus, Piqua and Indiana Railroad | | PRR | 1849 | 1863 | Columbus and Indianapolis Railroad |
| Columbus, Sandusky and Hocking Railroad | | NYC, PRR | 1895 | 1902 | Toledo, Walhonding Valley and Ohio Railroad, Zanesville and Western Railway |
| Columbus, Sandusky and Hocking Railway | | NYC, PRR | 1893 | 1895 | Columbus, Sandusky and Hocking Railroad |
| Columbus, Shawnee and Hocking Railway | | NYC | 1889 | 1893 | Columbus, Sandusky and Hocking Railway |
| Columbus and Southern Railway | | | | | |
| Columbus, Springfield and Cincinnati Railroad | | NYC | 1869 | 1912 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Columbus and Sunday Creek Valley Railroad | | NYC | 1878 | 1879 | Ohio Central Railroad |
| Columbus Terminal and Transfer Railroad | | N&W | 1893 | 1905 | Norfolk and Western Railway |
| Columbus, Tiffin and Toledo Railroad | | PRR | 1867 | 1870 | Baltimore and Ohio, Toledo and Michigan Railroad |
| Columbus and Toledo Railroad | | C&O | 1872 | 1881 | Columbus, Hocking Valley and Toledo Railway |
| Columbus, Washington and Cincinnati Railroad | | DT&I | 1877 | 1879 | Cincinnati, Columbus and Hocking Valley Railway |
| Columbus, Wellston and Southern Railroad | | | 1899 | | |
| Columbus and Xenia Railroad | | PRR | 1844 | 1943 | Little Miami Railroad |
| Conneaut Terminal Railroad | | B&LE | 1892 | 1893 | Pittsburgh, Shenango and Lake Erie Railroad |
| Connecting Railway | | PRR | 1956 | 1976 | Consolidated Rail Corporation |
| Connotton Northern Railway | | W&LE | 1880 | 1880 | Connotton Valley Railway |
| Connotton Valley Railroad | | W&LE | 1879 | 1880 | Connotton Valley Railway |
| Connotton Valley Railway | CVRI | | 2002 | 2004 | Cleveland Commercial Railroad |
| Connotton Valley Railway | | W&LE | 1880 | 1885 | Cleveland and Canton Railroad |
| Connotton Valley and Straitsville Railroad | | W&LE | 1881 | 1882 | Connotton Valley Railway |
| Consolidated Rail Corporation | CR | | 1976 | 1999 | CSX Transportation, Norfolk Southern Railway |
| Coshocton, Otsego and Eastern Railroad | | W&LE | 1909 | 1917 | Wheeling and Lake Erie Railway |
| Coshocton and Southern Railroad | | W&LE | 1885 | 1891 | Cleveland, Canton and Southern Railroad |
| Coshocton, Wooster and Cleveland Railroad | | B&O | 1851 | 1853 | Cleveland, Medina and Tuscarawas Railroad |
| Covington and Cincinnati Elevated Railroad and Transfer and Bridge Company | | C&O | 1886 | 1985 | Chesapeake and Ohio Railway |
| Culver and Port Clinton Railroad | | | | | |
| Cuyahoga Valley Railway | CUVA | | 1905 | 2002 | Cleveland Works Railway |
| Dayton and Chicago Railway | | B&O | 1886 | 1887 | Dayton, Fort Wayne and Chicago Railway |
| Dayton and Cincinnati Railroad | | PRR | 1849 | 1872 | Cincinnati Railway Tunnel Company |
| Dayton and Cincinnati Terminal Railroad | | NYC | 1894 | 1894 | Cincinnati Northern Railroad |
| Dayton, Covington and Toledo Railroad | | B&O | 1877 | 1880 | Toledo, Delphos and Burlington Railroad |
| Dayton, Fort Wayne and Chicago Railway | | B&O | 1887 | 1891 | Cincinnati, Dayton and Chicago Railroad, Cincinnati, Dayton and Ironton Railroad |
| Dayton, Hocking Valley and Eastern Railway | | C&O | 1890 | 1900 | Hocking Valley Railway |
| Dayton and Ironton Railroad | | B&O | 1884 | 1887 | Dayton, Fort Wayne and Chicago Railway |
| Dayton, Lebanon and Cincinnati Railroad | | PRR | 1889 | 1907 | Dayton, Lebanon and Cincinnati Railroad and Terminal Company |
| Dayton, Lebanon and Cincinnati Railroad and Terminal Company | | PRR | 1907 | 1915 | Cincinnati, Lebanon and Northern Railway |
| Dayton, Lebanon and Deerfield Railroad | | PRR | 1847 | 1848 | Dayton, Springboro, Lebanon and Cincinnati Railroad |
| Dayton and Michigan Railroad | | B&O | 1851 | | | Still exists as a nonoperating subsidiary of CSX Transportation |
| Dayton Northern Railway | | DT&I | 1895 | 1898 | Detroit and Lima Northern Railway |
| Dayton and Northern Railway | | B&O | 1886 | 1886 | Dayton and Chicago Railway |
| Dayton and South Eastern Railroad | | B&O | 1871 | 1881 | Toledo, Delphos and Burlington Railroad |
| Dayton, Springboro, Lebanon and Cincinnati Railroad | | PRR | 1848 | 1849 | Dayton and Cincinnati Railroad |
| Dayton and Toledo Railroad | | B&O | 1885 | 1886 | Dayton and Northern Railway |
| Dayton, Toledo and Chicago Railway | | | | | |
| Dayton Union Railway | | B&O/ NYC/ PRR | 1892 | 1976 | Consolidated Rail Corporation |
| Dayton and Union Railroad | | B&O | 1863 | 1989 | CSX Transportation |
| Dayton and Western Railroad | | PRR | 1846 | 1943 | Little Miami Railroad |
| Dayton, Xenia and Belpre Railroad | | PRR | 1851 | 1865 | Columbus and Xenia Railroad, Little Miami Railroad |
| Delphos and Kokomo Railroad | | NKP | 1877 | 1879 | Toledo, Delphos and Burlington Railroad |
| Detroit, Butler and St. Louis Railroad | | WAB | 1881 | 1881 | Wabash, St. Louis and Pacific Railway |
| Detroit and Chicago Railroad | | NYC | 1888 | 1914 | New York Central Railroad |
| Detroit and Lima Northern Railway | | DT&I, NYC | 1897 | 1901 | Detroit Southern Railroad, Toledo and Ohio Central Railway |
| Detroit Southern Railroad | | DT&I | 1901 | 1905 | Detroit, Toledo and Ironton Railway |
