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 | α1 | | Agonists |  | 
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 | Antagonists |  AbanoquilAjmalicineAlfuzosinAnisodamineAnisodineAtiprosinAtypical antipsychotics (e.g., brexpiprazole, clozapine, olanzapine, quetiapine, risperidone)BenoxathianBeta blockers (e.g., adimolol, amosulalol, arotinolol, carvedilol, eugenodilol, labetalol)BuflomedilBunazosinCorynanthineDapiprazoleDomesticineDoxazosinErgolines (e.g., acetergamine, ergotamine, dihydroergotamine, lisuride, nicergoline, terguride)EtoperidoneFenspirideHydroxyzineIndoraminKetanserinL-765,314mCPPMepiprazoleMetazosinMonatepilMoxisylyteNaftopidilNantenineNeldazosinNiaprazineNiguldipinePardoprunoxPelanserinPerlapinePhendioxanPhenoxybenzaminePhentolaminePhenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione)PiperoxanPrazosinQuinazosinQuinidineSilodosinSpegatrineSpiperoneTalipexoleTamsulosinTerazosinTiodazosinTolazolineTetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin)Tricyclic antidepressants (e.g., amitriptyline, clomipramine, doxepin, imipramine, trimipramine)TrimazosinTypical antipsychotics (e.g., chlorpromazine, fluphenazine, loxapine, thioridazine)UrapidilWB-4101Zolertine
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 | α2 | | Agonists |  | 
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 | Antagonists |  1-PPAdimololAmesergideAptazapineAtipamezoleAtypical antipsychotics (e.g., asenapine, brexpiprazole, clozapine, lurasidone, olanzapine, paliperidone, quetiapine, risperidone, zotepine)Azapirones (e.g., buspirone, gepirone, ipsapirone, tandospirone)BRL-44408BuflomedilCirazolineEfaroxanEsmirtazapineFenmetozoleFluparoxanIdazoxanKetanserinLisuridemCPPMianserinMirtazapineNAN-190PardoprunoxPhentolaminePhenoxybenzaminePiperoxanPiribedilRauwolscineRotigotineSetiptilineSpegatrineSpiroxatrineSunepitronTergurideTolazolineTypical antipsychotics (e.g., chlorpromazine, fluphenazine, loxapine, thioridazine)Yohimbine
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 | β |  | 
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 |  See also: Receptor/signaling modulatorsDopaminergicsSerotonergicsMonoamine reuptake inhibitorsMonoamine releasing agentsMonoamine metabolism modulatorsMonoamine neurotoxins
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 | D1-like |  | 
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 | D2-like |  | 
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 |  See also: Receptor/signaling modulatorsAdrenergicsSerotonergicsMonoamine reuptake inhibitorsMonoamine releasing agentsMonoamine metabolism modulatorsMonoamine neurotoxins
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|  | 
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 | H1 | | Agonists |  | 
|---|
 | Antagonists |    Others: Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, brilaroxazine, clozapine, iloperidone, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone, zotepine)Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione)Tetracyclic antidepressants (e.g., amoxapine, loxapine, maprotiline, mianserin, mirtazapine, oxaprotiline)Tricyclic antidepressants (e.g., amitriptyline, butriptyline, clomipramine, desipramine, dosulepin (dothiepin), doxepin, imipramine, iprindole, lofepramine, nortriptyline, protriptyline, trimipramine)Typical antipsychotics (e.g., chlorpromazine, flupenthixol, fluphenazine, loxapine, perphenazine, prochlorperazine, thioridazine, thiothixene)
