| Office | Name | Party | Term |
| |
| Head of Government | Benito Mussolini | | National Fascist Party | 31 October 1922 – 25 July 1943 |
| |
| Minister of Foreign Affairs | Benito Mussolini (ad interim) | | National Fascist Party | 31 October 1922 – 12 September 1929 |
| Dino Grandi | | National Fascist Party | 12 September 1929 – 20 July 1932 |
| Benito Mussolini (ad interim) | | National Fascist Party | 20 July 1932 – 11 June 1936 |
| Galeazzo Ciano | | National Fascist Party | 11 June 1936 – 6 February 1943 |
| Benito Mussolini (ad interim) | | National Fascist Party | 6 February 1943 – 25 July 1943 |
| |
| Minister of the Interior | Benito Mussolini (ad interim) | | National Fascist Party | 31 October 1922 – 17 June 1924 |
| Luigi Federzoni | | National Fascist Party | 17 June 1924 – 6 November 1926 |
| Benito Mussolini (ad interim) | | National Fascist Party | 6 November 1926 – 25 July 1943 |
| |
| Minister of Public Works | Gabriello Carnazza | | Social Democracy | 31 October 1922 – 1 July 1924 |
| Gino Sarrocchi | | National Fascist Party | 1 July 1924 – 5 January 1925 |
| Giovanni Giuriati | | National Fascist Party | 5 January 1925 – 30 April 1929 |
| Benito Mussolini (ad interim) | | National Fascist Party | 30 April 1929 – 12 September 1929 |
| Michele Bianchi | | National Fascist Party | 12 September 1929 – 3 February 1930 † |
| Araldo di Crollalanza | | National Fascist Party | 13 February 1930 – 24 January 1935 |
| Luigi Razza | | National Fascist Party | 24 January 1935 – 7 August 1935 † |
| Giuseppe Cobolli Gigli | | National Fascist Party | 5 September 1935 – 31 October 1939 |
| Adelchi Serena | | National Fascist Party | 31 October 1939 – 30 October 1940 |
| Giuseppe Gorla | | National Fascist Party | 30 October 1940 – 6 February 1943 |
| Zenone Benini | | National Fascist Party | 6 February 1943 – 25 July 1943 |
| |
| Minister of Treasury | Vincenzo Tangorra | | Italian People's Party | 31 October 1922 – 21 December 1922 |
| Alberto de' Stefani | | National Fascist Party | 21 December 1922 – 31 December 1922 |
| |
| Minister of Labour and Social Security | Stefano Cavazzoni | | Italian People's Party | 31 October 1922 – 26 April 1923 |
| |
| Minister of Agriculture | Giuseppe De Capitani D'Arzago | | Italian Liberal Party | 31 October 1922 – 1 August 1923 |
| |
| Minister of Industry and Commerce | Teofilo Rossi | | Italian Liberal Party | 31 October 1922 – 1 August 1923 |
| |
| Minister of National Economy | Orso Mario Corbino | | Italian Liberal Party | 1 August 1923 – 1 July 1924 |
| Cesare Nava | | National Fascist Party | 1 July 1924 – 10 July 1925 |
| Giuseppe Belluzzo | | National Fascist Party | 10 July 1925 – 9 July 1928 |
| Alessandro Martelli | | National Fascist Party | 9 July 1928 – 12 September 1929 |
| |
| Minister of Justice and Worship Affairs | Aldo Oviglio | | National Fascist Party | 31 October 1922 – 5 January 1925 |
| Alfredo Rocco | | National Fascist Party | 5 January 1925 – 19 July 1932 |
| |
| Minister of Grace and Justice | Pietro De Francisci | | National Fascist Party | 20 July 1932 – 24 January 1935 |
| Arrigo Solmi | | National Fascist Party | 24 January 1935 – 12 July 1939 |
| Dino Grandi | | National Fascist Party | 12 July 1939 – 6 February 1943 |
| Alfredo De Marsico | | National Fascist Party | 6 February 1943 – 25 July 1943 |
| |
| Minister of War | Armando Diaz | | Military | 31 October 1922 – 30 April 1924 |
| Antonino Di Giorgio | | National Fascist Party | 30 April 1924 – 4 April 1925 |