| Detroit and State Line Wabash Railroad | | WAB | 1889 | 1889 | Wabash Railroad |
| Detroit, Toledo and Ironton Railroad | DT&I, DTI | DT&I | 1914 | 1983 | Grand Trunk Western Railroad |
| Detroit, Toledo and Ironton Railway | | DT&I | 1905 | 1913 | Detroit, Toledo and Ironton Railroad |
| Detroit and Toledo Shore Line Railroad | D&TS, DTS | CN/ NKP | 1899 | 1981 | Grand Trunk Western Railroad |
| Eastern Ohio Railroad | | B&O | 1891 | 1915 | Baltimore and Ohio Railroad |
| Eastern Ohio Railroad | | B&O | 1871 | 1882 | Wheeling and Cincinnati Mineral Railway |
| Eaton and Hamilton Railroad | | PRR | 1847 | 1866 | Cincinnati, Richmond and Chicago Railroad |
| Elyria and Black River Railway | | B&O | 1871 | 1872 | Lake Shore and Tuscarawas Valley Railway |
| Erie Railroad | ERIE | ERIE | 1895 | 1960 | Erie–Lackawanna Railroad |
| Erie and Kalamazoo Railroad | | NYC | 1833 | 1976 | Consolidated Rail Corporation |
| Erie–Lackawanna Railroad | EL | | 1960 | 1968 | Erie Lackawanna Railway |
| Erie Lackawanna Railway | EL | | 1968 | 1976 | Consolidated Rail Corporation |
| Euclid Railroad | | | 1883 | 1967 | N/A |
| Fairport, Painesville and Eastern Railroad | FP&E, FPE | N&W | 1910 | 1984 | Norfolk and Western Railway |
| Federal Valley Railroad | | NYC | 1918 | 1952 | New York Central Railroad |
| Felicity and Bethel Railroad | | | | | |
| Findlay Belt Railway | | NYC | 1887 | 1932 | N/A |
| Findlay, Fort Wayne and Western Railroad | | | 1890 | 1894 | Ohio Railway |
| Findlay, Fort Wayne and Western Railway | | | 1894 | 1903 | Cincinnati, Findlay and Fort Wayne Railway |
| Findlay and Western Railroad | | | 1890 | 1890 | Findlay, Fort Wayne and Western Railroad |
| Flint and Pere Marquette Railroad | | PM | 1897 | 1899 | Pere Marquette Railroad |
| Franklin and Ohio River Railroad | | | | | |
| Franklin and Warren Railroad | | ERIE | 1851 | 1853 | Atlantic and Great Western Railroad |
| Fremont and Indiana Railroad | | NKP | 1853 | 1861 | Fremont, Lima and Union Railroad |
| Fremont, Lima and Union Railroad | | NKP | 1862 | 1865 | Lake Erie and Louisville Railroad |
| Fremont, Lima and Union Railway | | NKP | 1871 | 1872 | Lake Erie and Louisville Railway |
| Gallipolis, McArthur and Columbus Railroad | | C&O | 1870 | 1877 | Columbus and Gallipolis Railway |
| Grafton and Brunswick Railroad | | | | | |
| Great Miami and Scioto Railway | GMRY | | 1994 | 2004 | U S Rail Corporation |
| Greenville and Miami Railroad | | B&O | 1846 | 1862 | Dayton and Union Railroad |
| Hamilton Belt Railway | | B&O | 1896 | 1944 | Baltimore and Ohio Railroad |
| Harrison Branch Company | | NYC | 1864 | 1871 | Harrison Branch Railroad |
| Harrison Branch Railroad | | NYC | 1871 | 1912 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Harrison, Jefferson and Belmont Railway | | W&LE | 1887 | 1888 | Jefferson and Columbiana Railway |
| Hillsboro Railroad | | N&W | 1895 | 1902 | Norfolk and Western Railway |
| Hillsborough and Cincinnati Railroad | | B&O | 1846 | 1860 | Marietta and Cincinnati Railroad |
| Hillsboro Short Line Railway | | N&W | 1879 | 1902 | Norfolk and Western Railway |
| Hillsdale County Railroad | | | 1986 | 1992 | Indiana Northeastern Railroad |
| Hocking Valley Railway | HV | C&O | 1899 | 1930 | Chesapeake and Ohio Railway |
| Holliday's Cove Railroad | | PRR | 1860 | 1868 | Pittsburgh, Cincinnati and St. Louis Railway |
| Home Avenue Railroad | | B&O | 1871 | | | Still exists as a nonoperating subsidiary of CSX Transportation |
| Huron and Oxford Railroad | | B&O | 1846 | 1854 | Sandusky, Mansfield and Newark Railroad |
| Indiana, Bloomington and Western Railway | | NYC | 1881 | 1887 | Springfield and Western Railway |
| Indiana Hi-Rail Corporation | IHRC | | 1980 | 1997 | Delphos Terminal Company, Maumee and Western Railroad |
| Indiana and Ohio Railroad | INOH | | 1979 | 1997 | Indiana and Ohio Railway |
| Indiana and Ohio Central Railroad | IOCR | | 1987 | 2005 | Indiana and Ohio Railway |
| Indiana and Ohio Eastern Railroad | | | 1987 | 1994 | Great Miami and Scioto Railway |
| Indianapolis and Cincinnati Railroad | | NYC | 1866 | 1867 | Indianapolis, Cincinnati and La Fayette Railway |
| Indianapolis, Cincinnati and La Fayette Railroad | | NYC | 1873 | 1880 | Cincinnati, Indianapolis, St. Louis and Chicago Railway |
| Indianapolis, Cincinnati and La Fayette Railway | | NYC | 1867 | 1873 | Indianapolis, Cincinnati and La Fayette Railroad |
| Industrial Railroad | | ERIE/ PRR | 1903 | 1910 | Lorain, Ashland and Southern Railroad |
| Iron Railroad | | DT&I | 1849 | 1881 | Toledo, Delphos and Burlington Railroad |
| Iron Railway | | DT&I | 1884 | 1902 | Detroit Southern Railroad |
| Island Creek and Richmond Mineral Railroad | | NYC | 1877 | 1881 | Steubenville, Canton and Cleveland Railway |
| Ivorydale and Mill Creek Valley Railway | | | | | |
| Jefferson and Columbiana Railway | | W&LE | 1888 | 1888 | Wheeling and Lake Erie Railway |
| Junction Railroad | | B&O | 1849 | 1878 | Cincinnati, Hamilton and Indianapolis Railroad |
| Junction Railroad | | NYC | 1846 | 1853 | Cleveland and Toledo Railroad |
| Junction Railway | | NYC | 1872 | 1872 | Toledo, Canada Southern and Detroit Railway |
