| Name of place | Number of counties | Principal county | Lower zip code | Upper zip code |
| Sagwon | 1 | North Slope Borough | | |
| St. George | 1 | Aleutians West Census Area | 99591 | |
| St. George | 1 | Aleutians West Census Area | 99660 | |
| Saint George Island | 1 | Aleutians West Census Area | 99660 | |
| St. John Harbor | 1 | Wrangell-Petersburg Census Area | | |
| Saint Marys | 1 | Kusilvak Census Area | 99658 | |
| Saint Mary's | 1 | Kusilvak Census Area | 99658 | |
| St. Mary's | 1 | Kusilvak Census Area | 99658 | |
| Saint Marys Airport | 1 | Kusilvak Census Area | 99658 | |
| St. Marys City School District | 1 | Kusilvak Census Area | | |
| Saint Michael | 1 | Nome Census Area | 99659 | |
| St. Michael | 1 | Nome Census Area | 99659 | |
| Saint Paul | 1 | Aleutians West Census Area | 99660 | |
| St. Paul | 1 | Aleutians West Census Area | 99660 | |
| Saint Paul Island | 1 | Aleutians West Census Area | 99660 | |
| Saint Paul Island Airport | 1 | Aleutians West Census Area | 99660 | |
| Saint Terese | 1 | City and Borough of Juneau | | |
| Salamatof | 1 | Kenai Peninsula Borough | | |
| Salcha | 1 | Fairbanks North Star Borough | 99714 | |
| Salchaket | 1 | Fairbanks North Star Borough | 99701 | |
| Salmon | 1 | Yukon-Koyukuk Census Area | | |
| Salmon Creek | 1 | City and Borough of Juneau | 99801 | |
| Salmon Lake | 1 | Nome Census Area | | |
| Salt Chuck | 1 | Prince of Wales-Outer Census Area | | |
| Sanak | 1 | Aleutians East Borough | | |
| Sand Bay | 1 | Aleutians East Borough | | |
| Sand Lake | 1 | Municipality of Anchorage | 99522 | |
| Sand Point | 1 | Aleutians East Borough | 99661 | |
| Sand Point Airport | 1 | Aleutians East Borough | 99661 | |
| San Juan | 1 | Kodiak Island Borough | | |
| Saulich | 1 | Yukon-Koyukuk Census Area | | |
| Savonoski | 1 | Bristol Bay Borough | | |
| Savoonga | 1 | Nome Census Area | 99769 | |
| Saxman | 1 | Ketchikan Gateway Borough | 99901 | |
| Saxman East | 1 | Ketchikan Gateway Borough | | |
| Scammon Bay | 1 | Kusilvak Census Area | 99662 | |
| Scow Bay | 1 | Wrangell-Petersburg Census Area | 99833 | |
| Sealaska | 8 | Haines Borough | | |
| Sealaska | 8 | City and Borough of Juneau | | |
| Sealaska | 8 | Ketchikan Gateway Borough | | |
| Sealaska | 8 | Prince of Wales-Outer Census Area | | |
| Sealaska | 8 | City and Borough of Sitka | | |
| Sealaska | 8 | Skagway-Hoonah-Angoon Census Area | | |
| Sealaska | 8 | Wrangell-Petersburg Census Area | | |
| Sealaska | 8 | City and Borough of Yakutat | | |
| Section House | 1 | Matanuska-Susitna Borough | | |
| Selawik | 1 | Northwest Arctic Borough | 99770 | |
| Seldovia | 1 | Kenai Peninsula Borough | 99663 | |
| Seldovia Village | 1 | Kenai Peninsula Borough | | |
| Serpentine Hot Springs | 1 | Nome Census Area | | |
| Seversens | 1 | Dillingham Census Area | | |
| Seward | 1 | Kenai Peninsula Borough | 99664 | |
| Seward-Hope | 1 | Kenai Peninsula Borough | | |
| Shageluk | 1 | Yukon-Koyukuk Census Area | 99665 | |
| Shaktolik | 1 | Nome Census Area | | |
| Shaktoolik | 1 | Nome Census Area | 99771 | |
| Sheldon Point | 1 | Kusilvak Census Area | 99666 | |
| Sheldon Point | 1 | Kusilvak Census Area | | |
| Shemya | 1 | Aleutians East Borough | | |
| Shemya Island | 1 | Aleutians East Borough | | |
| Shemya Station/Air Force Station | 1 | Aleutians West Census Area | 98736 | |