| Benito Mussolini (ad interim) | | National Fascist Party | 4 April 1925 – 12 September 1929 |
| Pietro Gazzera | | National Fascist Party | 12 September 1929 – 22 July 1933 |
| Benito Mussolini (ad interim) | | National Fascist Party | 22 July 1933 – 25 July 1943 |
| |
| Minister of the Navy | Paolo Thaon di Revel | | Military | 31 October 1922 – 8 May 1925 |
| Benito Mussolini (ad interim) | | National Fascist Party | 8 May 1925 – 12 September 1929 |
| Giuseppe Sirianni | | National Fascist Party | 12 September 1929 – 6 November 1933 |
| Benito Mussolini (ad interim) | | National Fascist Party | 6 November 1933 – 25 July 1943 |
| |
| Minister of Public Education | Giovanni Gentile | | Independent | 31 October 1922 – 1 July 1924 |
| Alessandro Casati | | Independent | 1 July 1924 – 5 January 1925 |
| Pietro Fedele | | National Fascist Party | 5 January 1925 – 9 July 1928 |
| Giuseppe Belluzzo | | National Fascist Party | 9 July 1928 – 12 September 1929 |
| |
| Minister of National Education | Balbino Giuliano | | National Fascist Party | 12 September 1929 – 20 July 1932 |
| Francesco Ercole | | National Fascist Party | 20 July 1932 – 24 January 1935 |
| Cesare Maria De Vecchi | | National Fascist Party | 24 January 1935 – 15 November 1936 |
| Giuseppe Bottai | | National Fascist Party | 15 November 1936 – 5 February 1943 |
| Carlo Alberto Biggini | | National Fascist Party | 5 February 1943 – 25 July 1943 |
| |
| Minister of the Colonies | Luigi Federzoni | | Italian Nationalist Association | 31 October 1922 – 17 June 1924 |
| Benito Mussolini (ad interim) | | National Fascist Party | 17 June 1924 – 1 July 1924 |
| Pietro Lanza di Scalea | | National Fascist Party | 1 July 1924 – 6 November 1926 |
| Luigi Federzoni | | National Fascist Party | 6 November 1926 – 18 December 1928 |
| Benito Mussolini (ad interim) | | National Fascist Party | 18 December 1928 – 12 September 1929 |
| Emilio De Bono | | National Fascist Party | 12 September 1929 – 17 January 1935 |
| Benito Mussolini (ad interim) | | National Fascist Party | 17 January 1935 – 11 June 1936 |
| |
| Minister of Italian Africa | Alessandro Lessona | | National Fascist Party | 11 June 1936 – 20 November 1937 |
| Benito Mussolini (ad interim) | | National Fascist Party | 20 Novembre 1937 – 31 October 1939 |
| Attilio Teruzzi | | National Fascist Party | 31 October 1939 – 25 July 1943 |
| |
| Minister of Finance | Alberto de' Stefani | | National Fascist Party | 31 October 1922 – 10 July 1925 |
| Giuseppe Volpi | | National Fascist Party | 10 July 1925 – 9 July 1928 |
| Antonio Mosconi | | National Fascist Party | 9 July 1928 – 20 July 1932 |
| Guido Jung | | National Fascist Party | 20 July 1932 – 24 January 1935 |
| Paolo Ignazio Maria Thaon di Revel | | National Fascist Party | 24 January 1935 – 6 February 1943 |
| Giacomo Acerbo | | National Fascist Party | 6 February 1943 – 25 July 1943 |
| |
| Minister of Post and Telegraphs | Giovanni Antonio Colonna | | Social Democracy | 31 October 1922 – 5 February 1924 |
| Costanzo Ciano | | National Fascist Party | 5 February 1924 – 3 March 1924 |
| |
| Minister of Communications | Costanzo Ciano | | National Fascist Party | 3 March 1924 – 30 April 1934 |
| Umberto Puppini | | National Fascist Party | 30 April 1934 – 24 January 1935 |
| Antonio Stefano Benni | | National Fascist Party | 24 January 1935 – 31 October 1939 |
| Giovanni Host-Venturi | | National Fascist Party | 31 October 1939 – 6 February 1943 |
