Trolnitrate Names IUPAC name 2-[bis(2-nitrooxyethyl)amino]ethyl nitrate
Identifiers ChemSpider ECHA InfoCard 100.027.615 UNII InChI=1S/C6H12N4O9/c11-8(12)17-4-1-7(2-5-18-9(13)14)3-6-19-10(15)16/h1-6H2
Y Key: HWKQNAWCHQMZHK-UHFFFAOYSA-N
Y C(CO[N+](=O)[O-])N(CCO[N+](=O)[O-])CCO[N+](=O)[O-]
Properties C6 H12 N4 O9 Molar mass 284.18 g/mol Pharmacology C01DA09 (WHO ) Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Trolnitrate (triethanolamine trinitrate , commonly used in the form of biphosphate salt also known as metamine) is an organic nitrate with vasodilator activity that is used to prevent or ameliorate attacks of angina pectoris.[ 1] Trolnitrate dilates the coronary vessels because of its basic action as a smooth muscle depressant, just as do nitroglycerin and other organic nitrates.[ 2]
References
Forms Targets
NO donors (prodrugs ) NONOates (diazeniumdiolates): Diethylamine/NO (DEA/NO) Diethylenetriamine/NO (DETA/NO) GLO/NO JS-K Methylamine hexamethylene methylamine/NO (MAHMA/NO) PROLI/NO Spermine/NO (SPER/NO) V-PYRRO/NO Unsorted: Cimlanod FK-409 FR144220 FR146881 N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide Enzyme (inhibitors )
NOS
nNOS iNOS 1-Amino-2-hydroxyguanidine 2-Ethylaminoguanidine 2-Iminopiperidine 1400W AEITU Aminoguanidine (pimagedine) AMT AR-C 102222 BYK-191023 Canavanine Cindunistat (SD-6010) EITU IPTU MITU N5 -(1-Iminoethyl)-L -ornithine (L -NIO) N6 -(1-Iminoethyl)-L -lysine (L -NIL) Nω -Methyl-L -arginine (L -NMA) Ronopterin (VAS-203) TRIM eNOS Unsorted
Arginase CAMK
Others Precursors: L -Arginine Nω -Hydroxy-L -arginine (NOHA) Indirect/downstream NO modulators: ACE inhibitors /AT-II receptor antagonists (e.g., captopril , losartan ) ETB receptor antagonists (e.g., bosentan ) L-Type calcium channel blockers (e.g., dihydropyridines : nifedipine ) Nebivolol (beta blocker ) PDE5 inhibitors (e.g., sildenafil ) non-selective PDE inhibitors (e.g., caffeine ) PDE9 inhibitors (e.g., paraxanthine ) cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil) Statins (e.g., simvastatin ) See also: Receptor/signaling modulators