The 2010 Cal Poly Mustangs football team represented California Polytechnic State University, San Luis Obispo as member of the Great West Conference (GWC) during the 2010 NCAA Division I FCS football season. Led by second-year head coach Tim Walsh, Cal Poly compiled an overall record of 7–4 with a mark of 2–2 in conference play, placing third in the GWC. The Mustangs played home games at Alex G. Spanos Stadium in San Luis Obispo, California. 
 Schedule
 | Date | Time | Opponent | Rank | Site | Result | Attendance | 
|---|
| September 4 | 6:05 pm | Humboldt State*  | No. 25 |  | W 23–17 | 7,345 | 
 | September 11 | 6:05 pm | No. 1 Montana* | No. 18 | - Alex G. Spanos Stadium
 - San Luis Obispo, CA
 
  | W 35–33 | 8,027 | 
 | September 18 | 4:00 pm | at Texas State* | No. 17 |  | L 12–21 | 12,236 | 
 | September 25 | 5:00 pm | at No. 17 McNeese State* | No. 22 |  | W 40–14 | 11,958 | 
 | October 2 | 7:00 pm | at Fresno State* | No. 14 |  | L 17–38 | 37,069 | 
 | October 9 | 3:00 pm | at Old Dominion* | No. 16 |  | W 50–37 | 19,782 | 
 | October 16 | 2:00 pm | at Southern Utah | No. 13 |  | L 7–20 | 8,219 | 
 | October 23 | 6:05 pm | North Dakota | No. 23 | - Alex G. Spanos Stadium
 - San Luis Obispo, CA
 
  | W 22–21 | 10,220 | 
 | October 30 | 6:05 pm | St. Francis (PA)* | No. 20 | - Alex G. Spanos Stadium
 - San Luis Obispo, CA
 
  | W 41–33 | 7,132 | 
 | November 6 | 2:05 pm | at South Dakota | No. 18 |  | W 38–24 | 7,369 | 
 | November 13 | 6:05 pm | UC Davis | No. 18 |  | L 21–22 | 11,075 | 
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 [1][2][3] 
 Game summaries
     |   |    |    |    |   |  Total |  
  | Lumberjacks  |  7  |  10  |  0  |  0 |  17 |  
  | #25 Mustangs  |  0  |  7  |  14  |  2 |  23 |  
      |   |    |    |    |   |  Total |  
  | #1 Grizzlies  |  14  |  0  |  6  |  13 |  33 |  
  | Mustangs  |  7  |  7  |  14  |  7 |  35 |  
      |   |    |    |    |   |  Total |  
  | #18 Mustangs  |  3  |  0  |  9  |  0 |  12 |  
  | Cowboys  |  7  |  0  |  7  |  7 |  21 |  
      |   |    |    |    |   |  Total |  
  | Mustangs  |  3  |  21  |  16  |  0 |  40 |  
  | Cowboys  |  0  |  7  |  0  |  7 |  14 |  
   Fresno State outscored Cal Poly 17-0 in the second half in the first meeting between the two rivals since 1985. Bulldogs go to 8-0 vs. FCS/1-AA teams under Pat Hill. 
    |   |    |    |    |   |  Total |  
  | Mustangs  |  3  |  14  |  0  |  0 |  17 |  
  | Bulldogs  |  14  |  7  |  10  |  7 |  38 |  
      |   |    |    |    |   |  Total |  
  | Mustangs  |  17  |  10  |  0  |  23 |  50 |  
  | Monarchs  |  7  |  13  |  0  |  17 |  37 |  
      |   |    |    |    |   |  Total |  
  | Mustangs  |    |    |    |   |  0 |  
  | Thunderbirds  |    |    |    |   |  0 |  
         |   |    |    |    |   |  Total |  
  | Red Flash  |  6  |  6  |  7  |  14 |  33 |  
  | Mustangs  |  7  |  6  |  14  |  14 |  41 |  
      |   |    |    |    |   |  Total |  
  | Mustangs  |    |    |    |   |  0 |  
  | Coyotes  |    |    |    |   |  0 |  
       |   |    |    |    |   |  Total |  
  | Aggies  |    |    |    |   |  0 |  
  | Mustangs  |    |    |    |   |  0 |  
  References
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National championship seasons in bold  |