 Unknown/unsorted: AzanatorBelarizineElbanizineFlotrenizineGSK1004723NapactadineTagorizineTrelnarizineTrenizine
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 | H2 |  | 
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 | H3 |  | 
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 | H4 |  | 
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 |  See alsoReceptor/signaling modulatorsMonoamine metabolism modulatorsMonoamine reuptake inhibitors
 | 
|  | 
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 | MT1Tooltip Melatonin receptor 1 |  | 
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 | MT2Tooltip Melatonin receptor 2 |  | 
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 | Unsorted |  Agonists: 2-Phenylmelatonin5-Methoxyluzindole6-Chloromelatonin6-Fluoromelatonin6-Methoxymelatonin6,7-Dichloro-2-methylmelatonin8-M-PDOTAMMTCGR-135,531 (of MT3Tooltip melatonin receptor 1C)N-AcetyltryptamineN-ButanoylmelatoninN-PropionylmelatoninS-24268S-25150
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 |  See also: Receptor/signaling modulatorsAdrenergicsDopaminergicsSerotonergicsMonoamine metabolism modulators
 | 
|  | 
|---|
 | 5-HT1 | | 5-HT1A | |  Agonists: 8-OH-DPATAdatanserinAmphetamineAntidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine)Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, lurasidone, quetiapine, ziprasidone)Azapirones (e.g., buspirone, eptapirone, gepirone, perospirone, tandospirone)Bay R 1531BefiradolBMY-14802CannabidiolDimemebfeDopamineEbalzotanEltoprazineEnciprazineErgolines (e.g., bromocriptine, cabergoline, dihydroergotamine, ergotamine, lisuride, LSD, methylergometrine (methylergonovine), methysergide, pergolide)F-11461F-12826F-13714F-14679F-15063F-15599FlesinoxanFlibanserinFlumexadolHypidoneLesopitronLY-293284LY-301317mCPPMKC-242NaluzotanNBUMPOsemozotanOxaflozanePardoprunoxPiclozotanRauwolscineRepinotanRoxindoleRU-24969S-14506S-14671S-15535SarizotanSerotonin (5-HT)SSR-181507SunepitronTryptamines (e.g., 5-CT, 5-MeO-DMT, 5-MT, bufotenin, DMT, indorenate, N-Me-5-HT, psilocin, psilocybin)TGBA01ADU-92016-AUrapidilVilazodoneXaliprodenYohimbine
 |  |  Positive allosteric modulators: Oleamide
 |  |  Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole)AV965Beta blockers (e.g., alprenolol, carteolol, cyanopindolol, iodocyanopindolol, isamoltane, oxprenolol, penbutolol, pindobind, pindolol, propranolol, tertatolol)BMY-7378CSP-2503DotarizineErgolines (e.g., metergoline)FCE-24379FlopropioneGR-46611IsamoltaneLecozotanMefwayMetitepine (methiothepin)MIN-117 (WF-516)MPPFNAN-190RobalzotanS-15535SB-649915SDZ 216-525SpiperoneSpiramideSpiroxatrineUH-301WAY-100135WAY-100635Xylamidine
 |  |  | 
 | 
|---|
 | 5-HT1B | |  Agonists: AnpirtolineCGS-12066ACP-93129CP-94253CP-122288CP-135807EltoprazineErgolines (e.g., bromocriptine, dihydroergotamine, ergotamine, methylergometrine (methylergonovine), methysergide, pergolide)mCPPRU-24969Serotonin (5-HT)Triptans (e.g., avitriptan, donitriptan, eletriptan, sumatriptan, zolmitriptan)TFMPPTryptamines (e.g., 5-BT, 5-CT, 5-MT, DMT)Vortioxetine
