| Train or service name | Railroad | Route endpoints | Operated |
| Alpenrhein Express | SOB | Chur – St. Gallen | 2024–present |
| Aare Linth | SOB | Chur – Zurich (Hauptbahnhof) – Bern | 2021–present |
| AB-Klassiker | AB | Appenzell – Wasserauen | present |
| Aqualino[1] | RhB | Scuol-Tarasp – Chur – Disentis/Muster | present |
| Bernina Express | RhB | Chur – St. Moritz – Tirano | 1973–present |
| CNL Apus | CNL | Amsterdam (Centraal) – Bellinzona – Milan (Central) | present |
| CNL Aurora | CNL | Zurich (Hauptbahnhof) – Copenhagen (Central) | present |
| CNL Berliner | CNL | Zurich (Hauptbahnhof) – Berlin (Hauptbahnhof) | present |
| CNL Canopus | CNL | Zurich (Hauptbahnhof) – Prague (Central) | present |
| CNL Komet | CNL | Zurich (Hauptbahnhof) – Hamburg (Hauptbahnhof) | present |
| CNL Orion | CNL | Basel – Dresden (Hauptbahnhof) – Prague (Main) | present |
| CNL Pegasus | CNL | Amsterdam (Centraal) – Zurich (Hauptbahnhof) – Brig | present |
| CNL Semper | CNL | Zurich (Hauptbahnhof) – Dresden (Hauptbahnhof) | present |
| EC Borromeo | Cisalpino | Basel – Bern (Main) – Milan (Central) | until 2009 |
| EC Canaletto | Cisalpino | Zurich (Hauptbahnhof) – Venice (Santa Lucia) | until 2009 |
| EC Cinque Terre | Cisalpino | Zurich (Hauptbahnhof) – La Spezia | until 2009 |
| EC Iris | SNCB, CFL, SNCF, SBB CFF FFS | Brussels (Midi/Zuid) – Strasbourg – Chur | present |
| EC Jean Monet | SNCB, CFL, SNCF | Brussels (Midi/Zuid) – Strasbourg – Basel | present |
| EC Kaiserin Elisabeth | SBB CFF FFS, ÖBB | Zurich (Hauptbahnhof) – Salzburg | present |
| EC Lemano | Cisalpino | Geneva – Milan (Central) | until 2009 |
| EC Maria Theresia | SBB CFF FFS, ÖBB | Zurich (Hauptbahnhof) – Vienna (Westbahnhof) | present |
| EC Monte Rosa | Cisalpino | Geneva – Milan (Central) | until 2009 |
| EC Ticino | SBB CFF FFS, FS/Trenitalia, Cisalpino | Basel – Lucerne – Milan (Central) | 1993–2008 |
| EC Transalpin | SBB CFF FFS, ÖBB | Basel – Vienna (Westbahnhof) | 1958–2010 |
| SBB CFF FFS, ÖBB | Zurich (Hauptbahnhof) – Graz (Hauptbahnhof) | 2013–present |
| EC Vall D’Ossola | Cisalpino | Basel – Bern (Main) – Milan (Central) | until 2009 |
| EC Vallese | Cisalpino | Geneva – Milan (Central) | until 2009 |
| EC Vauban | SNCB, CFL, SNCF, SBB CFF FFS | Brussels (Midi/Zuid) – Strasbourg – Brig | present |
| EC Verbano | Cisalpino | Basel – Bern (Main) – Milan (Central) | until 2009 |
| EN Roma | SBB CFF FFS, Trenitalia | Zurich (Hauptbahnhof) – Venice (Santa Lucia) Zurich (Hauptbahnhof) – Rome (Termini) | present |
| EN Wiener Walzer | SBB CFF FFS, ÖBB, MÁV | Zurich (Hauptbahnhof) – Prague (Main) Zurich (Hauptbahnhof) – Vienna (Westbahnhof) – Budapest (Keleti) | present |
| EN Zürichsee | SBB CFF FFS, ÖBB, SŽ, HŽ, ŽS | Zurich (Hauptbahnhof) – Ljubljana (Main) – Zagreb – Beograd | present |
| Engadin Star[2] | RhB | Landquart – St. Moritz | present |
| Glacier Express | MGB, RhB | Zermatt – St. Moritz | present |
| Glarner Sprinter | SBB CFF FFS | Zurich (Hauptbahnhof) – Linthal | 2004–2014 |
| GoldenPass Line | Zentralbahn, BLS, Montreux–Lenk im Simmental line | Lucerne – Interlaken – Zweisimmen – Montreux | present |
| Gotthard Panorama Express | SBB CFF FFS, SGV | (Lucerne by boat to) Flüelen – Bellinzona – Lugano | 2017–present |
| Heidi Express (currently the Bernina Express) | RhB | Chur – St. Moritz – Tirano | present |
| IC Brianza | Cisalpino | Bellinzona – Milan (Central) | until 2009 |
| IC Insubria | SBB CFF FFS, Trenitalia | Stuttgart (Hauptbahnhof) – Zurich (Hauptbahnhof) – Milan (Central) | present |
| IC Mediolanum | SBB CFF FFS, Trenitalia | Basel – Lucerne – Milan (Central) | present |
| IC Monte Ceneri | Cisalpino | Zurich (Hauptbahnhof) – Milan (Central) | until 2009 |
| IC Riviera dei Fiori | Cisalpino | Basel – Lucerne – Genova – Nice | until 2009 |
| IC Teodolina | Cisalpino | Zurich (Hauptbahnhof) – Milan (Central) | until 2009 |
| IC Tiziano | SBB CFF FFS, Trenitalia | Basel – Lucerne – Milan (Central) | present |
| IC Verdi | SBB CFF FFS, Trenitalia | Basel – Lucerne – Milan (Central) | present |
| RE Lötschberg[3] | BLS | Spiez – Kandersteg – Goppenstein (Lötschental) – Brig | present |
| Rheingold | | Basel – Hook of Holland | 1934–1987 |
| Rheintal Express | SBB CFF FFS | St. Gallen – Chur | 1995–2018 |
| Rhyhas | SBB GmbH | Schaffhausen – Singen (– Radolfzell) | 2022–present |
| TEE Gottardo | SBB CFF FFS, FS | Zurich – Milan (Central) | 1961–1988 |
| TEE Ticino | SBB CFF FFS | Zurich – Milan (Central) | 1961–1974 |
| Train des Vignes | SBB CFF FFS | Vevey – Puidoux-Chexbres | present |
| Train du Chocolat[4] | TPF | Montreux – Gruyères – Broc | present |
| Train Fondue | TPF | (Montreux) – Montbovon – Bulle | present |
| Trenhotel Pau Casals | Elipsos | Zurich (Hauptbahnhof) – Barcelona (Estació de França) | 2001–2012 |
| Trenino della Neve | RhB | St. Moritz – Tirano | present |
| Treno Gottardo | SOB, SBB CFF FFS | Locarno – Airolo – Göschenen – Arth-Goldau – Zurich (Hauptbahnhof) or Basel (SBB) | 2020–present |
| Voralpen Express | SOB (until 2013 in collaboration with SBB CFF FFS) | Lucerne – Rapperswil – St. Gallen ( – Romanshorn, until 2013) | 1992–present |
| Wilhelm-Tell-Express | SBB CFF FFS, SGV | (Lucerne by boat to) Flüelen – Bellinzona – Lugano | until 2017 |