| Sherman | 1 | Matanuska-Susitna Borough | | |
| Sheshalik | 1 | Northwest Arctic Borough | | |
| Shishmaref | 1 | Nome Census Area | 99772 | |
| Shoal Cove | 1 | Ketchikan Gateway Borough | | |
| Shoreline Drive | 1 | Ketchikan Gateway Borough | | |
| Shungnak | 1 | Northwest Arctic Borough | 99773 | |
| Shungnak Village | 1 | Northwest Arctic Borough | | |
| Silver Springs | 1 | Valdez-Cordova Census Area | | |
| Silvertip | 1 | Kenai Peninsula Borough | 99631 | |
| Sinuk | 1 | Nome Census Area | | |
| Sitka | 1 | City and Borough of Sitka | 99835 | |
| Sitka | 1 | City and Borough of Sitka | | |
| Sitka Airport | 1 | City and Borough of Sitka | 99835 | |
| Sitka City and Borough School District | 1 | City and Borough of Sitka | | |
| Sitka National Historical Park | 1 | City and Borough of Sitka | | |
| Situk | 1 | City and Borough of Yakutat | | |
| Skagway | 1 | Municipality of Skagway Borough | 99840 | |
| Skagway City School District | 1 | Municipality of Skagway Borough | | |
| Skwentna | 1 | Matanuska-Susitna Borough | 99667 | |
| Slana | 1 | Valdez-Cordova Census Area | 99586 | |
| Slaterville | 1 | Fairbanks North Star Borough | | |
| Sleetmute | 1 | Bethel Census Area | 99668 | |
| Snug Harbor | 1 | Kenai Peninsula Borough | 99572 | |
| Soldatna | 1 | Kenai Peninsula Borough | | |
| Soldotna | 1 | Kenai Peninsula Borough | 99669 | |
| Solomon | 1 | Nome Census Area | | |
| Sourdough | 1 | Valdez-Cordova Census Area | 99586 | |
| South | 1 | Municipality of Anchorage | 99502 | |
| South Bierremark | 1 | Fairbanks North Star Borough | | |
| Southeast Fairbanks | 1 | Southeast Fairbanks Census Area | | |
| Southeast Islands Regional Educational Attendance Ar | 2 | Prince of Wales-Outer Census Area | | |
| Southeast Islands Regional Educational Attendance Ar | 2 | Wrangell-Petersburg Census Area | | |
| South Fairbanks | 1 | Fairbanks North Star Borough | 99701 | |
| South Naknek | 1 | Bristol Bay Borough | 99670 | |
| Southwest Region Regional Educational Attendance Are | 1 | Dillingham Census Area | | |
| Sparrevohn Station | 1 | Bethel Census Area | | |
| Spenard | 1 | Municipality of Anchorage | 99503 | |
| Squaw Harbor | 1 | Aleutians East Borough | 99661 | |
| Standard | 1 | Fairbanks North Star Borough | | |
| Stebbins | 1 | Nome Census Area | 99671 | |
| Steese | 1 | Fairbanks North Star Borough | 99710 | |
| Sterling | 1 | Kenai Peninsula Borough | 99672 | |
| Sterling Landing | 1 | Yukon-Koyukuk Census Area | | |
| Stevens | 1 | Yukon-Koyukuk Census Area | | |
| Stevens Village | 1 | Yukon-Koyukuk Census Area | 99774 | |
| Stony River | 1 | Bethel Census Area | 99557 | |
| Strawberry Point | 1 | Skagway-Hoonah-Angoon Census Area | | |
| Strelna | 1 | Valdez-Cordova Census Area | | |
| Stuyahok | 1 | Kusilvak Census Area | | |
| Sulatna Crossing | 1 | Yukon-Koyukuk Census Area | | |
| Sullivan Camp | 1 | Nome Census Area | | |
| Summit | 1 | Denali Borough | 99729 | |
| Sunnyside | 1 | Skagway-Hoonah-Angoon Census Area | 99832 | |
| Sunrise | 1 | Kenai Peninsula Borough | | |
| Sunshine | 1 | Matanuska-Susitna Borough | 99501 | |
| Suntrana | 1 | Denali Borough | 99743 | |
| Susitna | 1 | Matanuska-Susitna Borough | | |
| Sutton | 1 | Matanuska-Susitna Borough | 99674 | |
| Sutton-Alpine | 1 | Matanuska-Susitna Borough | | |