The lysophosphatidic acid receptors (LPARs) are a group of G protein-coupled receptors for lysophosphatidic acid (LPA) that include:
See also
References
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| Extracellular | | Eicosanoids | |
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| Lysophospholipids | |
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| Steroids | |
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| Others | |
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| Intracellular | | Nuclear receptor | |
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| Second messenger | - General: Arachidonic acid
- DAG (PKC, TRPC)
- IP3 (IP3R, RyR)
- Phosphatidic acid
- Phosphoinositides: PIP2 (IRKs)
- PIP3 (PKB/Akt, Btk, PDPK1)
- PtdIns(3,4)P2 (PKB/Akt, PDPK1); Sphingolipids: C1P
- Ceramide (CAPPs, KSR1, PKCζ, CTSD)
- Glucosylceramides
- S1P
- Sphingosine (SDK1, PKH, YPK)
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| Precursors | |
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Receptor (ligands) | | Tooltip Lysophosphatidic acid receptor | - Agonists: 1-Oleoyl-LPA
- 1-Palmitoyl-LPA
- GRI-977143
- LPA
- OMPT
- Antagonists: H2L-5186303
- H2L-5765834
- Ki-16425
- TC-LPA5 4
- VPC-32183
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| S1PRTooltip Sphingosine-1-phosphate receptor | - Agonists: Amiselimod
- Cenerimod
- Ceralifimod
- CS-2100
- CYM-5442
- CYM-5520
- CYM 5541
- CYM-50260
- CYM-50308
- Dihydro-S1P (sphinganine 1-phosphate)
- Fingolimod
- Fingolimod phosphate
- KRP-203
- Mocravimod
- Ozanimod
- Phyto-S1P
- Ponesimod
- RP-001
- RP-002
- RPC-1063
- SEW-2871
- Siponimod
- S1P
- SPC
- TC-G 1006
- TC-SP 14
- W-061
- XAX-162
- Antagonists: CS-0777
- CYM-50358
- JTE-013
- TY-52156
- VPC-23019
- W-146
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Enzyme (inhibitors) | |
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| Others | |
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See also: Receptor/signaling modulators |