| Kanawha and Michigan Railway | K&M | NYC | 1890 | 1938 | Toledo and Ohio Central Railway |
| Kanawha and Ohio Railway | | NYC | 1886 | 1890 | Kanawha and Michigan Railway |
| Lake Erie, Alliance and Southern Railway | | NYC | 1887 | 1893 | Alliance and Northern Railroad, Ohio River and Lake Erie Railroad |
| Lake Erie, Alliance and Wheeling Railroad | | NYC | 1901 | 1952 | New York Central Railroad |
| Lake Erie, Alliance and Wheeling Railroad | | NYC | 1874 | 1878 | Alliance and Lake Erie Railroad |
| Lake Erie and Eastern Railroad | LEE | PLE | 1904 | 1984 | Pittsburgh and Lake Erie Railroad |
| Lake Erie and Louisville Railroad | | NKP | 1877 | 1879 | Lake Erie and Western Railway |
| Lake Erie and Louisville Railroad | | NKP | 1865 | 1871 | Fremont, Lima and Union Railway |
| Lake Erie and Louisville Railway | | NKP | 1872 | 1877 | Lake Erie and Louisville Railroad |
| Lake Erie and Pittsburgh Railway | | NYC/ PRR | 1903 | 1970 | Penn Central Transportation Company |
| Lake Erie and Western Railroad | | NKP | 1887 | 1923 | New York, Chicago and St. Louis Railroad |
| Lake Erie and Western Railway | | NKP | 1879 | 1886 | Lake Erie and Western Railroad |
| Lake Erie, Wooster and Muskingum Valley Railroad | | B&O | 1881 | 1891 | Cleveland, Wooster and Muskingum Valley Railroad |
| Lake Erie, Youngstown and Southern Railroad | | PLE | 1902 | 1912 | Lake Erie and Eastern Railroad |
| Lake and River Railway | | ACY, ERIE/ PRR | 1903 | 1907 | Ashland and Western Railroad, Akron, Canton and Youngstown Railway |
| Lake Shore Railway | | NYC | 1868 | 1869 | Lake Shore and Michigan Southern Railway |
| Lake Shore and Michigan Southern Railway | | NYC | 1869 | 1914 | New York Central Railroad |
| Lake Shore and Tuscarawas Valley Railway | | B&O | 1870 | 1875 | Cleveland, Tuscarawas Valley and Wheeling Railway |
| Lake View and Collamer Railroad | | | 1875 | 1882 | New York, Chicago and St. Louis Railroad | Operated as Cleveland, Painesville and Ashtabula Railroad from 1879 to 1882 |
| Lakeside and Marblehead Railroad | | | 1886 | 1964 | N/A |
| Lancaster and Hamden Railway | | | | | |
| Lawrence Railroad | | PRR | 1865 | 1887 | Youngstown, Lawrence and Pittsburgh Railroad |
| Lawrence Railroad and Transportation Company | | PRR | 1864 | 1865 | Lawrence Railroad |
| Liberty and Vienna Railroad | | ERIE | 1868 | 1872 | Cleveland and Mahoning Valley Railway |
| Lima Belt Railway | | B&O | 1900 | 1944 | Baltimore and Ohio Railroad |
| Lima Northern Railway | | DT&I | 1895 | 1897 | Detroit and Lima Northern Railway |
| Little Miami Railroad | | PRR | 1836 | 1976 | Consolidated Rail Corporation |
| Lorain and Ashland Railroad | | ERIE/ PRR | 1905 | 1910 | Lorain, Ashland and Southern Railroad |
| Lorain, Ashland and Southern Railroad | LA&S | ERIE/ PRR | 1910 | 1925 | N/A |
| Lorain and Southern Railroad | | | 1903 | 1952 | N/A |
| Lorain and West Virginia Railway | LAWV | W&LE | 1906 | 1983 | N/A |
| Louisville, Cincinnati and Dayton Railway | | B&O | 1886 | 1888 | Cincinnati and Dayton Railway |
| Louisville, Cincinnati and Lexington Railroad | | L&N | 1872 | 1877 | Louisville, Cincinnati and Lexington Railway |
| Louisville, Cincinnati and Lexington Railway | | L&N | 1877 | 1881 | Louisville and Nashville Railroad |
| Louisville and Nashville Railroad | L&N, LN | L&N | 1881 | 1983 | Seaboard System Railroad |
| Mad River and Lake Erie Railroad | | NYC | 1832 | 1858 | Sandusky, Dayton and Cincinnati Railroad |
| Mahoning Coal Railroad | | NYC | 1871 | 1976 | Consolidated Rail Corporation |
| Mahoning and Shenango Valley Railway | | NYC | 1886 | 1976 | Consolidated Rail Corporation |
| Mahoning State Line Railroad | | PLE | 1891 | | | Still exists as a nonoperating subsidiary of CSX Transportation |
| Mahoning Valley Western Railway | | B&O | 1902 | 1915 | Baltimore and Ohio Railroad |
| Mansfield, Coldwater and Lake Michigan Railroad | | PRR | 1871 | 1877 | Northwestern Ohio Railway |
| Mansfield, Coldwater and Lake Michigan Railway | | PRR | 1870 | 1871 | Mansfield, Coldwater and Lake Michigan Railroad |
| Mansfield and New Haven Railroad | | B&O | 1836 | 1843 | Mansfield and Sandusky City Railroad |
| Mansfield and Sandusky City Railroad | | B&O | 1843 | 1854 | Sandusky, Mansfield and Newark Railroad |
| Manufacturers Railway | | PRR | 1894 | 1926 | Pennsylvania, Ohio and Detroit Railroad |
| Marietta Railway | | B&O | 1896 | 1900 | Baltimore and Ohio Southwestern Railroad |
| Marietta and Cincinnati Railroad | | B&O | 1851 | 1882 | Cincinnati, Washington and Baltimore Railroad |
| Marietta, Columbus and Cleveland Railroad | | | 1900 | 1916 | Federal Valley Railroad, Marietta and Vincent Railroad |
| Marietta, Columbus and Northern Railroad | | | | | |
| Marietta, Hocking and Northern Railway | | | | | |
| Marietta and Pittsburgh Railroad | | PRR | 1868 | 1873 | Marietta, Pittsburg and Cleveland Railway |
| Marietta, Pittsburg and Cleveland Railway | | PRR | 1873 | 1877 | Cleveland and Marietta Railroad |
| Marietta and Vincent Railroad | | | 1900 | | |
| Martins Ferry Terminal Railroad | | PRR | 1888 | 1892 | Wheeling Bridge and Terminal Railway |