 |  |  |  |  | 
 | 
|---|
 | 5-HT1D | |  Agonists: CP-122288CP-135807CP-286601Ergolines (e.g., bromocriptine, cabergoline, dihydroergotamine, ergotamine, LSD, methysergide)GR-46611L-694247L-772405mCPPPNU-109291PNU-142633Serotonin (5-HT)TGBA01ADTriptans (e.g., almotriptan, avitriptan, donitriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan)Tryptamines (e.g., 5-BT, 5-CT, 5-Et-DMT, 5-MT, 5-(nonyloxy)tryptamine, DMT)
 |  |  |  |  | 
 | 
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 | 5-HT1E |  | 
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 | 5-HT1F |  | 
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 | 
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 | 5-HT2 | | 5-HT2A | |  Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe, 25CN-NBOH, 2CBFly-NBOMe)2Cs (e.g., 2C-B, 2C-E, 2C-I, 2C-T-2, 2C-T-7, 2C-T-21)2C-B-FLY2CB-Ind5-Methoxytryptamines (5-MeO-DET, 5-MeO-DiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MT)α-Alkyltryptamines (e.g., 5-Cl-αMT, 5-Fl-αMT, 5-MeO-αET, 5-MeO-αMT, α-Me-5-HT, αET, αMT)AL-34662AL-37350ABromo-DragonFLYDimemebfeDMBMPPDOx (e.g., DOB, DOC, DOI, DOM)EfavirenzErgolines (e.g., 1P-LSD, ALD-52, bromocriptine, cabergoline, ergine (LSA), ergometrine (ergonovine), ergotamine, lisuride, LA-SS-Az, LSB, LSD, LSD-Pip, LSH, LSP, methylergometrine (methylergonovine), pergolide)FlumexadolIHCH-7113JimscalineLorcaserinMDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)O-4310OxaflozanePHA-57378PNU-22394PNU-181731RH-34SCHEMBL5334361Phenethylamines (e.g., lophophine, mescaline)Piperazines (e.g., BZP, quipazine, TFMPP)Serotonin (5-HT)TCB-2TFMFlyTryptamines (e.g., 5-BT, 5-CT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)
 |  |  |  |  Antagonists: 5-I-R911505-MeO-NBpBrTAC-90179AdatanserinAltanserinAntihistamines (e.g., cyproheptadine, hydroxyzine, ketotifen, perlapine)AMDAAtypical antipsychotics (e.g., amperozide, aripiprazole, asenapine, blonanserin, brexpiprazole, carpipramine, clocapramine, clorotepine, clozapine, fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine, ziprasidone, zotepine)ChlorprothixeneCinanserinCSP-2503DeramciclaneDotarizineEplivanserinErgolines (e.g., amesergide, LY-53857, LY-215840, mesulergine, metergoline, methysergide, sergolexole)FananserinFlibanserinGlemanserinIrindaloneKetanserinKML-010LandipirdineLY-393558mCPPMedifoxamineMetitepine (methiothepin)MIN-117 (WF-516)NaftidrofurylNantenineNelotanserinOpiranserin (VVZ-149)PelanserinPhenoxybenzaminePimavanserinPirenperonePizotifenPruvanserinRauwolscineRitanserinRoluperidoneS-14671SarpogrelateSerotonin antagonists and reuptake inhibitors (e.g., etoperidone, hydroxynefazodone, lubazodone, mepiprazole, nefazodone, triazoledione, trazodone)SR-46349BTGBA01ADTeniloxazineTemanogrelTetracyclic antidepressants (e.g., amoxapine, aptazapine, esmirtazapine, maprotiline, mianserin, mirtazapine)Tricyclic antidepressants (e.g., amitriptyline)Typical antipsychotics (e.g., chlorpromazine, fluphenazine, haloperidol, loxapine, perphenazine, pimozide, pipamperone, prochlorperazine, setoperone, spiperone, spiramide, thioridazine, thiothixene, trifluoperazine)VolinanserinXylamidineYohimbine
