VUF-8430

VUF-8430
Skeletal formula of VUF-8430
Skeletal formula of VUF-8430
Names
Preferred IUPAC name
2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester
Identifiers
3D model (JSmol)
Abbreviations VUF-8430
ChEMBL
ChemSpider
UNII
  • InChI=1S/C4H11N5S/c5-3(6)9-1-2-10-4(7)8/h1-2H2,(H3,7,8)(H4,5,6,9) checkY
    Key: GSYGTVNTZHFQQH-UHFFFAOYSA-N checkY
  • NC(=N)NCCSC(N)=N
Properties
C4H11N5S
Molar mass 161.23 g·mol−1
log P −1.367
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references

VUF-8430 is a histamine agonist[1] selective for the H4 subtype.[2]

References

  1. ^ Smith FM, Haskelberg H, Tracey DJ, Moalem-Taylor G (2007). "Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury". Neuroimmunomodulation. 14 (6): 317–25. doi:10.1159/000125048. PMID 18401194. S2CID 23020760.
  2. ^ Lim, HD; Smits, RA; Bakker, RA; Van Dam, CM; De Esch, IJ; Leurs, R (2006). "Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist". Journal of Medicinal Chemistry. 49 (23): 6650–1. doi:10.1021/jm060880d. PMID 17154494.


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