| Massillon Railroad | | W&LE | 1892 | 1904 | Wheeling and Lake Erie Railroad |
| Massillon Belt Railway | | | 1909 | 1929 | N/A |
| Massillon and Cleveland Railroad | | PRR | 1868 | 1928 | Pittsburgh, Fort Wayne and Chicago Railway |
| Massillon and Coshocton Railway | | W&LE | 1874 | 1877 | Cleveland, Canton, Coshocton and Straitsville Railway |
| McComb, Deshler and Toledo Railroad | | B&O | 1879 | 1887 | Columbus, Findlay and Northern Railroad |
| Miami Valley Railway | | PRR | 1876 | 1880 | Cincinnati Northern Railway |
| Miami Valley Narrow Gauge Railway | | PRR | 1874 | 1876 | Miami Valley Railway |
| Michigan Central Railroad | MC | NYC | 1883 | 1976 | Consolidated Rail Corporation |
| Michigan Interstate Railway | | | 1977 | 1988 | Ann Arbor Railroad |
| Michigan and Ohio Railroad | | NYC | 1883 | 1887 | Cincinnati, Jackson and Mackinaw Railroad |
| Michigan Southern and Northern Indiana Railroad | | NYC | 1855 | 1869 | Lake Shore and Michigan Southern Railway |
| Middleport and Northeastern Railway | | NYC | 1913 | 1938 | Toledo and Ohio Central Railway |
| Middletown and Cincinnati Railroad | | PRR | 1894 | 1902 | Cincinnati, Lebanon and Northern Railway |
| Middletown and Cincinnati Railway | | PRR | 1890 | 1894 | Middletown and Cincinnati Railroad |
| Middletown and State Line Railroad | | B&O | 1886 | 1886 | Louisville, Cincinnati and Dayton Railway |
| Midway Railroad | MID | | 1963 | 1973 | N/A |
| Millersburgh, Jeromeville and Greenwich Railroad | | ERIE/ PRR | 1894 | 1897 | Ashland and Wooster Railway |
| Mineral Railroad | | C&O | 1864 | 1867 | Columbus and Hocking Valley Railroad |
| Monroe and Toledo Railway | | PM | 1893 | 1897 | Flint and Pere Marquette Railroad |
| Monroeville and Sandusky City Railroad | | B&O | 1835 | 1843 | Sandusky, Mansfield and Newark Railroad |
| Montpelier and Chicago Railroad | | WAB | 1889 | 1891 | Wabash Railroad |
| Morgan Run Railway | | | | | |
| Mount Gilead Short Line Railway | | NYC | 1879 | 1966 | N/A |
| Moxahala Valley Railway | MOXV | | 1983 | 1986 | Ohio Southern Railroad |
| Muskingum County Railway | | PRR | 1881 | 1893 | Bellaire, Zanesville and Cincinnati Railway |
| New Castle and Ohio River Railway | | | | | |
| New Lisbon Railway | | ERIE | 1864 | 1869 | Niles and New Lisbon Railway |
| New York Central Railroad | NYC | NYC | 1914 | 1968 | Penn Central Transportation Company |
| New York and Chicago Railway of Ohio | | NKP | 1881 | 1881 | New York, Chicago and St. Louis Railway |
| New York, Chicago and St. Louis Railroad | NKP | NKP | 1887 | 1964 | Norfolk and Western Railway |
| New York, Chicago and St. Louis Railway | | NKP | 1881 | 1887 | Cleveland and State Line Railroad |
| New York, Fort Wayne and Chicago Railroad | | NKP | 1880 | 1881 | New York, Chicago and St. Louis Railway |
| New York, Lake Erie and Western Railroad | | ERIE | 1883 | 1895 | Erie Railroad |
| New York, Mahoning and Western Railroad | | | 1887 | 1889 | American Midland Railway |
| New York, Pennsylvania and Ohio Railroad | | ERIE | 1880 | 1896 | Nypano Railroad |
| New York, Pittsburgh and Chicago Railway | | PLE/ PRR | 1881 | 1885 | Pittsburgh, Marion and Chicago Railway |
| Newark, Somerset and Straitsville Railroad | | B&O | 1867 | 1900 | Ohio Midland Railroad |
| Newburgh and South Shore Railway | N&SS, NSS | | 1899 | 1986 | Cuyahoga Valley Railway, Newburgh and South Shore Railroad |
| Newport and Cincinnati Bridge Company | | L&N | 1868 | 1904 | Louisville and Nashville Railroad |
| Niles and New Lisbon Railway | | ERIE | 1869 | 1872 | Cleveland and Mahoning Valley Railway |
| Nimishillen and Tuscarawas Railway | NTRY | | 1990 | 2003 | Republic N&T Railroad |
| Norfolk and Western Railroad | | N&W | 1890 | 1896 | Norfolk and Western Railway |
| Norfolk and Western Railway | N&W, NW | N&W | 1896 | 1998 | Norfolk Southern Railway |
| North-Eastern Ohio Railroad | | B&LE | 1888 | 1888 | Pittsburgh, Shenango and Lake Erie Railroad |
| North Western Ohio Railroad | | WAB | 1880 | 1880 | Butler and Detroit Railroad |
| North Western Ohio Railroad | | NYC | 1871 | 1871 | Chicago and Canada Southern Railway |
| Northern Indiana Railroad | | NYC | 1851 | 1855 | Michigan Southern and Northern Indiana Railroad |
| Northern Ohio Railway | | ACY | 1895 | 1944 | Akron, Canton and Youngstown Railroad |
| Northwestern Ohio Railway | | PRR | 1876 | 1891 | Toledo, Walhonding Valley and Ohio Railroad |
| Nypano Railroad | | ERIE | 1896 | 1941 | Erie Railroad |
| Oberlin and La Grange Railway | | | | | |
| Ohio Railroad | | NYC | 1836 | 1852 | Junction Railroad |
| Ohio Railway | | | 1894 | 1894 | Findlay, Fort Wayne and Western Railway |
| Ohio Railway | | ACY | 1883 | 1887 | Pittsburgh, Akron and Western Railway |
| Ohio Railway | | NKP | 1879 | 1880 | New York, Fort Wayne and Chicago Railroad |
| Ohio Central Railroad | | NYC | 1879 | 1885 | Ohio and Kanawha Railway, Toledo and Ohio Central Railway |
| Ohio Central Railway | | NYC | 1876 | 1878 | Columbus and Sunday Creek Valley Railroad, Ohio Central Railroad |
| Ohio and Indiana Railroad | | PRR | 1850 | 1856 | Pittsburgh, Fort Wayne and Chicago Railroad |
