| No. | Minister | Party | Term | President |
| Ministry of Foreign Affairs of the Province of Buenos Aires (1822–1826) |
| – | Bernardino Rivadavia | | Unitarian Party | 5 February 1822 – 24 May 1824 | | Government Junta |
| – | Manuel José García | | Independent | 24 May 1824 – 10 February 1826 |
| Ministry of Foreign Affairs of the United Provinces of the Río de la Plata (1826–1831) |
| – | Francisco F. de la Cruz | | Unitarian Party | 10 February 1826 – 27 June 1827 | | Bernardino Rivadavia |
| – | Manuel Dorrego | | Federalist Party | 13 August 1827 – 1 December 1828 | | Vicente López y Planes |
| Ministry of Foreign Affairs (1853–1898) |
| 1 | Juan María Gutiérrez | | Independent | 5 March 1854 – 1 August 1856 | | Justo José de Urquiza |
| 2 | Bernabé López | | Unitarian Party | 1 August 1856 – 30 September 1858 |
| 3 | Luis José de la Peña | | Independent | 30 September 1858 – 5 March 1860 |
| 4 | Emilio de Alvear | | Independent | 5 March 1860 – 14 December 1860 | | Santiago Derqui |
| 5 | Francisco Pico Jr. | | Unitarian Party | 14 December 1860 – 6 February 1861 |
| 5 | Nicanor Molinas | | Independent | 6 February 1861 – 3 July 1861 |
| 6 | José Severo de Olmos | | Independent | 3 July 1861 – 5 November 1861 |
| 7 | Rufino de Elizalde | | Nationalist Party | 12 October 1862 – 6 December 1867 | | Bartolomé Mitre |
| 8 | Marcelino Ugarte | | Nationalist Party | 6 December 1867 – 25 January 1868 |
| 9 | Rufino de Elizalde | | Nationalist Party | 25 January 1868 – 12 October 1868 |
| 10 | Mariano Varela | | Independent | 12 October 1868 – 17 August 1870 | | Domingo Sarmiento |
| 11 | Carlos Tejedor | | Independent | 17 August 1870 – 12 October 1874 |
| 12 | Pedro A. Pardo | | Independent | 12 October 1874 – 2 August 1875 | | Nicolás Avellaneda |
| 13 | Bernardo de Irigoyen | | National Autonomist Party | 2 August 1875 – 2 October 1877 |
| 14 | Rufino de Elizalde | | National Autonomist Party | 2 October 1877 – 8 May 1878 |
| 15 | Manuel Montes de Oca | | Independent | 8 May 1878 – 6 September 1879 |
| 16 | Domingo Sarmiento | | Independent | 6 September 1879 – 9 October 1879 |
| 17 | Lucas González | | Independent | 9 October 1879 – 7 June 1880 |
| 18 | Benjamín Zorrilla | | National Autonomist Party | 7 June 1880 – 12 October 1880 |
| 19 | Bernardo de Irigoyen | | National Autonomist Party | 12 October 1880 – 11 February 1882 | | Julio Argentino Roca |
| 20 | Victorino de la Plaza | | National Autonomist Party | 11 February 1882 – 25 October 1883 |
| 21 | Francisco J. Ortíz | | National Autonomist Party | 25 October 1883 – 12 October 1886 |
| 22 | Norberto Quirno Costa | | National Autonomist Party | 12 October 1886 – 27 August 1889 | | Miguel Juárez Celman |
| 23 | Estanislao Zeballos | | National Autonomist Party | 10 September 1889 – 12 April 1890 |
| 24 | Roque Sáenz Peña | | National Autonomist Party | 12 April 1890 – 6 August 1890 |
| 25 | Eduardo Costa | | National Autonomist Party | 7 August 1890 – 22 October 1891 | | Carlos Pellegrini |
