| Rank | Artist | Title |
| 1 | Jordin Sparks featuring Chris Brown | "No Air" from the album, Jordin Sparks |
| 2 | Flo Rida featuring T-Pain | "Low" from the album, Mail On Sunday and Step Up 2: The Streets soundtrack |
| 3 | Tiki Taane | "Always on My Mind"† from the album, Past, Present, Future |
| 4 | Chris Brown | "Forever" from the album, Exclusive: The Forever Edition |
| 5 | Chris Brown | "With You" from the album, Exclusive |
| 6 | Lady Gaga | "Poker Face" from the album, The Fame |
| 7 | Usher featuring Young Jeezy | "Love in This Club" from the album, Here I Stand |
| 8 | Leona Lewis | "Bleeding Love" from the album, Spirit |
| 9 | Katy Perry | "I Kissed a Girl" from the album, One Of The Boys |
| 10 | Nesian Mystik | "Nesian 101"† from the album, Elevator Musiq |
| 11 | P-Money featuring Vince Harder | "Everything"† from the album, Everything |
| 12 | Lady Gaga featuring Colby O'Donis | "Just Dance" from the album, The Fame |
| 13 | Kid Rock | "All Summer Long" from the album, Rock n Roll Jesus |
| 14 | Basshunter featuring DJ Mental Theo's Bazzheadz | "Now You're Gone" from the album, Now You're Gone – The Album |
| 15 | Kings of Leon | "Sex On Fire" from the album, Only By The Night |
| 16 | Rihanna | "Take a Bow" from the album, Good Girl Gone Bad: Reloaded |
| 17 | T.I. | "Whatever You Like" from the album, Paper Trail |
| 18 | Lil Wayne featuring Static Major | "Lollipop" from the album, Tha Carter III |
| 19 | P!nk | "So What" from the album, Funhouse |
| 20 | Ne-Yo | "Closer" from the album, Year Of The Gentleman |
| 21 | Rihanna | "Disturbia" from the album, Good Girl Gone Bad: Reloaded |
| 22 | Rihanna | "Don't Stop The Music" from the album, Good Girl Gone Bad |
| 23 | Phil Collins | "In the Air Tonight" from the album, Face Value |
| 24 | T.I. featuring Rihanna | "Live Your Life" from the album, Paper Trail |
| 25 | Katy Perry | "Hot n Cold" from the album, One Of The Boys |
| 26 | Opshop | "One Day"† from the album, Second Hand Planet |
| 27 | Beyoncé Knowles | "If I Were a Boy" from the album, I Am... Sasha Fierce |
| 28 | Britney Spears | "Piece of Me" from the album, Blackout |
| 29 | Pussycat Dolls | "When I Grow Up" from the album, Doll Domination |
| 30 | Duffy | "Mercy" from the album, Rockferry |
| 31 | Madonna featuring Justin Timberlake & Timbaland | "4 Minutes" from the album, Hard Candy |
| 32 | Soulja Boy featuring Arab | "Yahhh!" from the album, souljaboytellem.com |
| 33 | Three 6 Mafia Project Pat, Yung D & SuperPower | "Lolli Lolli (Pop That Body)" from the album, Last 2 Walk |
| 34 | The Veronicas | "Untouched" from the album, Hook Me Up |
| 35 | Estelle featuring Kanye West | "American Boy" from the album, Shine |
| 36 | Leona Lewis | "Better In Time" from the album, Spirit |
| 37 | Ne-Yo | "Miss Independent" from the album, Year Of The Gentleman |
| 38 | Jordin Sparks | "One Step at a Time" from the album, Jordin Sparks |
| 39 | Lil Mama featuring T-Pain and Chris Brown | "Shawty Get Loose" from the album, VYP: Voice Of The Young People |
| 40 | Metro Station | "Shake It" from the album, Metro Station |
| 41 | Keri Hilson | "Energy" from the album, In A Perfect World... |
| 42 | Flight of the Conchords | "The Distant Future"† from the extended play of the same name |
| 43 | Miley Cyrus | "See You Again" from the album, Hannah Montana 2: Meet Miley Cyrus |
| 44 | MGMT | "Electric Feel" from the album, Oracular Spectacular |
| 45 | Gabriella Cilmi | "Sweet About Me" from the album, Lessons To Be Learned |
| 46 | Chris Brown featuring Keri Hilson | "Superhuman" from the album, Exclusive: The Forever Edition |
| 47 | Usher | "Moving Mountains" from the album, Here I Stand |
| 48 | T-Pain | "Church" from the album, Epiphany |
| 49 | Soulja Boy | "Crank That" from the album, souljaboytellem.com |
| 50 | The Ting Tings | "That's Not My Name" from the album, We Started Nothing |