| Ohio, Indiana and Missouri Railroad | | | | 1889 | American Midland Railway |
| Ohio, Indiana and Pacific Railway | | NYC | 1881 | 1881 | Indiana, Bloomington and Western Railway |
| Ohio and Indiana State Line Railroad | | NYC | 1880 | 1881 | Ohio, Indiana and Pacific Railway |
| Ohio, Indiana and Western Railway | | NYC | 1887 | 1890 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Ohio and Kanawha Railway | | NYC | 1886 | 1886 | Kanawha and Ohio Railway |
| Ohio and Kentucky Bridge Company | | C&O | 1886 | 1886 | Covington and Cincinnati Elevated Railroad and Transfer and Bridge Company |
| Ohio and Little Kanawha Railroad | | B&O | 1900 | 1966 | Baltimore and Ohio Railroad |
| Ohio Midland Railroad | | B&O | 1900 | 1915 | Baltimore and Ohio Railroad |
| Ohio and Mississippi Railroad | | B&O | 1848 | 1867 | Ohio and Mississippi Railway |
| Ohio and Mississippi Railway | | B&O | 1867 | 1893 | Baltimore and Ohio Southwestern Railway |
| Ohio and Morenci Railroad | | | 1933 | 1954 | N/A |
| Ohio and North Western Railroad | | N&W | 1886 | 1890 | Cincinnati, Portsmouth and Virginia Railroad |
| Ohio and Pennsylvania Railroad | | PRR | 1848 | 1856 | Pittsburgh, Fort Wayne and Chicago Railroad |
| Ohio and Pennsylvania Belt Line Railroad | | | | | |
| Ohio and Toledo Railroad | | W&LE | 1872 | 1878 | Youngstown and Connotton Valley Railroad |
| Ohio River Railway | | N&W | 1877 | 1890 | Scioto Valley Railway |
| Ohio River and Columbus Railway | | | | | |
| Ohio River and Lake Erie Railroad | | NYC | 1897 | 1901 | Lake Erie, Alliance and Wheeling Railroad |
| Ohio River and Western Railway | | PRR | 1902 | 1931 | Pittsburgh, Ohio Valley and Cincinnati Railroad |
| Ohio Southern Railroad | | DT&I | 1881 | 1898 | Detroit Southern Railroad |
| Ohio Valley Railway | | PRR | 1871 | 1890 | Pittsburgh, Ohio Valley and Cincinnati Railroad |
| Ohio Valley and Junction Railway | | PRR | 1897 | 1902 | Cleveland and Mahoning Railway |
| Ohio and West Virginia Railway | | C&O | 1878 | 1881 | Columbus, Hocking Valley and Toledo Railway |
| Painesville, Canton and Bridgeport Narrow Gauge Railroad | | W&LE | 1875 | 1880 | Chagrin Falls and Southern Railroad |
| Painesville and Hudson Railroad | | B&O | 1852 | 1870 | Painesville and Youngstown Railroad |
| Painesville, Wooster and Ohio Railway | | B&O | 1886 | 1890 | Lake Erie, Wooster and Muskingum Valley Railroad |
| Painesville and Youngstown Railroad | | B&O | 1870 | 1879 | Painesville and Youngstown Railway |
| Painesville and Youngstown Railway | | B&O | 1879 | 1886 | Pittsburg, Painesville and Fairport Railway |
| Paulding and Cecil Railway | | NYC | 1879 | 1887 | Cincinnati, Jackson and Mackinaw Railroad |
| Penn Central Transportation Company | PC | | 1968 | 1976 | Consolidated Rail Corporation |
| Penndel Company | | PRR | 1954 | 1976 | Consolidated Rail Corporation |
| Pennsylvania Company | | PRR | 1871 | 1918 | Pennsylvania Railroad |
| Pennsylvania Railroad | PRR | PRR | 1918 | 1968 | Penn Central Transportation Company |
| Pennsylvania, Ohio and Detroit Railroad | | PRR | 1926 | 1956 | Connecting Railway |
| Peoria and Eastern Railway | PAE | NYC | 1890 | 1914 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Pere Marquette Railroad | | PM | 1899 | 1917 | Pere Marquette Railway |
| Pere Marquette Railway | PM | PM | 1917 | 1947 | Chesapeake and Ohio Railway |
| Philadelphia, Baltimore and Washington Railroad | | PRR | 1956 | 1976 | Consolidated Rail Corporation |
| Pioneer and Fayette Railroad | PF | | 1933 | 1992 | N/A |
| Piqua and Troy Branch Railroad | | B&O | 1881 | 1943 | Toledo and Cincinnati Railroad |
| Pittsburgh, Akron and Western Railroad | | ACY | 1890 | 1894 | Northern Ohio Railway |
| Pittsburgh, Akron and Western Railway | | ACY | 1887 | 1890 | Pittsburgh, Akron and Western Railroad |
| Pittsburg, Bessemer and Lake Erie Railroad | | B&LE | 1897 | 1949 | Bessemer and Lake Erie Railroad |
| Pittsburgh and Chicago Railroad | | ACY | 1882 | 1887 | Cleveland and Western Railroad |
| Pittsburgh, Cincinnati, Chicago and St. Louis Railroad | | PRR | 1917 | 1956 | Philadelphia, Baltimore and Washington Railroad |
| Pittsburgh, Cincinnati, Chicago and St. Louis Railway | | PRR | 1890 | 1917 | Pittsburgh, Cincinnati, Chicago and St. Louis Railroad |
| Pittsburgh, Cincinnati and St. Louis Railway | | PRR | 1868 | 1890 | Pittsburgh, Cincinnati, Chicago and St. Louis Railway |
| Pittsburg, Cleveland and Toledo Railroad | | B&O | 1882 | 1915 | Baltimore and Ohio Railroad |
| Pittsburgh, Fort Wayne and Chicago Railroad | | PRR | 1856 | 1861 | Pittsburgh, Fort Wayne and Chicago Railway |
| Pittsburgh, Fort Wayne and Chicago Railway | | PRR | 1862 | 1976 | Consolidated Rail Corporation |
| Pittsburgh and Lake Erie Railroad | PLE | PLE | 1878 | 1992 | Three Rivers Railway |
| Pittsburgh, Lisbon and Western Railroad | PL&W, PLW | PLE/ PRR | 1902 | 1945 | Youngstown and Southern Railway |
| Pittsburgh, Lisbon and Western Railway | | PLE/ PRR | 1896 | 1902 | Pittsburgh, Lisbon and Western Railroad |
| Pittsburgh, Marion and Chicago Railway | | PLE/ PRR | 1885 | 1896 | Pittsburgh, Lisbon and Western Railway |