| 26 | Estanislao Zeballos | | National Autonomist Party | 22 October 1891 – 12 October 1892 |
| 27 | Tomás S. de Anchorena | | National Autonomist Party | 12 October 1892 – 1 May 1893 | | Luis Sáenz Peña |
| 28 | Amancio Alcorta | | National Autonomist Party | 1 May 1893 – 7 June 1893 |
| 29 | Miguel Cané | | National Autonomist Party | 7 June 1893 – 27 June 1893 |
| 30 | Norberto Quirno Costa | | National Autonomist Party | 27 June 1893 – 5 July 1893 |
| 33 | Valentín Virasoro | | National Autonomist Party | 5 July 1893 – 16 December 1893 |
| 34 | Eduardo Costa | | National Autonomist Party | 16 December 1893 – 23 January 1895 |
| 35 | Amancio Alcorta | | National Autonomist Party | 23 January 1895 – 12 October 1898 | | José Evaristo Uriburu |
| Ministry of Foreign Affairs and Worship (1898–1993) |
| 35 | Amancio Alcorta | | National Autonomist Party |
| 12 October 1898 – 21 January 1899 | | Julio Argentino Roca |
| 36 | Felipe Yofre | | National Autonomist Party | 21 January 1899 – 7 May 1902 |
| 37 | Luis María Drago | | National Autonomist Party | 9 May 1902 – 18 July 1903 |
| 38 | José A. Terry | | National Autonomist Party | 20 July 1903 – 12 October 1904 |
| 39 | Carlos Rodríguez Larreta | | National Autonomist Party | 12 October 1904 – 12 March 1906 | | Manuel Quintana |
| 40 | Manuel Montes de Oca | | National Autonomist Party | 12 March 1906 – 21 November 1906 | | José Figueroa Alcorta |
| 41 | Estanislao Zeballos | | National Autonomist Party | 21 November 1906 – 21 June 1908 |
| 42 | Victorino de la Plaza | | National Autonomist Party | 22 June 1908 – 9 August 1910 |
| 43 | Carlos Rodríguez Larreta | | National Autonomist Party | 9 August 1910 – 12 October 1910 |
| 44 | Epifanio Portela | | National Autonomist Party | 12 October 1910 – 17 December 1910 | | Roque Sáenz Peña |
| 45 | Ernesto Bosch | | Independent | 17 December 1910 – 16 February 1914 |
| 46 | José Luis Murature | | National Autonomist Party | 16 February 1914 – 9 August 1914 |
| 9 August 1914 – 12 October 1916 | | Victorino de la Plaza |
| 48 | Carlos Becú | | Radical Civic Union | 12 October 1916 – 30 January 1917 | | Hipólito Yrigoyen |
| 49 | Honorio Pueyrredón | | Radical Civic Union | 30 January 1917 – 12 October 1922 |
| 50 | Ángel Gallardo | | Radical Civic Union | 12 October 1922 – 12 October 1928 | | Marcelo T. de Alvear |
| 51 | Horacio Oyhanarte | | Radical Civic Union | 12 October 1928 – 6 September 1930 | | Hipólito Yrigoyen |
| 52 | Ernesto Bosch | | Independent | 6 September 1930 – 9 October 1931 | | José Félix Uriburu |
| 53 | Adolfo Bioy Domecq | | Independent | 9 October 1931 – 20 February 1932 |
| 54 | Carlos Saavedra Lamas | | National Democratic Party | 20 February 1932 – 20 February 1938 | | Agustín Pedro Justo |
| 55 | José María Cantilo | | Radical Civic Union | 20 February 1938 – 2 September 1940 | | Roberto M. Ortiz |
| 56 | Julio A. Pascual Roca | | National Democratic Party | 20 February 1938 – 2 September 1940 |
