SCH-79687 Names Preferred IUPAC name N -(3,5-Dichlorophenyl)-N ′-({4-[(1H -imidazol-4-yl)methyl]phenyl}methyl)urea
Identifiers ChEMBL ChemSpider UNII InChI=1S/C18H16Cl2N4O/c19-14-6-15(20)8-16(7-14)24-18(25)22-9-13-3-1-12(2-4-13)5-17-10-21-11-23-17/h1-4,6-8,10-11H,5,9H2,(H,21,23)(H2,22,24,25)
Y Key: CXNCQFJNXQAFND-UHFFFAOYSA-N
Y InChI=1/C18H16Cl2N4O/c19-14-6-15(20)8-16(7-14)24-18(25)22-9-13-3-1-12(2-4-13)5-17-10-21-11-23-17/h1-4,6-8,10-11H,5,9H2,(H,21,23)(H2,22,24,25)
Key: CXNCQFJNXQAFND-UHFFFAOYAC
Clc1cc(cc(Cl)c1)NC(=O)NCc2ccc(cc2)Cc3c[nH]cn3
Properties C18 H16 Cl2 N4 O Molar mass 375.251 g/mol Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
SCH-79687 is a histamine antagonist selective for the H3 subtype .[ 1]
References ^ McLeod RL, Rizzo CA, West RE Jr, Aslanian R, McCormick K, Bryant M, Hsieh Y, Korfmacher W, Mingo GG, Varty L, Williams SM, Shih NY, Egan RW, Hey JA. Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687). Journal of Pharmacology and Experimental Therapeutics . 2003 Jun;305(3):1037-44. PMID 12649305 doi=10.1124/jpet.103.049254
H1
Agonists Antagonists Others: Atypical antipsychotics (e.g., aripiprazole , asenapine , brexpiprazole , brilaroxazine , clozapine , iloperidone , olanzapine , paliperidone , quetiapine , risperidone , ziprasidone , zotepine ) Phenylpiperazine antidepressants (e.g., hydroxynefazodone , nefazodone , trazodone , triazoledione ) Tetracyclic antidepressants (e.g., amoxapine , loxapine , maprotiline , mianserin , mirtazapine , oxaprotiline ) Tricyclic antidepressants (e.g., amitriptyline , butriptyline , clomipramine , desipramine , dosulepin (dothiepin) , doxepin , imipramine , iprindole , lofepramine , nortriptyline , protriptyline , trimipramine ) Typical antipsychotics (e.g., chlorpromazine , flupenthixol , fluphenazine , loxapine , perphenazine , prochlorperazine , thioridazine , thiothixene ) Unknown/unsorted: Azanator Belarizine Elbanizine Flotrenizine GSK1004723 Napactadine Tagorizine Trelnarizine Trenizine
H2
H3
H4
See also Receptor/signaling modulators Monoamine metabolism modulators Monoamine reuptake inhibitors