| Pittsburg, Maysville and Cincinnati Railroad | | B&O | 1853 | 1865 | South Western Railroad |
| Pittsburgh, Mount Vernon, Columbus and London Railroad | | PRR | 1869 | 1869 | Cleveland, Mount Vernon and Delaware Railroad |
| Pittsburgh, New Castle and Lake Erie Railroad | | B&O | 1877 | 1881 | Pittsburgh and Western Railroad |
| Pittsburgh and Northwestern Railroad | | B&O | 1875 | 1877 | Pittsburgh, New Castle and Lake Erie Railroad |
| Pittsburgh, Ohio Valley and Cincinnati Railroad | | PRR | 1890 | 1954 | Penndel Company |
| Pittsburg, Painesville and Fairport Railway | | B&O | 1886 | 1915 | Baltimore and Ohio Railroad |
| Pittsburgh, Shenango and Lake Erie Railroad | | B&LE | 1888 | 1897 | Pittsburg, Bessemer and Lake Erie Railroad |
| Pittsburgh, Toledo and Western Railroad | | P&WV | 1901 | 1904 | Wabash Pittsburgh Terminal Railway |
| Pittsburgh and West Virginia Railroad | | | 1967 | | | Still exists as a lessor of the Wheeling and Lake Erie Railway |
| Pittsburgh and West Virginia Railway | P&WV | P&WV | 1917 | 1967 | Pittsburgh and West Virginia Railroad |
| Pittsburgh and Western Railroad | | B&O | 1881 | 1887 | Pittsburgh and Western Railway |
| Pittsburgh and Western Railway | | B&O | 1887 | 1902 | N/A | Only entered Ohio through leases of other companies |
| Pittsburgh, Youngstown and Ashtabula Railroad | | PRR | 1887 | 1906 | Pittsburgh, Youngstown and Ashtabula Railway |
| Pittsburgh, Youngstown and Ashtabula Railway | | PRR | 1906 | 1976 | Consolidated Rail Corporation |
| Pittsburg, Youngstown and Chicago Railroad | | B&O | 1881 | 1882 | Pittsburg, Cleveland and Toledo Railroad |
| Pleasant Bay Railway | | CN/ NKP | 1899 | 1899 | Detroit and Toledo Shore Line Railroad |
| PL&W Railroad | PLW | | 1993 | 1995 | Ohio and Pennsylvania Railroad |
| Point Pleasant Bridge Company | | NYC | 1886 | 1935 | Kanawha and Michigan Railway |
| Point Pleasant and Ohio River Railroad | | NYC | 1883 | 1885 | Kanawha and Ohio Railway, Point Pleasant Bridge Company |
| Pomeroy Belt Railway | | C&O | 1909 | 1930 | Chesapeake and Ohio Railway |
| Pomeroy and Ohio River Railroad | | NYC | 1881 | 1883 | Point Pleasant and Ohio River Railroad |
| Port Clinton Railroad | | NYC | 1852 | 1853 | Cleveland and Toledo Railroad |
| Railroad Ventures, Inc. | | | 1996 | 2001 | Columbiana County Port Authority |
| Richland and Mahoning Railway | | ACY | 1898 | 1903 | Lake and River Railway |
| Richmond and Covington Railroad | | PRR | 1862 | 1864 | Columbus and Indianapolis Railroad |
| River Terminal Railway | RT | | 1909 | 2002 | Cleveland Works Railway |
| Rocky River Railroad | | NKP | 1867 | 1881 | New York, Chicago and St. Louis Railroad |
| Rolling Mill Railroad | | PRR | 1883 | 1904 | Toledo, Walhonding Valley and Ohio Railroad |
| St. Clairsville Railway | | B&O | 1880 | 1885 | Bellaire and St. Clairsville Railway |
| St. Clairsville and Northern Railway | | B&O | 1879 | 1945 | N/A |
| St. Joseph Valley Railway | | | | | |
| Salem Railroad | | PLE/ PRR | 1881 | 1902 | Pittsburgh, Lisbon and Western Railroad |
| Sandusky and Cincinnati Railroad | | NYC | 1866 | 1868 | Cincinnati, Sandusky and Cleveland Railroad |
| Sandusky City and Indiana Railroad | | NYC | 1851 | 1866 | Sandusky and Cincinnati Railroad |
| Sandusky and Columbus, Lake Erie and Southern Short Line Railway | | PRR | 1889 | 1891 | Sandusky and Columbus Short Line Railway |
| Sandusky and Columbus Short Line Railway | | PRR | 1891 | 1893 | Columbus, Sandusky and Hocking Railway |
| Sandusky, Dayton and Cincinnati Railroad | | NYC | 1858 | 1866 | Sandusky and Cincinnati Railroad |
| Sandusky and Fremont Railway | | NKP | 1880 | 1880 | Lake Erie and Western Railway |
| Sandusky, Mansfield and Newark Railroad | | B&O | 1854 | 1915 | Baltimore and Ohio Railroad |
| Sandyville and Waynesburg Railroad | | B&O | 1898 | 1914 | Cleveland Terminal and Valley Railway |
| Scioto and Hocking Valley Railroad | | B&O | 1849 | 1863 | Marietta and Cincinnati Railroad, Newark, Somerset and Straitsville Railroad |
| Scioto Valley Railway | | N&W | 1875 | 1890 | Scioto Valley and New England Railroad |
| Scioto Valley and New England Railroad | | N&W | 1890 | 1890 | Norfolk and Western Railroad |
| Seaboard System Railroad | SBD | | 1983 | 1986 | CSX Transportation |
| Sharon Railroad | | B&O | 1849 | 1853 | Pittsburg, Maysville and Cincinnati Railroad |
| Silica Northern Railway | | | 1912 | 1913 | Toledo, Angola and Western Railway |
| South Park and Royalton Railroad | | B&O | 1898 | 1916 | Baltimore and Ohio Railroad |
| South Pennsylvania and Ohio Railway | | NYC | 1883 | 1888 | Cleveland and Wheeling Railroad |
| South Western Railroad | | B&O | 1865 | 1871 | Eastern Ohio Railroad |
| Spring Grove, Avondale and Cincinnati Railway | | | 1881 | 1883 | Toledo, Cincinnati and St. Louis Railroad |
| Springfield and Columbus Railroad | | NYC | 1849 | 1868 | Columbus, Springfield and Cincinnati Railroad |
| Springfield, Jackson and Pomeroy Railroad | | DT&I | 1874 | 1879 | Springfield Southern Railroad |
| Springfield and Mansfield Railroad | | NYC, PRR | 1850 | 1852 | Springfield, Mount Vernon and Pittsburgh Railroad |