| 57 | Guillermo Rothe | | National Democratic Party | 28 January 1941 – 13 June 1941 |
| 58 | Enrique Ruiz Guiñazú | | Independent | 13 June 1941 – 27 June 1942 |
| 27 June 1942 – 4 June 1943 | | Ramón Castillo |
| 59 | Segundo Storni | | Independent (Military) | 7 June 1943 – 9 September 1943 | | Pedro Pablo Ramírez |
| 60 | Alberto Gilbert | | Independent (Military) | 10 September 1943 – 21 October 1943 |
| 61 | Diego I. Mason | | Independent (Military) | 22 February 1944 – 2 May 1944 | | Edelmiro Farrell |
| 62 | Orlando L. Peluffo | | Independent (Military) | 2 May 1944 – 15 January 1945 |
| 63 | César Ameghino | | Independent | 18 January 1945 – 27 August 1945 |
| 64 | Juan Isaac Cooke | | Radical Civic Union | 27 August 1945 – 4 June 1946 |
| 65 | Juan Atilio Bramuglia | | Peronist Party | 4 June 1946 – 11 August 1949 | | Juan Domingo Perón |
| 66 | Hipólito Jesús Paz | | Peronist Party | 13 August 1949 – 28 June 1951 |
| 67 | Jerónimo Remorino | | Peronist Party | 28 June 1951 – 25 August 1955 |
| 68 | Ildefonso Cavagna Martínez | | Peronist Party | 25 August 1955 – 22 September 1955 |
| 69 | Mario Amadeo | | Independent | 22 September 1955 – 13 November 1955 | | Eduardo Lonardi |
| 70 | Luis Podestá Costa | | Independent | 13 November 1955 – 25 January 1957 | | Pedro Eugenio Aramburu |
| 71 | Alfonso de Laferrère | | Independent | 30 January 1957 – 13 January 1958 |
| 72 | Alejandro Ceballos | | Independent | 29 January 1958 – 1 May 1958 |
| 73 | Carlos Florit | | Radical Civic Union | 1 May 1958 – 15 May 1959 | | Arturo Frondizi |
| 74 | Diógenes Taboada | | Radical Civic Union | 22 May 1959 – 28 April 1961 |
| 75 | Adolfo Mugica | | National Democratic Party | 28 April 1961 – 29 August 1961 |
| 76 | Miguel Ángel Cárcano | | Radical Civic Union | 29 August 1961 – 12 September 1961 |
| 77 | Roberto Etchepareborda | | Radical Civic Union | 12 September 1961 – 29 March 1962 |
| 29 March 1962 – 5 April 1962 | | José María Guido |
| 78 | Mariano José Drago | | Independent | 5 April 1962 – 30 April 1962 |
| 79 | Bonifacio del Carril | | Independent | 30 April 1962 – 5 October 1962 |
| 80 | Carlos Manuel Muñiz | | Independent | 5 October 1962 – 14 May 1963 |
| 81 | Juan Carlos Cordini | | Independent | 14 May 1963 – 12 October 1963 |
| 82 | Miguel Ángel Zavala Ortiz | | Radical Civic Union | 12 October 1963 – 28 June 1966 | | Arturo Illia |
| 83 | Nicanor Costa Méndez | | Independent | 28 June 1966 – 16 June 1969 | | Juan Carlos Onganía |
| 84 | Juan B. Martín | | Independent | 16 June 1969 – 18 June 1970 |
| 85 | Luis M. de Pablo Pardo | | Independent | 18 June 1970 – 22 March 1971 | | Roberto M. Levingston |
| 22 March 1971 – 22 June 1972 | | Alejandro Lanusse |
| 86 | Eduardo Mc Loughlin | | Independent (Military) | 22 June 1972 – 25 May 1973 |
| 87 | Juan Carlos Puig | | Justicialist Party | 25 May 1973 – 13 July 1973 | | Héctor Cámpora |
| 88 | Alberto Vignes | | Justicialist Party | 13 July 1973 – 12 October 1973 | | Raúl Lastiri |
| 12 October 1973 – 1 July 1974 | | Juan Domingo Perón |
