List of Sites of Special Scientific Interest in Annandale and Eskdale
The following is a list of Sites of Special Scientific Interest in the Annandale and Eskdale Area of Search. For other areas, see List of SSSIs by Area of Search.
- Bell's Flow
 - Bigholms Burn
 - Castle Loch
 - Dryfe Water
 - Langholm - Newcastleton Hills
 - Loch Wood
 - Lochmaben Lochs
 - Moffat Hills
 - Penton Linns
 - Perchhall Loch
 - Raeburn Flow
 - River Esk, Glencartholm
 - River Tweed
 - Royal Ordnance Powfoot
 - Upper Solway Flats and Marshes