| Springfield, Mount Vernon and Pittsburgh Railroad | | NYC, PRR | 1852 | 1867 | Cleveland, Columbus and Cincinnati Railroad, Pittsburgh, Mount Vernon, Columbus and London Railroad |
| Springfield Southern Railroad | | DT&I | 1879 | 1881 | Ohio Southern Railroad |
| Springfield and Western Railway | | NYC | 1887 | 1887 | Ohio, Indiana and Western Railway |
| Sterling Belt Line Railway | SBLN | | 1984 | | N/A |
| Steubenville, Canton and Cleveland Railway | | NYC | 1881 | 1882 | Cleveland, Youngstown and Pittsburgh Railway |
| Steubenville and Indiana Railroad | | PRR | 1848 | 1868 | Pittsburgh, Cincinnati and St. Louis Railway |
| Sugar Creek and Northern Railroad | | W&LE | | | Wheeling and Lake Erie Railway |
| Sunday Creek Railroad | | B&O | 1901 | 1930 | N/A |
| Swan Creek Railway of Toledo | | NYC | 1875 | 1914 | New York Central Railroad |
| Tiffin and Fort Wayne Railroad | | NKP | 1854 | 1859 | American Central Railway |
| Toledo, Angola and Western Railway | TA&W, TAW | | 1902 | 1981 | N/A |
| Toledo and Ann Arbor Railroad | | AA | 1878 | 1880 | Toledo, Ann Arbor and Grand Trunk Railway |
| Toledo, Ann Arbor and Detroit Railroad | | DT&I | 1904 | 1912 | Toledo, Ann Arbor and Jackson Railroad |
| Toledo, Ann Arbor and Grand Trunk Railway | | AA | 1880 | 1884 | Toledo, Ann Arbor and North Michigan Railway |
| Toledo, Ann Arbor and Jackson Railroad | | DT&I | 1911 | 1915 | Toledo–Detroit Railroad |
| Toledo, Ann Arbor and North Michigan Railway | | AA | 1884 | 1895 | Ann Arbor Railroad |
| Toledo Belt Railway | | W&LE | 1883 | 1996 | Norfolk and Western Railway |
| Toledo, Canada Southern and Detroit Railway | | NYC | 1872 | 1916 | Michigan Central Railroad |
| Toledo and Chicago Railroad | | WAB | 1901 | 1901 | Wabash Railroad |
| Toledo and Cincinnati Railroad | | B&O | 1917 | 1944 | Baltimore and Ohio Railroad |
| Toledo, Cincinnati and St. Louis Railroad | | B&O, DT&I, NKP, PRR | 1882 | 1885 | Cincinnati, Lebanon and Northern Railway, Dayton and Ironton Railroad, Dayton, Lebanon and Cincinnati Railroad, Dayton and Toledo Railroad, Iron Railway, Toledo, Dupont and Western Railway |
| Toledo, Columbus and Cincinnati Railway | | NYC | 1889 | 1892 | Toledo and Ohio Central Railway |
| Toledo, Columbus and Ohio River Railroad | | PRR | 1911 | 1926 | Pennsylvania, Ohio and Detroit Railroad |
| Toledo, Columbus and Southern Railway | | NYC | 1885 | 1888 | Toledo, Columbus and Cincinnati Railway |
| Toledo, Delphos and Burlington Railroad | | B&O, DT&I, NKP | 1879 | 1882 | Toledo, Cincinnati and St. Louis Railroad |
| Toledo, Delphos and Indianapolis Railway | | B&O, NKP | 1872 | 1879 | Toledo, Delphos and Burlington Railroad |
| Toledo–Detroit Railroad | | DT&I | 1915 | 1931 | Detroit, Toledo and Ironton Railroad |
| Toledo Dock and Warehouse Company | | PRR | 1898 | 1903 | Manufacturers Railway |
| Toledo, Dupont and Western Railway | | NKP | 1886 | 1886 | Toledo, St. Louis and Kansas City Railroad |
| Toledo, Findlay and Springfield Railway | | B&O | 1889 | 1890 | Bowling Green Railroad |
| Toledo and Grand Rapids Railroad | | NKP | 1874 | 1881 | Toledo, Delphos and Burlington Railroad |
| Toledo and Illinois Railroad | | WAB | 1853 | 1856 | Toledo, Wabash and Western Railroad |
| Toledo and Indianapolis Railway | | NYC | 1881 | 1885 | Toledo, Columbus and Southern Railway |
| Toledo and Maumee Narrow Gauge Railroad | | NKP | 1873 | 1879 | Toledo, Delphos and Burlington Railroad |
| Toledo and Michigan Railway | | NYC | 1882 | 1883 | Michigan and Ohio Railroad |
| Toledo and Michigan Belt Railway | | NYC | 1887 | 1897 | Toledo, Canada Southern and Detroit Railway |
| Toledo and Michigan Terminal Railroad | | PRR | 1901 | 1903 | Manufacturers Railway |
| Toledo and Northwestern Railroad | | DT&I | 1904 | 1904 | Toledo, Ann Arbor and Detroit Railroad |
| Toledo, Norwalk and Cleveland Railroad | | NYC | 1850 | 1853 | Cleveland and Toledo Railroad |
| Toledo and Ohio Central Railway | | NYC | 1885 | 1952 | New York Central Railroad |
| Toledo and Ohio Central Extension Railroad | | | | | |
| Toledo and Ohio Northern Railway | | | | | |
| Toledo and Ottawa Beach Railway | | CN/ NKP | 1898 | 1899 | Pleasant Bay Railway |
| Toledo Railway and Terminal Company | | B&O/ CN/ C&O/ NKP/ NYC/ PM/ PRR | 1901 | 1907 | Toledo Terminal Railroad |
| Toledo and Rossford Railroad | | | | | |
| Toledo, St. Louis and Kansas City Railroad | | NKP | 1886 | 1900 | Toledo, St. Louis and Western Railroad |
| Toledo, St. Louis and Western Railroad | | NKP | 1900 | 1923 | New York, Chicago and St. Louis Railroad |
| Toledo Southeastern Railway | | | | | |
| Toledo and State Line Railroad | | AA | 1872 | 1878 | Toledo and Ann Arbor Railroad |
| Toledo Terminal Railroad | TT | B&O/ CN/ C&O/ NKP/ NYC/ PM/ PRR | 1907 | 1989 | CSX Transportation |
| Toledo, Tiffin and Eastern Railroad | | PRR | 1871 | 1876 | Northwestern Ohio Railway |
| Toledo and Wabash Railroad | | WAB | 1858 | 1858 | Toledo and Wabash Railway |
| Toledo and Wabash Railway | | WAB | 1858 | 1865 | Toledo, Wabash and Western Railway |
| Toledo, Wabash and Western Railroad | | WAB | 1856 | 1858 | Toledo and Wabash Railroad |