| 1 July 1974 – 11 August 1975 | | Isabel Perón |
| 89 | Ángel Federico Robledo | | Justicialist Party | 11 August 1975 – 16 September 1975 |
| 90 | Manuel Aráuz Castex | | Justicialist Party | 16 September 1975 – 14 January 1976 |
| 91 | Raúl Alberto Quijano | | Justicialist Party | 14 January 1976 – 24 March 1976 |
| 92 | César Augusto Guzzetti | | Independent (Military) | 24 March 1976 – 23 May 1977 | | Jorge Rafael Videla |
| 93 | Oscar Antonio Montes | | Independent (Military) | 23 May 1977 – 27 October 1978 |
| 94 | Carlos Washington Pastor | | Independent (Military) | 5 November 1978 – 29 March 1981 |
| 95 | Oscar Camilión | | MID | 29 March 1981 – 12 December 1981 | | Roberto Viola |
| 96 | Norberto Couto | | Independent (Military) | 12 December 1981 – 22 December 1981 | | Carlos Lacoste |
| 97 | Nicanor Costa Méndez | | Independent | 22 December 1981 – 2 July 1982 | | Leopoldo Galtieri |
| 98 | Juan R. Aguirre Lanari | | Corrientes Liberal Party | 2 July 1982 – 10 December 1983 | | Reynaldo Bignone |
| 99 | Dante Caputo | | Radical Civic Union | 10 December 1983 – 26 May 1989 | | Raúl Alfonsín |
| 100 | Susana Ruiz Cerutti | | Radical Civic Union | 26 May 1989 – 8 July 1989 |
| 101 | Domingo Cavallo | | Justicialist Party | 8 July 1989 – 31 January 1991 | | Carlos Menem |
| 102 | Guido di Tella | | Justicialist Party | 31 January 1991 – 13 January 1993 |
| Ministry of Foreign Affairs, International Trade and Worship (1993–2010) |
| 102 | Guido di Tella | | Justicialist Party | 13 January 1993 – 10 December 1999 | | Carlos Menem |
| 103 | Adalberto Rodríguez Giavarini | | Radical Civic Union | 10 December 1999 – 21 December 2001 | | Fernando de la Rúa |
| 21 December 2001 – 23 December 2001 | | Ramón Puerta |
| 104 | José María Vernet | | Justicialist Party | 23 December 2001 – 3 January 2002 | | Adolfo Rodríguez Saá |
| 105 | Carlos Ruckauf | | Justicialist Party | 3 January 2002 – 25 May 2003 | | Eduardo Duhalde |
| 106 | Rafael Bielsa | | Justicialist Party | 25 May 2003 – 3 December 2005 | | Néstor Kirchner |
| 107 | Jorge Taiana | | Justicialist Party | 3 December 2005 – 10 December 2007 |
| 10 December 2007 – 18 June 2010 | | Cristina Fernández de Kirchner |
| Ministry of Foreign Affairs and Worship (2010–2019) |
| 108 | Héctor Timerman | | Justicialist Party | 18 June 2010 – 10 December 2015 | | Cristina Fernández de Kirchner |
| 109 | Susana Malcorra | | Radical Civic Union | 10 December 2015 – 12 June 2017 | | Mauricio Macri |
| 110 | Jorge Faurie | | Independent | 12 June 2017 – 10 December 2019 |
| Ministry of Foreign Affairs, International Trade and Worship (2019–present) |
| 111 | Felipe Solá | | Justicialist Party | 10 December 2019 – 20 September 2021 | | Alberto Fernández |
| 112 | Santiago Cafiero | | Justicialist Party | 20 September 2021 – 10 December 2023 |
| 113 | Diana Mondino | | Independent | 10 December 2023 – 30 October 2024 | | Javier Milei |
| 114 | Gerardo Werthein | | Independent | 30 October 2024 – Present |