 |  |  | 
 | 
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 | 5-HT2B | |  Agonists: 4-MethylaminorexAminorexAmphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine)BW-723C86DOx (e.g., DOB, DOC, DOI, DOM)Ergolines (e.g., cabergoline, dihydroergocryptine, dihydroergotamine, ergotamine, methylergometrine (methylergonovine), methysergide, pergolide)LorcaserinMDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)Piperazines (e.g., TFMPP)PNU-22394Ro60-0175Serotonin (5-HT)Tryptamines (e.g., 5-BT, 5-CT, 5-MT, α-Me-5-HT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)
 |  |  Antagonists: AgomelatineAtypical antipsychotics (e.g., amisulpride, aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, N-desalkylquetiapine (norquetiapine), N-desmethylclozapine (norclozapine), olanzapine, pipamperone, quetiapine, risperidone, ziprasidone)CyproheptadineEGIS-7625Ergolines (e.g., amesergide, bromocriptine, lisuride, LY-53857, LY-272015, mesulergine)KetanserinLY-393558mCPPMetadoxineMetitepine (methiothepin)PirenperonePizotifenPropranololPRX-08066RauwolscineRitanserinRS-127445SarpogrelateSB-200646SB-204741SB-206553SB-215505SB-221284SB-228357SDZ SER-082TegaserodTetracyclic antidepressants (e.g., amoxapine, mianserin, mirtazapine)TrazodoneTypical antipsychotics (e.g., chlorpromazine)TIK-301Yohimbine
 |  |  | 
 | 
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 | 5-HT2C | |  Agonists: 2Cs (e.g., 2C-B, 2C-E, 2C-I, 2C-T-2, 2C-T-7, 2C-T-21)5-Methoxytryptamines (5-MeO-DET, 5-MeO-DiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MT)α-Alkyltryptamines (e.g., 5-Cl-αMT, 5-Fl-αMT, 5-MeO-αET, 5-MeO-αMT, α-Me-5-HT, αET, αMT)A-372159AL-38022AAlstonineCP-809101DimemebfeDOx (e.g., DOB, DOC, DOI, DOM)Ergolines (e.g., ALD-52, cabergoline, dihydroergotamine, ergine (LSA), ergotamine, lisuride, LA-SS-Az, LSB, LSD, LSD-Pip, LSH, LSP, pergolide)FlumexadolLorcaserinMDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)MK-212ORG-12962ORG-37684OxaflozanePHA-57378Phenethylamines (e.g., lophophine, mescaline)Piperazines (e.g., aripiprazole, BZP, mCPP, quipazine, TFMPP)PNU-22394PNU-181731Ro60-0175Ro60-0213Serotonin (5-HT)Tryptamines (e.g., 5-BT, 5-CT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)VabicaserinWAY-629WAY-161503YM-348
 |  |  |  |  Antagonists: AdatanserinAgomelatineAtypical antipsychotics (e.g., asenapine, clorotepine, clozapine, fluperlapine, iloperidone, melperone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, ziprasidone, zotepine)CaptodiameCEPCCinanserinCyproheptadineDeramciclaneDesmetramadolDotarizineEltoprazineErgolines (e.g., amesergide, bromocriptine, LY-53857, LY-215840, mesulergine, metergoline, methysergide, sergolexole)EtoperidoneFluoxetineFR-260010IrindaloneKetanserinKetotifenLatrepirdine (dimebolin)MedifoxamineMetitepine (methiothepin)NefazodonePirenperonePizotifenPropranololRitanserinRS-102221S-14671SB-200646SB-206553SB-221284SB-228357SB-242084SB-243213SDZ SER-082TedatioxetineTetracyclic antidepressants (e.g., amoxapine, aptazapine, esmirtazapine, maprotiline, mianserin, mirtazapine)TIK-301TramadolTrazodoneTricyclic antidepressants (e.g., amitriptyline, nortriptyline)Typical antipsychotics (e.g., chlorpromazine, loxapine, pimozide, pipamperone, thioridazine)Xylamidine
