5F-NNE1

5F-NNE1
Legal status
Legal status	CA: Schedule II; DE: NpSG (Industrial and scientific use only); UK: Class B;
Identifiers
	IUPAC name 1-(5-Fluoropentyl)-N-(naphthalen-1-yl)-1H-indole-3-carboxamide;
CAS Number	1445580-60-8;
PubChem CID	118796566;
ChemSpider	29341632;
UNII	3T22QDP4D9;
CompTox Dashboard (EPA)	DTXSID901032710 ;
Chemical and physical data
Formula	C24H23FN2O
Molar mass	374.459 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FCCCCCn1cc(c2c1cccc2)C(=O)Nc1cccc2c1cccc2;
	InChI InChI=1S/C24H23FN2O/c25-15-6-1-7-16-27-17-21(20-12-4-5-14-23(20)27)24(28)26-22-13-8-10-18-9-2-3-11-19(18)22/h2-5,8-14,17H,1,6-7,15-16H2,(H,26,28); Key:DJKVOBZLMBHFKX-UHFFFAOYSA-N;

5F-NNE1 (also known as 5F-NNEI and 5F-MN-24) is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB₁ receptor and has been sold online as a designer drug.^[1]^[2] Given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, it is suspected that metabolic hydrolysis of the amide group of 5F-NNE1 may release 1-naphthylamine, a known carcinogen.

Legality

Sweden's public health agency suggested classifying 5F-NNE1 as hazardous substance on November 10, 2014.^[3]

References

^ "5F-NNEI". Southern Association of Forensic Scientists. Archived from the original on 27 May 2015. Retrieved 24 July 2015.
^ Wohlfarth A, Castaneto MS, Zhu M, Pang S, Scheidweiler KB, Kronstrand R, Huestis MA (May 2015). "Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACA". The AAPS Journal. 17 (3): 660–77. doi:10.1208/s12248-015-9721-0. PMC 4406957. PMID 25721194.
^ "Cannabinoider föreslås bli klassade som hälsofarlig vara". Folkhälsomyndigheten. Retrieved 24 July 2015.

[1] "5F-NNEI". Southern Association of Forensic Scientists. Archived from the original on 27 May 2015. Retrieved 24 July 2015.

[2] Wohlfarth A, Castaneto MS, Zhu M, Pang S, Scheidweiler KB, Kronstrand R, Huestis MA (May 2015). "Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACA". The AAPS Journal. 17 (3): 660–77. doi:10.1208/s12248-015-9721-0. PMC 4406957. PMID 25721194.

[3] "Cannabinoider föreslås bli klassade som hälsofarlig vara". Folkhälsomyndigheten. Retrieved 24 July 2015.

[1]

[2]

[3]

Legality

See also

References