| Vittorio Cini | | National Fascist Party | 6 February 1943 – 24 July 1943 |
| Giuseppe Peverelli | | National Fascist Party | 24 July 1943 – 25 July 1943 |
| |
| Minister for the Lands freed by the Enemy | Giovanni Giuriati | | National Fascist Party | 31 October 1922 – 1 March 1923 |
| |
| Minister of the Air Force | Benito Mussolini (ad interim) | | National Fascist Party | 30 August 1925 – 12 September 1929 |
| Italo Balbo | | National Fascist Party | 12 September 1929 – 6 November 1933 |
| Benito Mussolini (ad interim) | | National Fascist Party | 6 November 1933 – 25 July 1943 |
| |
| Minister of Corporations | Benito Mussolini (ad interim) | | National Fascist Party | 2 July 1926 – 12 September 1929 |
| Giuseppe Bottai | | National Fascist Party | 12 September 1929 – 20 July 1932 |
| Benito Mussolini (ad interim) | | National Fascist Party | 20 July 1932 – 11 June 1936 |
| Ferruccio Lantini | | National Fascist Party | 11 June 1936 – 31 October 1939 |
| Renato Ricci | | National Fascist Party | 31 October 1939 – 6 February 1943 |
| Carlo Tiengo | | National Fascist Party | 6 February 1943 – 18 April 1943 |
| Tullio Cianetti | | National Fascist Party | 18 April 1943 – 25 July 1943 |
| |
| Minister of Agriculture and Forests | Giacomo Acerbo | | National Fascist Party | 12 September 1929 – 24 January 1935 |
| Edmondo Rossoni | | National Fascist Party | 24 January 1935 – 31 October 1939 |
| Giuseppe Tassinari | | National Fascist Party | 31 October 1939 – 26 December 1941 |
| Carlo Pareschi | | National Fascist Party | 26 December 1941 – 25 July 1943 |
| |
| Minister of Press and Propaganda | Galeazzo Ciano | | National Fascist Party | 26 June 1935 – 11 June 1936 |
| Dino Alfieri | | National Fascist Party | 11 June 1936 – 27 May 1937 |
| |
| Minister of Popular Culture | Dino Alfieri | | National Fascist Party | 27 May 1937 – 31 October 1939 |
| Alessandro Pavolini | | National Fascist Party | 31 October 1939 – 6 February 1943 |
| Gaetano Polverelli | | National Fascist Party | 6 February 1943 – 25 July 1943 |
| |
| Minister of the National Fascist Party | Achille Starace | | National Fascist Party | 11 January 1937 – 31 October 1939 |
| Ettore Muti | | National Fascist Party | 31 October 1939 – 30 October 1940 |
| Adelchi Serena | | National Fascist Party | 30 October 1940 – 26 December 1941 |
| Aldo Vidussoni | | National Fascist Party | 26 December 1941 – 19 April 1943 |
| Carlo Scorza | | National Fascist Party | 19 April 1943 – 25 July 1943 |
| |
| Minister for Exchanges and Currencies | Felice Guarneri | | National Fascist Party | 20 November 1937 – 31 October 1939 |
| Raffaello Riccardi | | National Fascist Party | 31 October 1939 – 6 February 1943 |
| Oreste Bonomi | | National Fascist Party | 6 February 1943 – 25 July 1943 |
| |
| Minister of War Production | Carlo Favagrossa | | National Fascist Party | 6 February 1943 – 25 July 1943 |
| |
| Secretary of the Council of Ministers | Giacomo Acerbo | | National Fascist Party | 31 October 1922 – 3 July 1924 |
| Giacomo Suardo | | National Fascist Party | 2 July 1924 – 21 December 1927 |
| Francesco Giunta | | National Fascist Party | 21 December 1927 – 20 July 1932 |
| Edmondo Rossoni | | National Fascist Party | 20 July 1932 – 24 January 1935 |
| Giacomo Medici Del Vascello | | National Fascist Party | 24 January 1935 – 31 October 1939 |
| Luigi Russo | | National Fascist Party | 31 October 1939 – 6 February 1943 |
| Amilcare Rossi | | National Fascist Party | 6 February 1943 – 25 July 1943 |