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 | 5-HT3–7 | | 5-HT3 | |  Agonists: Alcohols (e.g., butanol, ethanol (alcohol), trichloroethanol)m-CPBGPhenylbiguanidePiperazines (e.g., BZP, mCPP, quipazine)RS-56812Serotonin (5-HT)SR-57227SR-57227ATryptamines (e.g., 2-Me-5-HT, 5-CT, bufotenidine (5-HTQ))Volatiles/gases (e.g., halothane, isoflurane, toluene, trichloroethane)YM-31636
 |  |  |  |  Antagonists: AlosetronAnpirtolineArazasetronAS-8112Atypical antipsychotics (e.g., clozapine, olanzapine, quetiapine)AzasetronBatanoprideBemesetron (MDL-72222)CilansetronCSP-2503DazoprideDolasetronGalanolactoneGranisetronLerisetronMemantineOndansetronPalonosetronRamosetronRenzaprideRicasetronTedatioxetineTetracyclic antidepressants (e.g., amoxapine, mianserin, mirtazapine)ThujoneTropanserinTropisetronTypical antipsychotics (e.g., loxapine)Volatiles/gases (e.g., nitrous oxide, sevoflurane, xenon)VortioxetineZacoprideZatosetron
 |  |  |  |  | 
 | 
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 | 5-HT4 |  | 
|---|
 | 5-HT5A |  | 
|---|
 | 5-HT6 | |  Agonists: Ergolines (e.g., dihydroergocryptine, dihydroergotamine, ergotamine, lisuride, LSD, mesulergine, metergoline, methysergide)HypidoneSerotonin (5-HT)Tryptamines (e.g., 2-Me-5-HT, 5-BT, 5-CT, 5-MT, Bufotenin, E-6801, E-6837, EMD-386088, EMDT, LY-586713, N-Me-5-HT, ST-1936, tryptamine)WAY-181187WAY-208466
 |  |  Antagonists: ABT-354Atypical antipsychotics (e.g., aripiprazole, asenapine, clorotepine, clozapine, fluperlapine, iloperidone, olanzapine, tiospirone)AVN-101AVN-211AVN-322AVN-397BGC20-760BVT-5182BVT-74316CerlapirdineEGIS-12233GW-742457IdalopirdineKetanserinLandipirdineLatrepirdine (dimebolin)MasupirdineMetitepine (methiothepin)MS-245PRX-07034RitanserinRo 04-6790Ro 63-0563SB-258585SB-271046SB-357134SB-399885SB-742457Tetracyclic antidepressants (e.g., amoxapine, mianserin)Tricyclic antidepressants (e.g., amitriptyline, clomipramine, doxepin, nortriptyline)Typical antipsychotics (e.g., chlorpromazine, loxapine)
 |  |  | 
 | 
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 | 5-HT7 | |  |  |  Antagonists: Atypical antipsychotics (e.g., amisulpride, aripiprazole, asenapine, brexpiprazole, clorotepine, clozapine, fluperlapine, olanzapine, risperidone, sertindole, tiospirone, ziprasidone, zotepine)ButaclamolDR-4485EGIS-12233Ergolines (e.g., 2-Br-LSD (BOL-148), amesergide, bromocriptine, cabergoline, dihydroergotamine, ergotamine, LY-53857, LY-215840, mesulergine, metergoline, methysergide, sergolexole)JNJ-18038683KetanserinLY-215840Metitepine (methiothepin)RitanserinSB-258719SB-258741SB-269970SB-656104SB-656104ASB-691673SLV-313SLV-314SpiperoneSSR-181507Tetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin, mirtazapine)Tricyclic antidepressants (e.g., amitriptyline, clomipramine, imipramine)Typical antipsychotics (e.g., acetophenazine, chlorpromazine, chlorprothixene, fluphenazine, loxapine, pimozide)Vortioxetine
 |  |  Negative allosteric modulators: Oleamide
 |  |  | 
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 |  See also: Receptor/signaling modulatorsAdrenergicsDopaminergicsMelatonergicsMonoamine reuptake inhibitors and releasing agentsMonoamine metabolism modulatorsMonoamine neurotoxins
 | 
 |