| Toledo, Wabash and Western Railway | | WAB | 1865 | 1876 | Wabash Railway |
| Toledo, Walhonding Valley and Ohio Railroad | | PRR | 1891 | 1911 | Toledo, Columbus and Ohio River Railroad |
| Toledo Western Railroad | | WAB | 1889 | 1889 | Wabash Railroad |
| Toledo and Woodville Railroad | | PRR | 1869 | 1878 | Northwestern Ohio Railway |
| Trumbull and Mahoning Railroad | | B&O | 1887 | 1915 | Baltimore and Ohio Railroad |
| Union Depot Company | | NYC/ PRR | 1872 | 1976 | Consolidated Rail Corporation |
| Union Railroad | | B&O | 1858 | 1860 | Marietta and Cincinnati Railroad |
| United Terminal Railway | | B&O | 1889 | 1895 | Marietta Railway |
| Valley Railway | | B&O | 1871 | 1895 | Cleveland Terminal and Valley Railway |
| Van Wert, Paulding and Michigan Railway | | NYC | 1874 | 1881 | Cincinnati, Van Wert and Michigan Railroad |
| Vandalia Railroad | | PRR | 1913 | 1917 | Pittsburgh, Cincinnati, Chicago and St. Louis Railroad |
| Wabash Railroad | WAB | WAB | 1942 | 1991 | Norfolk and Western Railway |
| Wabash Railroad | | WAB | 1889 | 1915 | Wabash Railway |
| Wabash Railway | | WAB | 1915 | 1942 | Wabash Railroad |
| Wabash Railway | | WAB | 1877 | 1879 | Wabash, St. Louis and Pacific Railway |
| Wabash Railway of Ohio | | WAB | 1876 | 1877 | Wabash Railway |
| Wabash Pittsburgh Terminal Railway | WPT | P&WV | 1904 | 1916 | Pittsburgh and West Virginia Railway |
| Wabash, St. Louis and Pacific Railway | | WAB | 1879 | 1886 | Detroit and State Line Wabash Railroad, Toledo Western Railroad |
| Wabash Western Railway | | WAB | 1889 | 1889 | Wabash Railroad |
| Walhonding Valley Railway | | PRR | 1889 | 1891 | Toledo, Walhonding Valley and Ohio Railroad |
| Waynesburg and Canton Railroad | | W&LE | 1888 | 1891 | Cleveland and Canton Railroad |
| Waynesville, Port William and Jeffersonville Railroad | | DT&I | 1875 | 1877 | Columbus, Washington and Cincinnati Railroad |
| Wellston and Jackson Belt Railway | | C&O | 1895 | 1930 | Chesapeake and Ohio Railway |
| Wheeling Bridge and Terminal Railway | | PRR | 1889 | 1900 | Wheeling Terminal Railway |
| Wheeling and Cincinnati Mineral Railway | | B&O | 1882 | 1883 | Cincinnati, Wheeling and New York Railroad |
| Wheeling and Cleveland Railroad | | NYC | 1895 | 1901 | Lake Erie, Alliance and Wheeling Railroad |
| Wheeling and Harrisburg Railway of West Virginia | | PRR | 1884 | 1889 | Wheeling Bridge and Terminal Railway |
| Wheeling and Lake Erie Railroad | | W&LE | 1899 | 1916 | Wheeling and Lake Erie Railway |
| Wheeling and Lake Erie Railroad | | W&LE | 1871 | 1886 | Wheeling and Lake Erie Railway |
| Wheeling and Lake Erie Railway | W&LE, WLE | W&LE | 1916 | 1988 | Norfolk and Western Railway |
| Wheeling and Lake Erie Railway | | W&LE | 1886 | 1899 | Wheeling and Lake Erie Railroad |
| Wheeling and Lake Erie Bridge Company | | W&LE | 1881 | 1887 | Wheeling and Lake Erie Railway |
| Wheeling Terminal Railway | | PRR | 1900 | 1954 | Penndel Company |
| Wicks and Wells Railroad | | ERIE | 1871 | 1882 | Youngstown and Austintown Railway |
| Youngstown Railroad | | ERIE | 1871 | 1882 | Youngstown and Austintown Railway |
| Youngstown and Austintown Railway | | ERIE | 1871 | 1941 | Erie Railroad |
| Youngstown and Canfield Railroad | | PRR | 1872 | 1873 | Lawrence Railroad |
| Youngstown and Connotton Valley Railroad | | W&LE | 1877 | 1879 | Connotton Valley Railroad |
| Youngstown, Lawrence and Pittsburgh Railroad | | PRR | 1887 | 1887 | Pittsburgh, Youngstown and Ashtabula Railroad |
| Youngstown, New Castle and Pittsburgh Railroad | | B&O | 1875 | 1875 | Pittsburgh and Northwestern Railroad |
| Youngstown and Northern Railroad | YN | | 1909 | 1981 | N/A |
| Youngstown and Pittsburg Railroad | | PLE | 1877 | 1878 | Pittsburgh and Lake Erie Railroad |
| Youngstown and Ravenna Railroad | | PRR | 1899 | 1954 | Penndel Company |
| Youngstown and Salem Railroad | | PLE/ PRR | 1903 | 1903 | Youngstown and Southern Railway |
| Youngstown and Southern Railway | YS | PLE/ PRR | 1944 | 1996 | Railroad Ventures, Inc. |
| Youngstown and Southern Railway | | PLE/ PRR | 1903 | 1916 | Youngstown and Suburban Railway |
| Youngstown and Suburban Railway | YS | PLE/ PRR | 1916 | 1944 | Youngstown and Southern Railway |
| Youngstown and State Line Railroad | | B&O | 1881 | 1881 | Pittsburgh and Western Railroad |
| Zanesville Belt and Terminal Railway | | W&LE | 1901 | 1948 | Wheeling and Lake Erie Railway |
| Zanesville, McConnellsville and Pomeroy Railway | | B&O | 1883 | 1885 | Chicago, Zanesville and Atlantic Railway |
| Zanesville, Mount Vernon and Marion Railway | | W&LE | 1886 | 1895 | Zanesville Belt and Terminal Railway |
| Zanesville and Ohio River Railway | | B&O | 1886 | 1900 | Ohio and Little Kanawha Railroad |
| Zanesville and South Eastern Railway | | PRR | 1881 | 1882 | Bellaire, Zanesville and Cincinnati Railway |
| Zanesville Terminal Railroad | | NYC/ PRR | 1902 | 1969 | Penndel Company |
| Zanesville Terminal Railway | | NYC/ PRR | 1890 | 1902 | Zanesville Terminal Railroad |
| Zanesville and Western Railway | | NYC | 1902 | 1938 | Toledo and Ohio Central Railway |
