| Train Name | Railroad | Train Endpoints | Operated |
| TEE Ambrosiano | Ferrovie dello Stato | Milan (Central) – Rome (Termini) | 1974–1987 |
| Bernina Express | RhB | Tirano – St. Moritz – Chur | present |
| Brenner Express | Trenitalia, ÖBB, DB | Florence (Firenze Santa Maria Novella) – Munich (Hauptbahnhof)
Venice (Santa Lucia) – Munich (Hauptbahnhof) | present |
| Capri | Trenitalia, ÖBB, DB | Naples – Munich (Hauptbahnhof) | present |
| Caravaggio | Trenitalia, SNCF | Milan (Central) – Torino – Paris (Lyon) | present |
| Casanova | Trenitalia, SŽ | Venice (Santa Lucia) – Ljubljana (Main) | 2001–2008 |
| Conca d'Oro | Trenitalia | Milan (Central) – Palermo | present |
| Don Giovanni | ČD, ÖBB, Trenitalia | Venice (Santa Lucia) – Vienna (Westbahnhof) – Prague (Main) | present |
| Dumas | Trenitalia, SNCF | Milan (Central) – Torino – Paris (Lyon) | present |
| EC Borromeo | Cisalpino | Milan (Central) – Bern (Main) – Basel | present |
| EC Canaletto | Cisalpino | Venice (Santa Lucia) – Zurich (Hauptbahnhof) | present |
| EC Cinque Terre | Cisalpino | La Spezia – Zurich (Hauptbahnhof) | present |
| EC Lemano | Cisalpino | Milan (Central) – Geneva | present |
| EC Mediolanum | Cisalpino | Milan (Central) – Basel (SBB station) | 2004–present |
| EC Monte Rosa | Cisalpino | Milan (Central) – Geneva | present |
| EC Verbano | Cisalpino | Milan (Central) – Bern (Main) – Basel | present |
| EC Vall D’Ossola | Cisalpino | Milan (Central) – Bern (Main) – Basel | present |
| EC Vallese | Cisalpino | Milan (Central) – Geneva | present |
| EN Roma | Trenitalia, SBB-CFF-FFS | Venice (Santa Lucia) – Zurich (Hauptbahnhof)
Rome (Termini) – Zurich (Hauptbahnhof) | present |
| Freccia del Sud | Trenitalia | Milano – Siracusa – Agrigento | present |
| Garda | Trenitalia, ÖBB, DB | Verona – München | present |
| Giacomo Puccini | Trenitalia, ÖBB | Ancona – Vienna (Südbahnhof) | present |
| Goldoni | Trenitalia, SŽ, HŽ, MÁV | Venice (Santa Lucia) – Ljubljana (Main) – Zagreb – Budapest (Nyugati) | present |
| Gottardo | SBB-CFF-FFS, FS/Trenitalia, Cisalpino | Milan (Central) – Zurich (Hauptbahnhof) | 1961–2008 |
| Heidi Express | RhB | Tirano – St. Moritz – Chur | present |
| IC Brianza | Cisalpino | Milan (Central) – Bellinzona | present |
| IC Insubria | Trenitalia, SBB-CFF-FFS | Milan (Central) – Zurich (Hauptbahnhof) – Stuttgart (Hauptbahnhof) | present |
| IC Mediolanum | Trenitalia, SBB-CFF-FFS | Milan (Central) – Lucerne (Main) – Basel | 2001–2004 |
| IC Monte Ceneri | Trenitalia, SBB-CFF-FFS | Milan (Central) – Zurich (Hauptbahnhof) | present |
| IC Riviera dei Fiori | Trenitalia, SBB-CFF-FFS | Basel – Lucerne – Genoa – Nice | present |
| IC Teodolina | Trenitalia, SBB-CFF-FFS | Milan (Central) – Zurich (Hauptbahnhof) | present |
| IC Ticino | Trenitalia, SBB-CFF-FFS | Milan (Central) – Lucerne (Main) – Basel | present |
| IC Tiziano | Trenitalia, SBB-CFF-FFS | Milan (Central) – Lucerne (Main) – Basel | present |
| IC Verdi | Trenitalia, SBB-CFF-FFS | Milan (Central) – Lucerne (Main) – Basel | present |
| Italicus | Trenitalia | Rome (Termini) – Munich (Hauptbahnhof) | discontinued in 1974 after a terrorist attack |
| Johann Strauss | Trenitalia, ÖBB | Venice (Santa Lucia) – Vienna (Westbahnhof) | present |
| Leonardo da Vinci | Trenitalia, ÖBB, DB | Milan (Central) – Munich (Hauptbahnhof) | present |
| Ligure | FS/Trenitalia, SNCF | Milan (Central) – Nice – Avignon | 1957–2009 |
| Manzoni | Trenitalia, SNCF | Milan (Central) – Torino – Paris (Lyon) | present |
| TEE/IC Mediolanum | FS, ÖBB, DB | Milan (Central) – Munich (Hauptbahnhof) | 1957–1987 |
| Michelangelo | Trenitalia, ÖBB, DB | Rome (Termini) – Munich (Hauptbahnhof) | present |
| Montecarlo | Trenitalia, SNCF | Naples – Nice | present |
| Paganini | Trenitalia, ÖBB, DB | Verona – Munich (Hauptbahnhof) | present |
| Palatino Express | Trenitalia, SNCF | Rome (Termini) – Florence (Firenze Santa Maria Novella) – Bologna (Central) – Paris (Lyon) | Discontinued in December 2011 |
| San Marco | Trenitalia, ÖBB | Venice (Santa Lucia) – Vienna (Westbahnhof) | present |
| Sanremo | Trenitalia, SNCF | Milan (Central) – Nice | present |
| Settebello | FS | Milan (Central) – Rome (Termini) | 1953–1984 |
| Stendhal | Trenitalia, SNCF | Venice (Santa Lucia) – Milan (Central) – Paris (Lyon) | present |
| Stradivari | Trenitalia, ÖBB | Venice (Santa Lucia) – Vienna (Westbahnhof) | present |
| Tacito | Trenitalia | Terni – Milan (Central) | present |
| Tiepolo | Trenitalia, ÖBB, DB | Florence (Firenze Santa Maria Novella) – Munich (Hauptbahnhof)
Venice (Santa Lucia) – Munich (Hauptbahnhof) | present |
| Tosca | Trenitalia, ÖBB | Rome (Termini) – Vienna (Westbahnhof) | present |
| Trenino della neve | RhB | Tirano – St. Moritz | present |
| Trenino Verde | (tourist train) | Mandas – Arbatax | end of 19th century – present |
| Val Gardena | Trenitalia, ÖBB, DB | Bolzano – Munich (Hauptbahnhof) | present |
| Venezia | Trenitalia, SŽ, HŽ, MÁV, CFR | Venice (Santa Lucia) – Ljubljana (Main) – Zagreb – Budapest (Nyugati) – Bucharest (Gara de Nord) | present |